References
Key articles
National Institute for Health and Care Excellence. Diabetic foot problems: prevention and management. Oct 2019 [internet publication].Full text
Schaper NC, van Netten JJ, Apelqvist J, et al. Practical guidelines on the prevention and management of diabetes-related foot disease (IWGDF 2023 update). Diabetes Metab Res Rev. 2024 Mar;40(3):e3657.Full text Abstract
American Diabetes Association. Standards of care in diabetes - 2024 [internet publication].Full text
Reference articles
1. van Netten JJ, Bus SA, Apelqvist J, et al. Definitions and criteria for diabetes-related foot disease (IWGDF 2023 update). Diabetes Metab Res Rev. 2024 Mar;40(3):e3654.Full text Abstract
2. Armstrong DG, Tan TW, Boulton AJM, et al. Diabetic foot ulcers: a review. JAMA. 2023 Jul 3;330(1):62-75. Abstract
3. Diabetes UK. Number people living diabetes living in the UK tops 5 million first time. 2023 [internet publication].Full text
4. GBD 2021 Diabetes Collaborators. Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2023 Jul 15;402(10397):203-34.Full text Abstract
5. Centers for Disease Control and Prevention. US diabetes surveillance system [internet publication].Full text
6. Centers for Disease Control and Prevention. National diabetes statistics report. May 2024 [internet publication].Full text
7. Monteiro-Soares M, Hamilton EJ, Russell DA, et al. Guidelines on the classification of foot ulcers in people with diabetes (IWGDF 2023 update). Diabetes Metab Res Rev. 2024 Mar;40(3):e3648.Full text Abstract
8. Zhang Y, Lazzarini PA, McPhail SM, et al. Global disability burdens of diabetes-related lower-extremity complications in 1990 and 2016. Diabetes Care. 2020 May;43(5):964-74.Full text Abstract
9. National Institute for Health and Care Excellence. Diabetic foot problems: prevention and management. Oct 2019 [internet publication].Full text
10. Barshes NR, Sigireddi M, Wrobel JS, et al. The system of care for the diabetic foot: objectives, outcomes, and opportunities. Diabet Foot Ankle. 2013 Oct 10;4:21847.Full text Abstract
11. Fitridge R, Chuter V, Mills J, et al. The intersocietal IWGDF, ESVS, SVS guidelines on peripheral artery disease in people with diabetes and a foot ulcer. Diabetes Metab Res Rev. 2024 Mar;40(3):e3686.Full text Abstract
12. Boyko EJ, Ahroni JH, Cohen V, et al. Prediction of diabetic foot ulcer occurrence using commonly available clinical information: the Seattle Diabetic Foot Study. Diabetes Care. 2006 Jun;29(6):1202-7.Full text Abstract
13. NHS Digital. National diabetes foot care audit (NDFA) sixth national report: England and Wales July 2014-March 2021. May 2022 [internet publication].Full text
14. Boulton AJ, Armstrong DG, Albert SF, et al. Comprehensive foot examination and risk assessment: a report of the task force of the foot care interest group of the American Diabetes Association, with endorsement by the American Association of Clinical Endocrinologists. Diabetes Care. 2008 Aug;31(8):1679-85.Full text Abstract
15. Prompers L, Huijberts M, Apelqvist J, et al. Delivery of care to diabetic patients with foot ulcers in daily practice: results of the Eurodiale Study, a prospective cohort study. Diabet Med. 2008 Jun;25(6):700-7. Abstract
16. Lavery LA, Armstrong DG, Wunderlich RP, et al. Risk factors for foot infections in individuals with diabetes. Diabetes Care. 2006 Jun;29(6):1288-93.Full text Abstract
17. LoGerfo FW, Coffman JD. Current concepts: vascular and microvascular disease of the foot in diabetes - implications for foot care. N Engl J Med. 1984 Dec 20;311(25):1615-9. Abstract
18. Gallagher KA, Mills JL, Armstrong DG, et al. Current status and principles for the treatment and prevention of diabetic foot ulcers in the cardiovascular patient population: a scientific statement from the American Heart Association. Circulation. 2024 Jan 23;149(4):e232-53.Full text Abstract
19. Holman N, Young RJ, Jeffcoate WJ. Variation in the recorded incidence of amputation of the lower limb in England. Diabetologia. 2012 Jul;55(7):1919-25.Full text Abstract
20. Leggetter S, Chaturvedi N, Fuller JH, et al. Ethnicity and risk of diabetes-related lower extremity amputation: a population-based, case-control study of African Caribbeans and Europeans in the United kingdom. Arch Intern Med. 2002 Jan 14;162(1):73-8.Full text Abstract
21. Armstrong DG, Boulton AJ, Bus SA. Diabetic foot ulcers and their recurrence. N Engl J Med. 2017 Jun 15;376(24):2367-75. Abstract
22. Lavery LA, Peters EJ, Williams JR, et al. Reevaluating the way we classify the diabetic foot: restructuring the diabetic foot risk classification system of the International Working Group on the Diabetic Foot. Diabetes Care. 2008 Jan;31(1):154-6.Full text Abstract
23. Crawford F, Cezard G, Chappell FM, et al. A systematic review and individual patient data meta-analysis of prognostic factors for foot ulceration in people with diabetes: the international research collaboration for the prediction of diabetic foot ulcerations (PODUS). Health Technol Assess. 2015 Jul;19(57):1-210.Full text Abstract
24. Bus SA, Sacco ICN, Monteiro-Soares M, et al. Guidelines on the prevention of foot ulcers in persons with diabetes (IWGDF 2023 update). Diabetes Metab Res Rev. 2024 Mar;40(3):e3651.Full text Abstract
25. O'Hare AM, Glidden DV, Fox CS, et al. High prevalence of peripheral arterial disease in persons with renal insufficiency: results from the National Health and Nutrition Examination Survey 1999-2000. Circulation. 2004 Jan 27;109(3):320-3.Full text Abstract
26. Krishnan AV, Kiernan MC. Neurological complications of chronic kidney disease. Nat Rev Neurol. 2009 Oct;5(10):542-51. Abstract
27. Dallimore SM, Kaminski MR. Tendon lengthening and fascia release for healing and preventing diabetic foot ulcers: a systematic review and meta-analysis. J Foot Ankle Res. 2015 Jul 30:8:33.Full text Abstract
28. Bus SA, Armstrong DG, Crews RT, et al. Guidelines on offloading foot ulcers in persons with diabetes (IWGDF 2023 update). Diabetes Metab Res Rev. 2024 Mar;40(3):e3647.Full text Abstract
29. Wukich DK, Schaper NC, Gooday C, et al. Guidelines on the diagnosis and treatment of active Charcot neuro-osteoarthropathy in persons with diabetes mellitus (IWGDF 2023). Diabetes Metab Res Rev. 2024 Mar;40(3):e3646.Full text Abstract
30. Sohn MW, Budiman-Mak E, Lee TA, et al. Significant J-shaped association between body mass index (BMI) and diabetic foot ulcers. Diabetes Metab Res Rev. 2011 May;27(4):402-9. Abstract
31. Pinzur M, Freeland R, Juknelis D. The association between body mass index and foot disorders in diabetic patients. Foot Ankle Int. 2005 May;26(5):375-7. Abstract
32. Chen L, Ma W, Tang W, et al. Prevalence of obstructive sleep apnea in patients with diabetic foot ulcers. Front Endocrinol (Lausanne). 2020 Jul 14:11:416.Full text Abstract
33. Fernández-Torres R, Ruiz-Muñoz M, Pérez-Belloso AJ, et al. Is there an association between sleep disorders and diabetic foot? A Scoping Review. J Clin Med. 2021 Jun 7;10(11):2530.Full text Abstract
34. Lin J, Song H, Liang M, et al. Advances in the study of OSA and diabetic foot. Diabetol Metab Syndr. 2022 May 12;14(1):70.Full text Abstract
35. Gouveri E, Steiropoulos P, Papanas N. Does obstructive sleep apnoea syndrome influence the development and treatment of diabetic foot? a brief narrative review. Int J Low Extrem Wounds. 2022 Jul 14:15347346221113992. Abstract
36. Schaper NC, van Netten JJ, Apelqvist J, et al. Practical guidelines on the prevention and management of diabetes-related foot disease (IWGDF 2023 update). Diabetes Metab Res Rev. 2024 Mar;40(3):e3657.Full text Abstract
37. American Diabetes Association. Standards of care in diabetes - 2024 [internet publication].Full text
38. Matheson EM, Bragg SW, Blackwelder RS. Diabetes-related foot infections: diagnosis and treatment. Am Fam Physician. 2021 Oct 1;104(4):386-94.Full text Abstract
39. Association of British Clinical Diabetologists. JBDS 11 management of adults with diabetes on dialysis. Mar 2023 [internet publication].Full text
40. Senneville É, Albalawi Z, van Asten SA, et al. IWGDF/IDSA guidelines on the diagnosis and treatment of diabetes-related foot infections (IWGDF/IDSA 2023). Diabetes Metab Res Rev. 2024 Mar;40(3):e3687.Full text Abstract
41. National Institute for Health and Care Excellence. Peripheral arterial disease: diagnosis and management. December 2020 [internet publication].Full text
42. Bonnet JB, Sultan A. Narrative review of the relationship between CKD and diabetic foot ulcer. Kidney Int Rep. 2022 Mar;7(3):381-8.Full text Abstract
43. Rubio JA, Jiménez S, Lázaro-Martínez JL. Mortality in patients with diabetic foot ulcers: causes, risk factors, and their association with evolution and severity of ulcer. J Clin Med. 2020 Sep 18;9(9):3009.Full text Abstract
44. Anderson JL, Halperin JL, Albert NM, et al. Management of patients with peripheral artery disease (compilation of 2005 and 2011 ACCF/AHA guideline recommendations): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2013 Apr 2;127(13):1425-43.Full text Abstract
45. Ince P, Abbas ZG, Lutale JK, et al. Use of the SINBAD classification system and score in comparing outcome of foot ulcer management on three continents. Diabetes Care. 2008 May;31(5):964-7.Full text Abstract
46. NHS Digital. National diabetes foot care audit [internet publication].Full text
47. Butalia S, Palda VA, Sargeant RJ, et al. Does this patient with diabetes have osteomyelitis of the lower extremity? JAMA. 2008 Feb 20;299(7):806-13. Abstract
48. Lavery LA, Armstrong DG, Murdoch DP, et al. Validation of the Infectious Diseases Society of America's diabetic foot infection classification system. Clin Infect Dis. 2007 Feb 15;44(4):562-5.Full text Abstract
49. Bravo-Molina A, Linares-Palomino JP, Vera-Arroyo B, et al. Inter-observer agreement of the Wagner, University of Texas and PEDIS classification systems for the diabetic foot syndrome. Foot Ankle Surg. 2018 Feb;24(1):60-4.Full text Abstract
50. Monteiro-Soares M, Martins-Mendes D, Vaz-Carneiro A, et al. Lower-limb amputation following foot ulcers in patients with diabetes: classification systems, external validation and comparative analysis. Diabetes Metab Res Rev. 2015 Jul;31(5):515-29. Abstract
51. Boulton AJ, Armstrong DG, Kirsner RS, et al; American Diabetes Association. Diagnosis and management of diabetic foot complications. 2018 [internet publication].Full text
52. American Limb Preservation Society. Nutrition interventions in adults with diabetic foot ulcers. Sep 2023 [internet publication].Full text
53. Boyko EJ, Zelnick LR, Braffett BH, et al. Risk of foot ulcer and lower-extremity amputation among participants in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study. Diabetes Care. 2022 Feb 1;45(2):357-64.Full text Abstract
54. Arnott C, Huang Y, Neuen BL, et al. The effect of canagliflozin on amputation risk in the CANVAS program and the CREDENCE trial. Diabetes Obes Metab. 2020 Oct;22(10):1753-66.Full text Abstract
55. Chen P, Vilorio NC, Dhatariya K, et al. Guidelines on interventions to enhance healing of foot ulcers in people with diabetes (IWGDF 2023 update). Diabetes Metab Res Rev. 2024 Mar;40(3):e3644.Full text Abstract
56. Roehrs H, Stocco JG, Pott F, et al. Dressings and topical agents containing hyaluronic acid for chronic wound healing. Cochrane Database Syst Rev. 2023 Jul 27;7(7):CD012215.Full text Abstract
57. National Institute for Health and Care Excellence. UrgoStart for treating diabetic foot ulcers and leg ulcers. Apr 2023 [internet publication].Full text
58. Edmonds M, Lázaro-Martínez JL, Alfayate-García JM, et al. Sucrose octasulfate dressing versus control dressing in patients with neuroischaemic diabetic foot ulcers (Explorer): an international, multicentre, double-blind, randomised, controlled trial. Lancet Diabetes Endocrinol. 2018 Mar;6(3):186-96. Abstract
59. Rusu A, Munteanu AC, Arbănași EM, et al. Overview of side-effects of antibacterial fluoroquinolones: new drugs versus old drugs, a step forward in the safety profile? Pharmaceutics. 2023 Mar 1;15(3):804.Full text Abstract
60. Salim M. Clinical outcomes among patients with chronic kidney disease hospitalized with diabetic foot disorders: a nationwide retrospective study. Endocrinol Diabetes Metab. 2021 Jul;4(3):e00277.Full text Abstract
61. Gilhotra RA, Rodrigues BT, Vangaveti VN, et al. Prevalence and risk factors of lower limb amputation in patients with end-stage renal failure on dialysis: a systematic review. Int J Nephrol. 2016;2016:4870749.Full text Abstract
62. Kaminski MR, Raspovic A, McMahon LP, et al. Risk factors for foot ulceration and lower extremity amputation in adults with end-stage renal disease on dialysis: a systematic review and meta-analysis. Nephrol Dial Transplant. 2015 Oct;30(10):1747-66.Full text Abstract
63. Chin BZ, Lee P, Sia CH, et al. Diabetic foot ulcer is associated with cardiovascular-related mortality and morbidity - a systematic review and meta-analysis of 8062 patients. Endocrine. 2024 Jun;84(3):852-63. Abstract
64. Brownrigg JR, Davey J, Holt PJ, et al. The association of ulceration of the foot with cardiovascular and all-cause mortality in patients with diabetes: a meta-analysis. Diabetologia. 2012 Nov;55(11):2906-12.Full text Abstract
65. Pinto A, Tuttolomondo A, Di Raimondo D, et al. Cardiovascular risk profile and morbidity in subjects affected by type 2 diabetes mellitus with and without diabetic foot. Metabolism. 2008 May;57(5):676-82. Abstract
66. Young MJ, McCardle JE, Randall LE, et al. Improved survival of diabetic foot ulcer patients 1995-2008: possible impact of aggressive cardiovascular risk management. Diabetes Care. 2008 Nov;31(11):2143-7.Full text Abstract
67. Rovan U V, Baker N, Acker K V, et al. Comorbidities in the diabetic patient with foot problems. The Diabetic Foot Journal. 2017; 20(4):218-27.Full text
68. Xu L, Qian H, Gu J, et al. Heart failure in hospitalized patients with diabetic foot ulcers: clinical characteristics and their relationship with prognosis. J Diabetes. 2013 Dec;5(4):429-38. Abstract
69. Ahmad A, Abujbara M, Jaddou H, et al. Anxiety and depression among adult patients with diabetic foot: prevalence and associated factors. J Clin Med Res. 2018 May;10(5):411-8.Full text Abstract
70. Williams LH, Rutter CM, Katon WJ, et al. Depression and incident diabetic foot ulcers: a prospective cohort study. Am J Med. 2010 Aug;123(8):748-54.e3.Full text Abstract
71. Williams LH, Miller DR, Fincke G, et al. Depression and incident lower limb amputations in veterans with diabetes. J Diabetes Complications. 2011 May-Jun;25(3):175-82.Full text Abstract
72. Ismail K, Winkley K, Stahl D, et al. A cohort study of people with diabetes and their first foot ulcer: the role of depression on mortality. Diabetes Care. 2007 Jun;30(6):1473-9.Full text Abstract
73. Winkley K, Sallis H, Kariyawasam D, et al. Five-year follow-up of a cohort of people with their first diabetic foot ulcer: the persistent effect of depression on mortality. Diabetologia. 2012 Feb;55(2):303-10.Full text Abstract
74. Williams DT, Majeed MU, Shingler G, et al. A diabetic foot service established by a department of vascular surgery: an observational study. Ann Vasc Surg. 2012 Jul;26(5):700-6. Abstract
75. Driver VR, Madsen J, Goodman RA. Reducing amputation rates in patients with diabetes at a military medical center: the Limb Preservation Service model. Diabetes Care. 2005 Feb;28(2):248-53.Full text Abstract
76. Canavan RJ, Unwin NC, Kelly WF, et al. Diabetes- and nondiabetes-related lower extremity amputation incidence before and after the introduction of better organized diabetes foot care: continuous longitudinal monitoring using a standard method. Diabetes Care. 2008 Mar;31(3):459-63.Full text Abstract
77. Armstrong DG, Bharara M, White M, et al. The impact and outcomes of establishing an integrated interdisciplinary surgical team to care for the diabetic foot. Diabetes Metab Res Rev. 2012 Sep;28(6):514-8. Abstract
78. Mills JL, Beckett WC, Taylor SM. The diabetic foot: consequences of delayed treatment and referral. South Med J. 1991 Aug;84(8):970-4. Abstract
79. Hughes OB, Rakosi A, Macquhae F, et al. A review of cellular and acellular matrix products: indications, techniques, and outcomes. Plast Reconstr Surg. 2016 Sep;138(3 suppl):138-47S. Abstract
80. Martí-Carvajal AJ, Gluud C, Nicola S, et al. Growth factors for treating diabetic foot ulcers. Cochrane Database Syst Rev. 2015 Oct 28;(10):CD008548.Full text Abstract
81. Frykberg RG, Franks PJ, Edmonds M, et al. A multinational, multicenter, randomized, double-blinded, placebo-controlled trial to evaluate the efficacy of cyclical topical wound oxygen therapy (TWO2) in the treatment of chronic diabetic foot ulcers: the TWO2 study. Diabetes Care. 2020 Mar;43(3):616-624.Full text Abstract
82. Wenhui L, Changgeng F, Lei X, et al. Hyperbaric oxygen therapy for chronic diabetic foot ulcers: an overview of systematic reviews. Diabetes Res Clin Pract. 2021 Jun;176:108862. Abstract
83. Abidia A, Laden G, Kuhan G, et al. The role of hyperbaric oxygen therapy in ischaemic diabetic lower extremity ulcers: a double-blind randomised-controlled trial. Eur J Vasc Endovasc Surg. 2003 Jun;25(6):513-8. Abstract
84. NHS England. Evidence review: Hyperbaric oxygen therapy for diabetic lower limb ulceration refractory to best standard care. Mar 2018 [internet publication].Full text
85. Health Quality Ontario. Hyperbaric oxygen therapy for the treatment of diabetic foot ulcers: a health technology assessment. Ont Health Technol Assess Ser. 2017 May 12;17(5):1-142.Full text Abstract
86. Game F, Jeffcoate W, Tarnow L, et al. LeucoPatch system for the management of hard-to-heal diabetic foot ulcers in the UK, Denmark, and Sweden: an observer-masked, randomised controlled trial. Lancet Diabetes Endocrinol. 2018 Sep 19;6(11):870-8. Abstract
87. National Institute for Health and Care Excellence. 3C Patch for treating diabetic foot ulcers. Mar 2022 [internet publication].Full text
88. Ramanujam CL, Zgonis T. Use of local flaps for soft-tissue closure in diabetic foot wounds: a systematic review. Foot Ankle Spec. 2019 Jun;12(3):286-93. Abstract
89. Armstrong DG, Swerdlow MA, Armstrong AA, et al. Five year mortality and direct costs of care for people with diabetic foot complications are comparable to cancer. J Foot Ankle Res. 2020 Mar 24;13(1):16.Full text Abstract
90. Lam K, van Asten SA, Nguyen T, et al. Diagnostic accuracy of probe to bone to detect osteomyelitis in the diabetic foot: a systematic review. Clin Infect Dis. 2016 Oct 1;63(7):944-8.Full text Abstract
91. Tone A, Nguyen S, Devemy F, et al. Six-week versus twelve-week antibiotic therapy for nonsurgically treated diabetic foot osteomyelitis: a multicenter open-label controlled randomized study. Diabetes Care. 2015 Feb;38(2):302-7.Full text Abstract
92. Gariani K, Pham TT, Kressmann B, et al. Three weeks versus six weeks of antibiotic therapy for diabetic foot osteomyelitis: a prospective, randomized, noninferiority pilot trial. Clin Infect Dis. 2021 Oct 5;73(7):e1539-45. Abstract
93. Baglioni P, Malik M, Okosieme OE. Acute Charcot foot. BMJ. 2012 Mar 14;344:e1397. Abstract
94. Game FL, Catlow R, Jones GR, et al. Audit of acute Charcot's disease in the UK: the CDUK study. Diabetologia. 2012 Jan;55(1):32-5.Full text Abstract
95. Rogers LC, Frykberg RG, Armstrong DG, et al. The Charcot foot in diabetes. Diabetes Care. 2011 Sep;34(9):2123-9.Full text Abstract
96. Berceli SA, Hevelone ND, Lipsitz SR, et al. Surgical and endovascular revision of infrainguinal vein bypass grafts: analysis of midterm outcomes from the PREVENT III trial. J Vasc Surg. 2007 Dec;46(6):1173-9.Full text Abstract
97. Miller JD, Salloum M, Button A, et al. How can I maintain my patient with diabetes and history of foot ulcer in remission? Int J Low Extrem Wounds. 2014 Dec;13(4):371-7. Abstract
98. Armstrong DG, Mills JL. Toward a change in syntax in diabetic foot care: prevention equals remission. J Am Podiatr Med Assoc. 2013 Mar-Apr;103(2):161-2. Abstract
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