Infectious mononucleosis


Key articles

Vetsika EK, Callan M. Infectious mononucleosis and Epstein-Barr virus. Expert Rev Mol Med. 2004 Nov 5;6(23):1-16. Abstract

Katz BZ. Update on chronic fatigue syndrome and Epstein-Barr virus. Pediatr Ann. 2002 Nov;31(11):741-4. Abstract

Ganzel TM, Goldman JL, Padhya TA. Otolaryngologic clinical patterns in pediatric infectious mononucleosis. Am J Otolaryngol. 1996 Nov-Dec;17(6):397-400. Abstract

De Paor M, O'Brien K, Fahey T, et al. Antiviral agents for infectious mononucleosis (glandular fever). Cochrane Database Syst Rev. 2016 Dec 8;(12):CD011487.Full text  Abstract

Reference articles

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28. Vetsika EK, Callan M. Infectious mononucleosis and Epstein-Barr virus. Expert Rev Mol Med. 2004 Nov 5;6(23):1-16. Abstract

29. Abbott RJ, Pachnio A, Pedroza-Pacheco I, et al. Asymptomatic primary infection with Epstein-Barr virus: observations on young adult cases. J Virol. 2017 Oct 13;91(21).Full text  Abstract

30. Cohen JI. Vaccine development for Epstein-Barr virus. Adv Exp Med Biol. 2018;1045:477-93.Full text  Abstract

31. Winter JR, Jackson C, Lewis JE, et al. Predictors of Epstein-Barr virus serostatus and implications for vaccine policy: A systematic review of the literature. J Glob Health. 2020 Jun;10(1):010404.Full text  Abstract

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33. Fugl A, Andersen CL. Epstein-Barr virus and its association with disease - a review of relevance to general practice. BMC Fam Pract. 2019 May 14;20(1):62.Full text  Abstract

34. Auwaerter PG. Recent advances in the understanding of infectious mononucleosis: are prospects improved for treatment or control? Expert Rev Anti Infect Ther. 2006 Dec;4(6):1039-49. Abstract

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37. Ebell MH. Epstein-Barr virus infectious mononucleosis. Am Fam Physician. 2004 Oct 1;70(7):1279-87.Full text  Abstract

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39. Bell AT, Fortune B, Sheeler R. Clinical inquiries. What test is the best for diagnosing infectious mononucleosis? J Fam Pract. 2006 Sep;55(9):799-802. Abstract

40. Hess RD. Routine Epstein-Barr virus diagnostics from the laboratory perspective: still challenging after 35 years. J Clin Microbiol. 2004 Aug;42(8):3381-7.Full text  Abstract

41. Smellie WSA, Forth J, Smart SRS, et al. Best practice in primary care pathology: review 7. J Clin Pathol. 2007 May;60(5):458-65.Full text  Abstract

42. Vouloumanou EK, Rafailidis PI, Falagas ME. Current diagnosis and management of infectious mononucleosis. Curr Opin Hematol. 2012 Jan;19(1):14-20. Abstract

43. Niller HH, Bauer G. Epstein-Barr virus: clinical diagnostics. Methods Mol Biol. 2017;1532:33-55.Full text  Abstract

44. Mergoum AM. Amoxicillin rash in infectious mononucleosis. N Engl J Med. 2021 Sep 9;385(11):1033.Full text  Abstract

45. Schechter S, Lamps L. Epstein-Barr virus hepatitis: a review of clinicopathologic features and differential diagnosis. Arch Pathol Lab Med. 2018 Oct;142(10):1191-5.Full text  Abstract

46. Kofteridis DP, Koulentaki M, Valachis A, et al. Epstein Barr virus hepatitis. Eur J Intern Med. 2011 Feb;22(1):73-6.Full text  Abstract

47. Katz BZ. Update on chronic fatigue syndrome and Epstein-Barr virus. Pediatr Ann. 2002 Nov;31(11):741-4. Abstract

48. Miller JM, Binnicker MJ, Campbell S, et al. A guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2018 update by the Infectious Diseases Society of America and the American Society for Microbiology. Clin Infect Dis. 2018 Aug 31;67(6):e1-94.Full text  Abstract

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50. Bauer CC, Aberle SW, Popow-Kraupp T, et al. Serum Epstein-Barr virus DNA load in primary Epstein-Barr virus infection. J Med Virol. 2005 Jan;75(1):54-8. Abstract

51. Shi T, Huang L, Luo L, et al. Diagnostic value of serological and molecular biological tests for infectious mononucleosis by EBV in different age stages and course of the disease. J Med Virol. 2021 Jun;93(6):3824-34.Full text  Abstract

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54. Ganzel TM, Goldman JL, Padhya TA. Otolaryngologic clinical patterns in pediatric infectious mononucleosis. Am J Otolaryngol. 1996 Nov-Dec;17(6):397-400. Abstract

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56. Walter RB, Hong TC, Bachli EB. Life-threatening thrombocytopenia associated with acute Epstein-Barr virus infection in an older adult. Ann Hematol. 2002 Nov;81(11):672-5. Abstract

57. Roy M, Bailey B, Amre DK, et al. Dexamethasone for the treatment of sore throat in children with suspected infectious mononucleosis: a randomized, double-blind, placebo-controlled, clinical trial. Arch Pediatr Adolesc Med. 2004 Mar;158(3):250-4.Full text  Abstract

58. Rezk E, Nofal YH, Hamzeh A, et al. Steroids for symptom control in infectious mononucleosis. Cochrane Database Syst Rev. 2015 Nov 8;(11):CD004402.Full text  Abstract

59. Webster J, Osborne S, Rickard CM, et al. Clinically-indicated replacement versus routine replacement of peripheral venous catheters. Cochrane Database Syst Rev. 2019 Jan 23;(1):CD007798.Full text  Abstract

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62. De Paor M, O'Brien K, Fahey T, et al. Antiviral agents for infectious mononucleosis (glandular fever). Cochrane Database Syst Rev. 2016 Dec 8;(12):CD011487.Full text  Abstract

63. Torre D, Tambini R. Acyclovir for treatment of infectious mononucleosis: a meta-analysis. Scand J Infect Dis. 1999;31(6):543-7. Abstract

64. Rafailidis PIM. Antiviral treatment for severe EBV infections in apparently immunocompetent patients. J Clin Virol. 2010 Nov;49(3):151-7. Abstract

65. Ma C, Wong KC, Wong BCK, et al. Cytokine responses in a severe case of glandular fever treated successfully with foscarnet combined with prednisolone and intravenous immunoglobulin. J Med Virol. 2009 Jan;81(1):99-105. Abstract

66. Balfour HH, Hokanson KM, Schacherer RM, et al. A virologic pilot study of valacyclovir in infectious mononucleosis. J Clin Virol. 2007 May;39(1):16-21. Abstract

67. Adams LA, Deboer B, Jeffrey G, et al. Gancyclovir and the treatment of Epstein-Barr virus hepatitis. J Gastroenterol Hepatol. 2006 Nov;21(11):1758-60. Abstract

68. Yager JE, Magaret AS,3, Kuntz SR, et al. Valganciclovir for the suppression of Epstein-Barr virus replication. J Infect Dis. 2017 Jul 15;216(2):198-202.Full text  Abstract

69. La Mantia I, Varricchio A, Andaloro C, et al. Pidotimod in children with infectious mononucleosis: a preliminary randomized controlled study. J Biol Regul Homeost Agents. 2020 Jul-Aug;34(4):1597-9.Full text  Abstract

70. Zhang L, Goudth J, Christmas D, et al. Microbial infections in eight genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). J Clin Pathol. 2010 Feb;63(2):156-64.Full text  Abstract

71. Lerner AM, Beqaj SH, Deeter RG, et al. Valacyclovir treatment in Epstein-Barr virus subset chronic fatigue syndrome: thirty-six months follow-up. In Vivo. 2007 Sep-Oct;21(5):707-13.Full text  Abstract

72. Kogelnik AM, Loomis K, Hoegh-Peterson M, et al. Use of valganciclovir with elevated antibody titers against Human herpesvirus-6 (HHV-6) and Epstein-Barr virus (EBV) who were experiencing central nervous system dysfunction including long-standing fatigue. JJ Clin Virol. 2006 Dec;37(suppl 1):S33-8. Abstract

73. Hickie I, Davenport T, Wakefield D, et al. Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study. BMJ. 2006 Sep 16;333(7568):575.Full text  Abstract

74. Nyland M, Naess H, Birkeland JS, et al. Longitudinal follow-up of employment status in patients with chronic fatigue syndrome after mononucleosis. BMJ Open. 2014 Nov 26;4(11):e005798.Full text  Abstract

75. Thompson DF, Ramos CL. Antibiotic-induced rash in patients with infectious mononucleosis. Ann Pharmacother. 2017 Feb;51(2):154-62. Abstract

76. Farley DR, Zietlow SP, Bannon MP, et al. Spontaneous rupture of the spleen due to infectious mononucleosis. Mayo Clin Proc. 1992 Sep;67(9):846-53. Abstract

77. Bartlett A, Williams R, Hilton M. Splenic rupture in infectious mononucleosis: a systematic review of published case reports. Injury. 2016 Mar;47(3):531-8. Abstract

78. Stephenson JT, DuBois JJ. Nonoperative management of spontaneous splenic rupture in infectious mononucleosis: a case report and review of the literature. Pediatrics. 2007 Aug;120(2):e432-5. Abstract

79. Heo DH, Baek DY, Oh SM, et al. Splenic infarction associated with acute infectious mononucleosis due to Epstein-Barr virus infection. J Med Virol. 2017 Feb;89(2):332-6. Abstract

80. Ali K, Lawthom C. Epstein-Barr virus-associated cerebellar ataxia. BMJ Case Rep. 2013 Apr 22;2013.Full text  Abstract

81. Fernandez-Pol S, Silva O, Natkunam Y. Defining the elusive boundaries of chronic active Epstein-Barr virus infection. Haematologica. 2018 Jun;103(6):924-7.Full text  Abstract

82. Kimura H, Hoshino Y, Kanegane H, et al. Clinical and virologic characteristics of chronic active Epstein-Barr virus infection. Blood. 2001 Jul 15;98(2):280-6.Full text  Abstract

83. Thacker EL, Mirzaei F, Ascherio A. Infectious mononucleosis and risk for multiple sclerosis: a meta-analysis. Ann Neurol. 2006 Mar;59(3):499-503. Abstract

84. Sheik-Ali S. Infectious mononucleosis and multiple sclerosis - updated review on associated risk. Mult Scler Relat Disord. 2017 May;14:56-9. Abstract

85. Belbasis L, Bellou V, Evangelou E, et al. Environmental factors and risk of multiple sclerosis: findings from meta-analyses and Mendelian randomization studies. Mult Scler. 2020 Apr;26(4):397-404.Full text  Abstract

86. Jacobs BM, Giovannoni G, Cuzick J, et al. Systematic review and meta-analysis of the association between Epstein-Barr virus, multiple sclerosis and other risk factors. Mult Scler. 2020 Oct;26(11):1281-97.Full text  Abstract

87. Houen G, Trier NH. Epstein-Barr virus and systemic autoimmune diseases. Front Immunol. 2020;11:587380.Full text  Abstract

88. Li ZX, Zeng S, Wu HX, et al. The risk of systemic lupus erythematosus associated with Epstein-Barr virus infection: a systematic review and meta-analysis. Clin Exp Med. 2019 Feb;19(1):23-36.Full text  Abstract

89. Bakkalci D, Jia Y, Winter JR, et al. Risk factors for Epstein Barr virus-associated cancers: a systematic review, critical appraisal, and mapping of the epidemiological evidence. J Glob Health. 2020 Jun;10(1):010405.Full text  Abstract

90. Kanda T, Yajima M, Ikuta K. Epstein-Barr virus strain variation and cancer. Cancer Sci. 2019 Apr;110(4):1132-9.Full text  Abstract

91. Candy B, Chalder T, Cleare AJ, et al. Recovery from infectious mononucleosis: a case for more than symptomatic therapy? A systematic review. Br J Gen Pract. 2002 Oct;52(483):844-51.Full text  Abstract

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93. Vindegaard N, Petersen LV, Lyng-Rasmussen BI, et al. Infectious mononucleosis as a risk factor for depression: a nationwide cohort study. Brain Behav Immun. 2021 May;94:259-65.Full text  Abstract

94. Kim A, Yang HR, Moon JS, et al. Epstein-Barr virus infection with acute acalculous cholecystitis. Pediatr Gastroenterol Hepatol Nutr. 2014 Mar;17(1):57-60.Full text  Abstract

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96. Moretti M, Lava SAG, Zgraggen L, et al. Acute kidney injury in symptomatic primary Epstein-Barr virus infectious mononucleosis: systematic review. J Clin Virol. 2017 Jun;91:12-7. Abstract

97. Marsh RA. Epstein-Barr virus and hemophagocytic lymphohistiocytosis. Front Immunol. 2017;8:1902.Full text  Abstract

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