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Eosinophilic esophagitis

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  • 概述
  • 理论
  • 诊断
  • 治疗
  • 随访
  • 资源
最后审阅： 28 Feb 2026
最后更新： 16 Dec 2025

小结

定义

病史和体格检查

关键诊断因素

  • dysphagia
  • food avoidance and modification behaviors
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其他诊断因素

  • heartburn
  • chest discomfort
  • nausea/vomiting
  • regurgitation
  • abdominal pain
  • failure to thrive
  • irritability
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危险因素

  • family history of eosinophilic esophagitis (EoE)
  • male sex
  • atopic disease
  • children and younger adults
  • white ancestry
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诊断性检查

首要检查

  • esophagogastroduodenoscopy
  • esophageal biopsy
  • CBC with differential
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需考虑的检查

  • barium swallow (esophagram)
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新兴检查

  • unsedated transnasal endoscopy
  • esophageal string test
  • cytosponge
  • esophageal physiological testing
  • eosinophilic esophagitis (EoE) diagnostic panel

治疗流程

急症处理

at initial diagnosis

持续性治疗

response to initial therapy

nonresponse or relapse

撰稿人

作者

Jenny Epstein, MB ChB MRCPCH PhD

Consultant Paediatric Gastroenterologist

Chelsea and Westminster Hospital

London

UK

利益声明

JE is a member of the advisory board for Dr Falk Pharma, manufacturer of Jorveza, a new formulation of budesonide licensed for adults with eosinophilic esophagitis (EoE), and Nurtricia for infant functional bowel disorders. She has received honoraria from Dr Falk Pharma to speak on EoE and has been sponsored by Dr Falk Pharma, Abbvie and Nutricia to attend national and international meetings. JE is a member of BSPGHAN IBD working group, medical advisor to CICRA and Coeliac UK, member of CCUK IBD working group, member of BSG EoE Guideline development group, member of NICE Guideline update committee for Crohn disease and ulcerative colitis, member of NICE Diagnostics, and sits on the NICE advisory committee for personalized treatment in Crohn disease.

鸣谢

We would like to acknowledge our Gastroenterology expert panel member, Dr Brooks D.Cash, for his contribution to this topic. Dr Jenny Epstein wishes to gratefully acknowledge Dr Evan S. Dellon, the previous contributor to this topic.

利益声明

BDC declares that he has no competing interests. ESD is an author of a number of references cited in this topic.

同行评议者

David Katzka, MD

Professor of Medicine

Mayo Clinic

Rochester

MN

利益声明

DK has served on advisory boards (Adare, Receptos) and received research funding (Covidien).

Alexandra Papadopoulou, MD

Honorary Professor

Chief of the Division of Gastroenterology and Hepatology

First Department of Pediatrics

University of Athens

Agia Sofia Children’s Hospital

Athens

Greece

Disclosures

AP has received speaker’s honorariums from Nestle and Nutricia; research grants from Biogaia/Nutricia/Abbvie; consultant’s fee from Receptos.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

References

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Key articles

Dhar A, Haboubi HN, Attwood SE, et al. British Society of Gastroenterology (BSG) and British Society of Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN) joint consensus guidelines on the diagnosis and management of eosinophilic oesophagitis in children and adults. Gut. 2022 Aug;71(8):1459-87.Full text  Abstract

Dellon ES, Muir AB, Katzka DA, et al. ACG clinical guideline: diagnosis and management of eosinophilic esophagitis. Am J Gastroenterol. 2025 Jan 1;120(1):31-59.Full text  Abstract

Amil-Dias J, Oliva S, Papadopoulou A, et al. Diagnosis and management of eosinophilic esophagitis in children: an update from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN). J Pediatr Gastroenterol Nutr. 2024 Aug;79(2):394-437.Full text  Abstract

Hirano I, Chan ES, Rank MA, et al. AGA institute and the joint task force on allergy-immunology practice parameters clinical guidelines for the management of eosinophilic esophagitis. Ann Allergy Asthma Immunol. 2020 May;124(5):416-23.Full text  Abstract

Reference articles

A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
  • Eosinophilic esophagitis images

  • Differentials

    • Gastroesophageal reflux disease (GERD)
    • Eosinophilic gastroenteritis
    • Achalasia
    More Differentials

  • Guidelines

    • Diagnosis and management of eosinophilic esophagitis
    • Diagnosis and management of eosinophilic esophagitis in children
    More Guidelines
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