Osteoarthritis

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National Institute for Health and Care Excellence. Osteoarthritis in over 16s: diagnosis and management. Oct 2022 [internet publication].Full text

Bruyère O, Honvo G, Veronese N, et al. An updated algorithm recommendation for the management of knee osteoarthritis from the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO). Semin Arthritis Rheum. 2019 Dec;49(3):337-50.Full text  Abstract

1. Sharma L, Kapoor D, Issa S. Epidemiology of osteoarthritis: an update. Curr Opin Rheumatol. 2006;18:147-156. Abstract

2. Hunter DJ, Felson DT. Osteoarthritis. BMJ. 2006;332:639-642. Abstract

3. Altman R, Asch E, Bloch D, et al; Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Development of criteria for the classification and reporting of osteoarthritis: classification of osteoarthritis of the knee. Arthritis Rheum. 1986;29:1039-49. Abstract

4. Altman RD. Criteria for classification of clinical osteoarthritis. J Rheumatol Suppl. 1991 Feb;27:10-2. Abstract

5. Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957 Dec;16(4):494-502.Full text  Abstract

6. Schiphof D, Boers M, Bierma-Zeinstra SM. Differences in descriptions of Kellgren and Lawrence grades of knee osteoarthritis. Ann Rheum Dis. 2008 Jul;67(7):1034-6. Abstract

7. Kolasinski SL, Neogi T, Hochberg MC, et al. 2019 American College of Rheumatology/Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken). 2020 Feb;72(2):149-62.Full text  Abstract

8. Cisternas MG, Murphy L, Sacks JJ, et al. Alternative methods for defining osteoarthritis and the impact on estimating prevalence in a US population-based survey. Arthritis Care Res (Hoboken). 2016 May;68(5):574-80.Full text  Abstract

9. Zhang Y, Jordan JM. Epidemiology of osteoarthritis. Clin Geriatr Med. 2010 Aug;26(3):355-69.Full text  Abstract

10. Prieto-Alhambra D, Judge A, Javaid MK, et al. Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: influences of age, gender and osteoarthritis affecting other joints. Ann Rheum Dis. 2014 Sep;73(9):1659-64.Full text  Abstract

11. van der Oest MJW, Duraku LS, Andrinopoulou ER, et al. The prevalence of radiographic thumb base osteoarthritis: a meta-analysis. Osteoarthr Cartil. 2021 Jun;29(6):785-92.Full text  Abstract

12. Wilson MG, Michel CJ Jr, Ilstrup DM, et al. Idiopathic symptomatic osteoarthritis of the hip and knee: a population-based incidence study. Mayo Clin Proc. 1990; 65:1214-1221. Abstract

13. Oliveria SA, Felson DT, Reed JI, et al. Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization. Arthritis Rheum. 1995;38:1134-1141. Abstract

14. Moss AS, Murphy LB, Helmick CG, et al. Annual incidence rates of hip symptoms and three hip OA outcomes from a U.S. population-based cohort study: the Johnston County Osteoarthritis Project. Osteoarthr Cartil. 2016 Sep;24(9):1518-27.Full text  Abstract

15. Felson DT, Naimark A, Anderson J, et al. The prevalence of knee osteoarthritis in the elderly: the Framingham Osteoarthritis Study. Arthritis Rheum. 1987;30:914-918. Abstract

16. Felson DT, Zhang Y, Hannan MT, et al. The incidence and natural history of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum. 1995;38:1500-1505. Abstract

17. Kim C, Linsenmeyer KD, Vlad SC, et al. Prevalence of radiographic and symptomatic hip osteoarthritis in an urban United States community: the Framingham osteoarthritis study. Arthritis Rheumatol. 2014 Nov;66(11):3013-7.Full text  Abstract

18. Nevitt MC, Xu L, Zhang Y, et al. Very low prevalence of hip osteoarthritis among Chinese elderly in Beijing, China, compared with whites in the United States: the Beijing osteoarthritis study. Arthritis Rheum. 2002;46:1773-1779. Abstract

19. Zhang Y, Xu L, Nevitt MC, et al. Comparison of the prevalence of knee osteoarthritis between the elderly Chinese population in Beijing and whites in the United States: the Beijing Osteoarthritis Study. Arthritis Rheum. 2001;44:2065-2071. Abstract

20. Fan Z, Yan L, Liu H, et al. The prevalence of hip osteoarthritis: a systematic review and meta-analysis. Arthritis Res Ther. 2023 Mar 29;25(1):51.Full text  Abstract

21. Glyn-Jones S, Palmer AJ, Agricola R, et al. Osteoarthritis. Lancet. 2015 Jul 25;386(9991):376-87. Abstract

22. Reyes C, Leyland KM, Peat G, et al. Association between overweight and obesity and risk of clinically diagnosed knee, hip, and hand osteoarthritis: a population-based cohort study. Arthritis Rheumatol. 2016 Aug;68(8):1869-75.Full text  Abstract

23. Silverwood V, Blagojevic-Bucknall M, Jinks C, et al. Current evidence on risk factors for knee osteoarthritis in older adults: a systematic review and meta-analysis. Osteoarthritis Cartilage. 2015 Apr;23(4):507-15.Full text  Abstract

24. Spector TD, Cicuttini F, Baker J, et al. Genetic influences on osteoarthritis in women: a twin study. BMJ. 1996;312:940-3. Abstract

25. Valdes AM, Spector TD. Genetic epidemiology of hip and knee osteoarthritis. Nat Rev Rheumatol. 2011 Jan;7(1):23-32. Abstract

26. Tanamas S, Hanna FS, Cicuttini FM, et al. Does knee malalignment increase the risk of development and progression of knee osteoarthritis? A systematic review. Arthritis Rheum. 2009 Apr 15;61(4):459-67.Full text  Abstract

27. Brouwer GM, van Tol AW, Bergink AP, et al. Association between valgus and varus alignment and the development and progression of radiographic osteoarthritis of the knee. Arthritis Rheum. 2007 Apr;56(4):1204-11.Full text  Abstract

28. van Buuren MMA, Arden NK, Bierma-Zeinstra SMA, et al. Statistical shape modeling of the hip and the association with hip osteoarthritis: a systematic review. Osteoarthr Cartil. 2021 May;29(5):607-18.Full text  Abstract

29. Cinque ME, Dornan GJ, Chahla J, et al. High rates of osteoarthritis develop after anterior cruciate ligament surgery: an analysis of 4108 patients. Am J Sports Med. 2018 Jul;46(8):2011-19. Abstract

30. Chen T, Wang S, Li Y, et al. Radiographic osteoarthritis prevalence over ten years after anterior cruciate ligament reconstruction. Int J Sports Med. 2019 Oct;40(11):683-95.Full text  Abstract

31. Cerejo R, Dunlop DD, Cahue S, et al. The influence of alignment on risk of knee osteoarthritis progression according to baseline stage of disease. Arthritis Rheum. 2002 Oct;46(10):2632-6.Full text  Abstract

32. Chang A, Hayes K, Dunlop D, et al. Thrust during ambulation and progression of knee osteoarthritis. Arthritis Rheum. 2004;50:3897-903. Abstract

33. Felson DT. Clinical practice. Osteoarthritis of the knee. N Engl J Med. 2006;354:841-8. Abstract

34. Heinemeier KM, Schjerling P, Heinemeier J, et al. Radiocarbon dating reveals minimal collagen turnover in both healthy and osteoarthritic human cartilage. Sci Transl Med. 2016 Jul 6;8(346):346ra90. Abstract

35. Sohn DH, Sokolove J, Sharpe O, et al. Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4. Arthritis Res Ther. 2012 Jan 8;14(1):R7.Full text  Abstract

36. Li T, Chubinskaya S, Esposito A, et al. TGF-β type 2 receptor-mediated modulation of the IL-36 family can be therapeutically targeted in osteoarthritis. Sci Transl Med. 2019 May 8;11(491):eaan2585.Full text  Abstract

37. Budhiparama NC, Lumban-Gaol I, Sudoyo H, et al. Interleukin-1 genetic polymorphisms in knee osteoarthritis: What do we know? A meta-analysis and systematic review. J Orthop Surg (Hong Kong). 2022 Jan-Apr;30(1):23094990221076652.Full text  Abstract

38. Lee YH, Song GG. Association between IL-17 gene polymorphisms and circulating IL-17 levels in osteoarthritis: a meta-analysis. Z Rheumatol. 2020 Jun;79(5):482-90. Abstract

39. Gao S, Mao C, Cheng J, et al. Association of IL-17A-197G/A and IL-17F-7488T/C polymorphisms and osteoarthritis susceptibility: a meta-analysis. Int J Rheum Dis. 2020 Jan;23(1):37-46. Abstract

40. Tu M, Yao Y, Qiao FH, et al. The pathogenic role of connective tissue growth factor in osteoarthritis. Biosci Rep. 2019 Jul 31;39(7):BSR20191374.Full text  Abstract

41. Troeberg L, Nagase H. Proteases involved in cartilage matrix degradation in osteoarthritis. Biochim Biophys Acta. 2012 Jan;1824(1):133-45.Full text  Abstract

42. Loeser RF, Collins JA, Diekman BO. Ageing and the pathogenesis of osteoarthritis. Nat Rev Rheumatol. 2016 Jul;12(7):412-20.Full text  Abstract

43. Coryell PR, Diekman BO, Loeser RF. Mechanisms and therapeutic implications of cellular senescence in osteoarthritis. Nat Rev Rheumatol. 2021 Jan;17(1):47-57. Abstract

44. Van Pevenage PM, Birchmier JT, June RK. Utilizing metabolomics to identify potential biomarkers and perturbed metabolic pathways in osteoarthritis: a systematic review. Semin Arthritis Rheum. 2023 Apr;59:152163.Full text  Abstract

45. Zheng L, Zhang Z, Sheng P, et al. The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis. Ageing Res Rev. 2021 Mar;66:101249.Full text  Abstract

46. Lee YH, Song GG. Circulating leptin level in osteoarthritis and associations between leptin receptor polymorphisms and disease susceptibility: a meta-analysis. Int J Rheum Dis. 2023 Jul;26(7):1305-13. Abstract

47. Chen B, Ning K, Sun ML, et al. Regulation and therapy, the role of JAK2/STAT3 signaling pathway in OA: a systematic review. Cell Commun Signal. 2023 Apr 3;21(1):67.Full text  Abstract

48. Sharma L, Song J, Felson DT, et al. The role of knee alignment in disease progression and functional decline in knee osteoarthritis. JAMA. 2001;286:188-195. Abstract

49. Hart DJ, Doyle DV, Spector TD. Incidence and risk factors for radiographic knee osteoarthritis in middle-aged women: the Chingford Study. Arthritis Rheum. 1999;42:17-24. Abstract

50. Kallman DA, Wigley FM, Scott WW Jr, et al. The longitudinal course of hand osteoarthritis in a male population. Arthritis Rheum. 1990;33:1323-1331. Abstract

51. Felson DT, Zhang Y, Hannan MT, et al. Risk factors for incident radiographic knee osteoarthritis in the elderly: the Framingham Study. Arthritis Rheum. 1997 Apr;40(4):728-33.Full text  Abstract

52. Felson DT, Anderson JJ, Naimark A, et al. Obesity and knee osteoarthritis. The Framingham Study. Ann Intern Med. 1988;109:18-24. Abstract

53. Francomano CA, Liberfarb RM, Hirose T, et al. The Stickler syndrome: evidence for close linkage to the structural gene for type II collagen. Genomics. 1987;1:293-6. Abstract

54. Kannu P, Bateman JF, Randle S, et al. Premature arthritis is a distinct type II collagen phenotype. Arthritis Rheum. 2010 May;62(5):1421-30.Full text  Abstract

55. Kannu P, Bateman J, Savarirayan R. Clinical phenotypes associated with type II collagen mutations. J Paediatr Child Health. 2012 Feb;48(2):E38-43. Abstract

56. Zhang W, Doherty M, Leeb BF, et al. EULAR evidence-based recommendations for the diagnosis of hand osteoarthritis: report of a task force of ESCISIT. Ann Rheum Dis. 2009 Jan;68(1):8-17.Full text  Abstract

57. Casartelli NC, Maffiuletti NA, Valenzuela PL, et al. Is hip morphology a risk factor for developing hip osteoarthritis? A systematic review with meta-analysis. Osteoarthr Cartil. 2021 Sep;29(9):1252-64.Full text  Abstract

58. Cooper C. Occupational activity and the risk of osteoarthritis. J Rheumatol Suppl. 1995;22(Suppl 43):10-12. Abstract

59. Maetzel A, Makela M, Hawker G, et al. Osteoarthritis of the hip and knee and mechanical occupational exposure - a systematic overview of the evidence. J Rheumatol. 1997;24:1599-1607. Abstract

60. Sapolsky HM. Prospective payment in perspective. J Health Polit Policy Law. 1986;11(4):633-45. Abstract

61. Croft P, Cooper C, Wickham C, et al. Osteoarthritis of the hip and occupational activity. Scand J Work Env Health. 1992;18:59-63. Abstract

62. Driban JB, Hootman JM, Sitler MR, et al. Is participation in certain sports associated with knee osteoarthritis? A systematic review. J Athl Train. 2017 Jun 2;52(6):497-506.Full text  Abstract

63. Whittaker JL, Losciale JM, Juhl CB, et al. Risk factors for knee osteoarthritis after traumatic knee injury: a systematic review and meta-analysis of randomised controlled trials and cohort studies for the OPTIKNEE Consensus. Br J Sports Med. 2022 Dec;56(24):1406-21.Full text  Abstract

64. Webster KE, Hewett TE. Anterior cruciate ligament injury and knee osteoarthritis: an umbrella systematic review and meta-analysis. Clin J Sport Med. 2022 Mar 1;32(2):145-52. Abstract

65. Hannan MT, Anderson JJ, Zhang Y, et al. Bone mineral density and knee osteoarthritis in elderly men and women. The Framingham Study. Arthritis Rheum. 1993;36:1671-1680. Abstract

66. Bergink AP, Rivadeneira F, Bierma-Zeinstra SM, et al. Are bone mineral density and fractures related to the incidence and progression of radiographic osteoarthritis of the knee, hip, and hand in elderly men and women? The Rotterdam study. Arthritis Rheumatol. 2019 Mar;71(3):361-9. Abstract

67. Hartley A, Hardcastle SA, Frysz M, et al. Increased development of radiographic hip osteoarthritis in individuals with high bone mass: a prospective cohort study. Arthritis Res Ther. 2021 Jan 6;23(1):4.Full text  Abstract

68. Whittaker JL, Culvenor AG, Juhl CB, et al. OPTIKNEE 2022: consensus recommendations to optimise knee health after traumatic knee injury to prevent osteoarthritis. Br J Sports Med. 2022 Dec;56(24):1393-405.Full text  Abstract

69. Brandt KD, Mazzuca SA, Katz BP, et al. Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial. Arthritis Rheum. 2005;52:2015-2025. Abstract

70. da Costa BR, Nüesch E, Reichenbach S, et al. Doxycycline for osteoarthritis of the knee or hip. Cochrane Database Syst Rev. 2012 Nov 14;(11):CD007323. Abstract

71. Lee YH, Woo JH, Choi SJ, et al. Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression: a meta-analysis. Rheumatol Int. 2010 Jan;30(3):357-63. Abstract

72. Kouki I, Tuffet S, Crema MD, et al. Metacarpophalangeal joint impairment in hand osteoarthritis and its association with mechanical factors: results from the digital cohort osteoarthritis design hand osteoarthritis cohort. Arthritis Care Res (Hoboken). 2022 Oct;74(10):1696-703. Abstract

73. National Institute for Health and Care Excellence. Osteoarthritis in over 16s: diagnosis and management. Oct 2022 [internet publication].Full text

74. van Tunen JAC, Dell'Isola A, Juhl C, et al. Association of malalignment, muscular dysfunction, proprioception, laxity and abnormal joint loading with tibiofemoral knee osteoarthritis - a systematic review and meta-analysis. BMC Musculoskelet Disord. 2018 Jul 28;19(1):273.Full text  Abstract

75. Altman R, Alarcon G, Appelrouth D. The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hand. Arthritis Rheum. 1990;33:1601-1610. Abstract

76. Peat G, Duncan RC, Wood LR, et al. Clinical features of symptomatic patellofemoral joint osteoarthritis. Arthritis Res Ther. 2012 Mar 14;14(2):R63.Full text  Abstract

77. Sakellariou G, Conaghan PG, Zhang W, et al. EULAR recommendations for the use of imaging in the clinical management of peripheral joint osteoarthritis. Ann Rheum Dis. 2017 Sep;76(9):1484-94.Full text  Abstract

78. Altman R, Alarcon G, Appelrouth D. The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip. Arthritis Rheum. 1991;34:505-514. Abstract

79. Fox MG, Chang EY, Amini B, et al; Expert Panel on Musculoskeletal Imaging. ACR appropriateness criteria®: chronic knee pain. J Am Coll Radiol. 2018 Nov;15(11s):S302-12.Full text  Abstract

80. Hayashi D, Roemer FW, Guermazi A. Imaging for osteoarthritis. Ann Phys Rehabil Med. 2016 Jun;59(3):161-9.Full text  Abstract

81. American Orthopaedic Foot & Ankle Society. Five things physicians and patients should question. Choosing Wisely, an initiative of the ABIM Foundation. 2021 [internet publication].Full text

82. Wesseling J, Bierma-Zeinstra SM, Kloppenburg M, et al. Worsening of pain and function over 5 years in individuals with 'early' OA is related to structural damage: data from the Osteoarthritis Initiative and CHECK (Cohort Hip & Cohort Knee) study. Ann Rheum Dis. 2015;74:347-353. Abstract

83. Yusuf E, Kortekaas MC, Watt I, et al. Do knee abnormalities visualised on MRI explain knee pain in knee osteoarthritis? A systematic review. Ann Rheum Dis. 2011 Jan;70(1):60-7. Abstract

84. Foong YC, Khan HI, Blizzard L, et al. The clinical significance, natural history and predictors of bone marrow lesion change over eight years. Arthritis Res Ther. 2014 Jul 14;16(4):R149.Full text  Abstract

85. Felson DT, McLaughlin S, Goggins J, et al. Bone marrow edema and its relation to progression to knee osteoarthritis. Ann Intern Med. 2003;139:330-336. Abstract

86. Imhof H, Breitenseher M, Trattnig S, et al. Imaging of avascular necrosis of bone. Eur Radiol. 1997;7:180-186. Abstract

87. American College of Radiology; Subhas N, Wu F, et al. ACR Appropriateness Criteria® chronic extremity joint pain-suspected inflammatory arthritis, crystalline arthritis, or erosive osteoarthritis: 2022 Update. J Am Coll Radiol. 2023 May;20(5s):S20-S32.Full text  Abstract

88. American College of Radiology. ACR appropriateness criteria: chronic hip pain. 2022 [internet publication].Full text

89. Zhang W, Robertson J, Jones AC, et al. The placebo effect and its determinants in osteoarthritis: meta-analysis of randomised controlled trials. Ann Rheum Dis. 2008;67:1716-23. Abstract

90. Previtali D, Merli G, Di Laura Frattura G, et al. The long-lasting effects of "placebo injections" in knee osteoarthritis: a meta-analysis. Cartilage. 2021 Dec;13(suppl 1):185S-96S.Full text  Abstract

91. Bannuru RR, McAlindon TE, Sullivan MC, et al. Effectiveness and implications of alternative placebo treatments: a systematic review and network meta-analysis of osteoarthritis trials. Ann Intern Med. 2015;163:365-372. Abstract

92. Bricca A, Juhl CB, Steultjens M, et al. Impact of exercise on articular cartilage in people at risk of, or with established, knee osteoarthritis: a systematic review of randomised controlled trials. Br J Sports Med. 2019 Aug;53(15):940-7.Full text  Abstract

93. Gohir SA, Eek F, Kelly A, et al. Effectiveness of internet-based exercises aimed at treating knee osteoarthritis: the iBEAT-OA randomized clinical trial. JAMA Netw Open. 2021 Feb 1;4(2):e210012.Full text  Abstract

94. Dong R, Wu Y, Xu S, et al. Is aquatic exercise more effective than land-based exercise for knee osteoarthritis? Medicine (Baltimore). 2018 Dec;97(52):e13823.Full text  Abstract

95. Goff AJ, De Oliveira Silva D, Merolli M, et al. Patient education improves pain and function in people with knee osteoarthritis with better effects when combined with exercise therapy: a systematic review. J Physiother. 2021 Jul;67(3):177-89.Full text  Abstract

96. Sasaki R, Honda Y, Oga S, et al. Effect of exercise and/or educational interventions on physical activity and pain in patients with hip/knee osteoarthritis: a systematic review with meta-analysis. PLoS One. 2022;17(11):e0275591.Full text  Abstract

97. Hu L, Wang Y, Liu X, et al. Tai Chi exercise can ameliorate physical and mental health of patients with knee osteoarthritis: systematic review and meta-analysis. Clin Rehabil. 2021 Jan;35(1):64-79.Full text  Abstract

98. Pitsillides A, Stasinopoulos D, Giannakou K. The effects of cognitive behavioural therapy delivered by physical therapists in knee osteoarthritis pain: a systematic review and meta-analysis of randomized controlled trials. J Bodyw Mov Ther. 2021 Jan;25:157-64. Abstract

99. Brosseau L, Wells GA, Pugh AG, et al. Ottawa Panel evidence-based clinical practice guidelines for therapeutic exercise in the management of hip osteoarthritis. Clin Rehabil. 2016 Oct;30(10):935-46. Abstract

100. Jansen MJ, Viechtbauer W, Lenssen AF, et al. Strength training alone, exercise therapy alone, and exercise therapy with passive manual mobilisation each reduce pain and disability in people with knee osteoarthritis: a systematic review. J Physiother. 2011;57:11-20. Abstract

101. Dziedzic K, Nicholls E, Hill S, et al. Self-management approaches for osteoarthritis in the hand: a 2x2 factorial randomised trial. Ann Rheum Dis. 2015;74:108-118.Full text  Abstract

102. Anwer S, Alghadir A, Zafar H, et al. Effects of orthopaedic manual therapy in knee osteoarthritis: a systematic review and meta-analysis. Physiotherapy. 2018 Sep;104(3):264-76. Abstract

103. Fransen M, McConnell S, Harmer AR, et al. Exercise for osteoarthritis of the knee. Cochrane Database Syst Rev. 2015;(1):CD004376.Full text  Abstract

104. Fransen M, McConnell S, Hernandez-Molina G, et al. Exercise for osteoarthritis of the hip. Cochrane Database Syst Rev. 2014;(4):CD007912.Full text  Abstract

105. Bennell KL, Egerton T, Martin J, et al. Effect of physical therapy on pain and function in patients with hip osteoarthritis: a randomized clinical trial. JAMA. 2014;311:1987-1997.Full text  Abstract

106. Fransen M, McConnell S, Hernandez-Molina G, et al. Does land-based exercise reduce pain and disability associated with hip osteoarthritis? A meta-analysis of randomized controlled trials. Osteoarthritis Cartilage. 2010;18:613-620. Abstract

107. Teirlinck CH, Verhagen AP, Reijneveld EAE, et al. Responders to exercise therapy in patients with osteoarthritis of the hip: a systematic review and meta-analysis. Int J Environ Res Public Health. 2020 Oct 10;17(20):7380.Full text  Abstract

108. Thomas DT, R S, Prabhakar AJ, et al. Hip abductor strengthening in patients diagnosed with knee osteoarthritis - a systematic review and meta-analysis. BMC Musculoskelet Disord. 2022 Jun 29;23(1):622.Full text  Abstract

109. Messier SP, Mihalko SL, Legault C, et al. Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial. JAMA. 2013;310:1263-1273.Full text  Abstract

110. Christensen R, Henriksen M, Leeds AR, et al. Effect of weight maintenance on symptoms of knee osteoarthritis in obese patients: a twelve-month randomized controlled trial. Arthritis Care Res (Hoboken). 2015;67:640-650.Full text  Abstract

111. Hislop AC, Collins NJ, Tucker K, et al. Does adding hip exercises to quadriceps exercises result in superior outcomes in pain, function and quality of life for people with knee osteoarthritis? A systematic review and meta-analysis. Br J Sports Med. 2020 Mar;54(5):263-71.Full text  Abstract

112. Raghava Neelapala YV, Bhagat M, Shah P. Hip muscle strengthening for knee osteoarthritis: a systematic review of literature. J Geriatr Phys Ther. 2020 Apr/Jun;43(2):89-98.Full text  Abstract

113. Jurado-Castro JM, Muñoz-López M, Ledesma AS, et al. Effectiveness of exercise in patients with overweight or obesity suffering from knee osteoarthritis: a systematic review and meta-analysis. Int J Environ Res Public Health. 2022 Aug 24;19(17):10510.Full text  Abstract

114. Hall M, Castelein B, Wittoek R, et al. Diet-induced weight loss alone or combined with exercise in overweight or obese people with knee osteoarthritis: A systematic review and meta-analysis. Semin Arthritis Rheum. 2019 Apr;48(5):765-77. Abstract

115. Chu SF, Liou TH, Chen HC, et al. Relative efficacy of weight management, exercise, and combined treatment for muscle mass and physical sarcopenia indices in adults with overweight or obesity and osteoarthritis: a network meta-analysis of randomized controlled trials. Nutrients. 2021 Jun 10;13(6):1992.Full text  Abstract

116. Huang XM, Yuan FZ, Chen YR, et al. Physical therapy and orthopaedic equipment-induced reduction in the biomechanical risk factors related to knee osteoarthritis: a systematic review and Bayesian network meta-analysis of randomised controlled trials. BMJ Open. 2022 Feb 9;12(2):e051608.Full text  Abstract

117. Parkes MJ, Maricar N, Lunt M, et al. Lateral wedge insoles as a conservative treatment for pain in patients with medial knee osteoarthritis: a meta-analysis. JAMA. 2013;310:722-730.Full text  Abstract

118. Yu L, Wang Y, Yang J, et al. Effects of orthopedic insoles on patients with knee osteoarthritis: a meta-analysis and systematic review. J Rehabil Med. 2021 May 18;53(5):jrm00191.Full text  Abstract

119. Jindasakchai P, Angthong C, Panyarachun P, et al. Therapeutic significance of insoles in patients with knee osteoarthritis. Eur Rev Med Pharmacol Sci. 2023 Jun;27(11):5023-30.Full text  Abstract

120. Alfatafta H, Onchonga D, Alfatafta M, et al. Effect of using knee valgus brace on pain and activity level over different time intervals among patients with medial knee OA: systematic review. BMC Musculoskelet Disord. 2021 Aug 12;22(1):687.Full text  Abstract

121. Duivenvoorden T, Brouwer RW, van Raaij TM, et al. Braces and orthoses for treating osteoarthritis of the knee. Cochrane Database Syst Rev. 2015;(3):CD004020.Full text  Abstract

122. Moyer RF, Birmingham TB, Bryant DM, et al. Valgus bracing for knee osteoarthritis: a meta-analysis of randomized trials. Arthritis Care Res (Hoboken). 2015;67:493-501. Abstract

123. Gohal C, Shanmugaraj A, Tate P, et al. Effectiveness of valgus offloading knee braces in the treatment of medial compartment knee osteoarthritis: a systematic review. Sports Health. 2018 Nov/Dec;10(6):500-14. Abstract

124. Fan Y, Li Z, Zhang H, et al. Valgus knee bracing may have no long-term effect on pain improvement and functional activity in patients with knee osteoarthritis: a meta-analysis of randomized trials. J Orthop Surg Res. 2020 Sep 1;15(1):373.Full text  Abstract

125. Khosravi M, Babaee T, Daryabor A, et al. Effect of knee braces and insoles on clinical outcomes of individuals with medial knee osteoarthritis: a systematic review and meta-analysis. Assist Technol. 2022 Sep 3;34(5):501-17. Abstract

126. Hinman RS, Wrigley TV, Metcalf BR, et al. Unloading shoes for self-management of knee osteoarthritis: a randomized trial. Ann Intern Med. 2016;165:381-89. Abstract

127. Callaghan MJ, Parkes MJ, Hutchinson CE, et al. A randomised trial of a brace for patellofemoral osteoarthritis targeting knee pain and bone marrow lesions. Ann Rheum Dis. 2015;74:1164-70.Full text  Abstract

128. Callaghan MJ, Palmer E, O'Neill T. Management of patellofemoral joint osteoarthritis using biomechanical device therapy: a systematic review with meta-analysis. Syst Rev. 2021 Jun 9;10(1):173.Full text  Abstract

129. Buhler M, Chapple CM, Stebbings S, et al. Effectiveness of splinting for pain and function in people with thumb carpometacarpal osteoarthritis: a systematic review with meta-analysis. Osteoarthritis Cartilage. 2019 Apr;27(4):547-59.Full text  Abstract

130. Honvo G, Reginster JY, Rabenda V, et al. Safety of symptomatic slow-acting drugs for osteoarthritis: outcomes of a systematic review and meta-analysis. Drugs Aging. 2019 Apr;36(suppl 1):65-99.Full text  Abstract

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