The World Health Organization estimates that globally there are 257 million people living with Hepatitis B virus (HBV) infection (defined as being hepatitis B surface antigen-positive).[9] Other sources estimate that approximately 350 million people worldwide suffer from chronic HBV infection.[10] Globally, there were 887,000 HBV-related deaths in 2015, mostly from complications such as cirrhosis and hepatocellular carcinoma.[9] There are almost 2 million new infections in children <5 years of age globally each year, with most cases occurring as a result of mother-to-child transmission.[11]

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