Defined as a serum sodium concentration of >145 mmol/L.
Most common presentations are the patient in the intensive care unit who is unable to drink water, has a large urine or stool output, and is unable to concentrate urine normally (usually due to renal failure), and the older nursing home resident, usually with dementia.
Underlying aetiology is varied and includes free water losses, inadequate free water intake, or, more rarely, sodium overload.
Examination should focus on volume status, particularly noting severe hypovolaemia, which generally needs urgent correction.
Treatment is directed at addressing the underlying cause, as well as replacing free water deficit and ongoing losses while monitoring serum sodium concentration. It is important not to correct the serum sodium concentration too rapidly in cases of chronic hypernatraemia.
An electrolyte imbalance consisting of a rise in serum sodium concentration. Hypernatraemia is defined as a serum sodium concentration of >145 mmol/L (normal serum sodium concentration is in the range of 135-145 mmol/L). Severe hypernatraemia has variously been defined as a serum sodium concentration of >152 mmol/L, >155 mmol/L, or >160 mmol/L; there is no consensus as to the exact level.
Hypernatraemia represents a deficit of water relative to sodium and can result from a number of causes, including free water losses, inadequate free water intake, and, more rarely, sodium overload. Unlike hyponatraemia, hypernatraemia is always associated with serum hyperosmolality.
History and exam
- presence of risk factors
- hospital stay
- older age/nursing home resident
- central nervous system manifestations
- diarrhoea or vomiting
- impaired thirst
- weight loss
- orthostatic hypotension
- decreased jugular venous pressure
- other signs of hypovolaemia
- polyuria, polydipsia, increased thirst
Ramin Sam, MD
Clinical Professor of Medicine
San Francisco General Hospital
University of California San Francisco
RS declares that he has no competing interests.
Todd S. Ing, MBBS, FRCP
Professor Emeritus of Medicine
Loyola University Chicago
TSI declares that he has no competing interests.
Gregor Lindner, MD
Department of Internal & Emergency Medicine
Hirslanden Klinik Im Park
GL is an author of a number of references cited in this topic.
Michael Moritz, MD
Professor of Pediatrics
University of Pittsburgh Medical School
Children's Hospital of Pittsburgh of UPMC
MLM is the author of a number of references cited in this topic.
Judith H. Veis, MD
Washington Hospital Center
JHV declares that she has no competing interests.
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