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Dengue fever

Última revisão: 18 Jun 2025
Última atualização: 03 May 2024

Resumo

Определение

Анамнез и осмотр

Ключевые диагностические факторы

  • fever
  • skin flushing/rash
  • myalgia/arthralgia/headache
  • hemorrhagic signs
  • lethargy/restlessness
  • hepatomegaly
  • abdominal distention
  • pleuritic chest pain, dyspnea, cough
  • signs of circulatory collapse
Полная информация

Другие диагностические факторы

  • gastrointestinal symptoms
  • upper respiratory tract symptoms
Полная информация

Факторы риска

  • residence in/travel from dengue-endemic region within the past 2 weeks
  • children ages 1 to 5 years
  • older age
  • pregnancy
  • presence of comorbidities
  • exposure to infected blood products
  • living with uncovered water container
  • female sex
  • obesity
  • blood group O
Полная информация

Диагностические исследования

Исследования, которые показаны в первую очередь

  • CBC
  • liver function tests (LFTs)
  • serum albumin level
  • serology
  • reverse transcription-polymerase chain reaction (RT-PCR)
  • nonstructural protein 1 (NS1) detection
Полная информация

Исследования, проведение которых нужно рассмотреть

  • coagulation studies
  • chest x-ray
  • abdominal ultrasound
Полная информация

Неотложные исследования

  • reverse transcription-insulated isothermal polymerase chain reaction (RT-iiPCR)

Алгоритм лечения

Острый

WHO group C (established warning signs)

WHO group B (developing warning signs)

WHO group A (no warning signs)

Составители

Авторы

S.A.M. Kularatne, MBBS, MD, MRCP (UK), FRCP (London), FCCP (SL)
S.A.M. Kularatne

Senior Professor

Chair of Medicine

Department of Medicine

Faculty of Medicine

University of Peradeniya

Peradeniya

Sri Lanka

Раскрытие информации

SAMK is an author of several references cited in this topic.

Рецензенты

John McBride, PhD, MBBS, DTM&H, FRACP, FRCPA

Professor of Medicine

James Cook University

Cairns Base Hospital Clinical School

Cairns

Australia

Раскрытие информации

JM declares that he has no competing interests.

Michael Jacobs, MA, PhD, MBBS, FRCP, DTM&H

Consultant

Infectious Diseases

Royal Free Hampstead NHS Trust

London

UK

Раскрытие информации

MJ declares that he has no competing interests.

Stephen Gluckman, MD

Professor of Medicine

Medical Director

Penn Global Medicine

Penn Center for Primary Care

PA

Раскрытие информации

SG declares that he has no competing interests.

Список литературы

Our in-house evidence and editorial teams collaborate with international expert contributors and peer reviewers to ensure that we provide access to the most clinically relevant information possible.

Основные статьи

World Health Organization, Regional Office for South-East Asia. Comprehensive guidelines for prevention and control of dengue and dengue haemorrhagic fever - revised and expanded edition. 2011 [internet publication].Полный текст

World Health Organization, Special Programme for Research and Training in Tropical Diseases (TDR). Dengue: guidelines for diagnosis, treatment, prevention and control. New edition. 2009 [internet publication].Полный текст

Guo C, Zhou Z, Wen Z, et al. Global epidemiology of dengue outbreaks in 1990-2015: a systematic review and meta-analysis. Front Cell Infect Microbiol. 2017 Jul 12;7:317.Полный текст  Аннотация

Simmons CP, Farrar JJ, Nguyen VV, et al. Dengue. N Engl J Med. 2012;366:1423-1432. Аннотация

Centers for Disease Control and Prevention. Dengue: treatment. May 2019 [internet publication].Полный текст

Статьи, указанные как источники

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