Bell's palsy

References

Key articles

Baugh RF, Basura GJ, Ishii LE, et al. Clinical practice guideline: Bell's palsy. Otolaryngol Head Neck Surg. 2013 Nov;149(3 Suppl):S1-27.Full text  Abstract

Gronseth GS, Paduga R; American Academy of Neurology. Evidence-based guideline update: steroids and antivirals for Bell palsy. Neurology. 2012 (reaffirmed 2023) Nov 27;79(22):2209-13.Full text  Abstract

Madhok VB, Gagyor I, Daly F, et al. Corticosteroids for Bell's palsy (idiopathic facial paralysis). Cochrane Database Syst Rev. 2016;(7):CD001942.Full text  Abstract

Gagyor I, Madhok VB, Daly F, et al. Antiviral treatment for Bell's palsy (idiopathic facial paralysis). Cochrane Database Syst Rev. 2019 Sep 5;9:CD001869.Full text  Abstract

Gantz BJ, Rubinstein JT, Gidley P, et al. Surgical management of Bell palsy. Laryngoscope. 1999 Aug;109(8):1177-88. Abstract

Reference articles

1. Peitersen E. The natural history of Bell palsy. Am J Otol. 1982 Oct;4(2):107-11. Abstract

2. Dong SH, Jung AR, Jung J, et al. Recurrent Bell's palsy. Clin Otolaryngol. 2019 May;44(3):305-12. Abstract

3. Peitersen E. Bell palsy: the spontaneous course of 2,500 peripheral facial nerve palsies of different etiologies. Acta Otolaryngol Suppl. 2002;(549):4-30. Abstract

4. Jowett N, Hadlock TA. Contemporary management of Bell palsy. Facial Plast Surg. 2015 Apr;31(2):93-102. Abstract

5. House JW, Brackmann DE. Facial nerve grading system. Otolaryngol Head Neck Surg. 1985 Apr;93(2):146-7. Abstract

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7. Banks CA, Bhama PK, Park J, et al. Clinician-graded electronic facial paralysis assessment: the eFACE. Plast Reconstr Surg. 2015 Aug;136(2):223e-30e. Abstract

8. Malka R, Miller M, Guarin D, et al. Reliability between in-person and still photograph assessment of facial function in facial paralysis using the eFACE facial grading system. Facial Plast Surg Aesthet Med. 2021 Sep;23(5):344-49.Full text  Abstract

9. Banks CA, Jowett N, Hadlock TA. Test-retest reliability and agreement between in-person and video assessment of facial mimetic function using the eFACE facial grading system. JAMA Facial Plast Surg. 2017 May 1;19(3):206-11.Full text  Abstract

10. Zaidman M, Novak CB, Borschel GH, et al. Assessment of eye closure and blink with facial palsy: a systematic literature review. J Plast Reconstr Aesthet Surg. 2021 Jul;74(7):1436-45. Abstract

11. Benatar M, Edlow J. The spectrum of cranial neuropathy in patients with Bell's palsy. Arch Intern Med. 2004 Nov 22;164(21):2383-5. Abstract

12. May M, Hardin WB, Sullivan J, et al. Natural history of Bell palsy: the salivary flow test and other prognostic indicators. Laryngoscope. 1976 May;86(5):704-12. Abstract

13. Hauser WA, Karnes WE, Annis J, et al. Incidence and prognosis of Bell palsy in the population of Rochester, Minnesota. Mayo Clin Proc. 1971 Apr;46(4):258-64. Abstract

14. Yanagihara N. Incidence of Bell palsy. Ann Otol Rhinol Laryngol. 1988 Nov-Dec;137:3-4. Abstract

15. Evangelista V, Gooding MS, Pereira L. Bell's palsy in pregnancy. Obstet Gynecol Surv. 2019 Nov;74(11):674-8. Abstract

16. Fuzi J, Spencer S, Seckold E, et al. Bell's palsy during pregnancy and the post-partum period: a contemporary management approach. Am J Otolaryngol. 2021 May-Jun;42(3):102914. Abstract

17. Gaudin RA, Remenschneider AK, Phillips K, et al. Facial palsy after dental procedures - Is viral reactivation responsible? J Craniomaxillofac Surg. 2017 Jan;45(1):71-5. Abstract

18. Murakami S, Mizobuchi M, Nakashiro Y, et al. Bell palsy and herpes simplex virus: identification of viral DNA in endoneurial fluid and muscle. Ann Intern Med. 1996;124(Part 1):27-30. Abstract

19. Esaki S, Yamano K, Katsumi S, et al. Facial nerve palsy after reactivation of herpes simplex virus type 1 in diabetic mice. Laryngoscope. 2015 Apr;125(4):E143-8. Abstract

20. Kisaki H, Hato N, Mizobuchi M, et al. Role of T-lymphocyte subsets in facial nerve paralysis owing to the reactivation of herpes simplex virus type 1. Acta Otolaryngol. 2005 Mar;125(3):316-21. Abstract

21. Gorodezky C, Carranza JM, Bustamante A, et al. The HLA system and T-cell subsets in Bell palsy. Acta Otolaryngol. 1991;111(6):1070-4. Abstract

22. Tekgul H, Polat M, Serdaroglu G, et al. Lymphocyte subsets in Bell palsy: immune pathogenesis and outcome prediction. Pediatr Neurol. 2004 Oct;31(4):258-60. Abstract

23. Alshami S, Hodge D, Bradley E, The epidemiology and surgical outcomes of facial nerve palsy in a population-based cohort. Invest. Ophthalmol. Vis. Sci. 2017 June;58(8):3848.Full text

24. Gupta S, Jawanda MK. Surge of Bell's palsy in the era of COVID-19: systematic review. Eur J Neurol. 2022 Aug;29(8):2526-43.Full text  Abstract

25. Estakhr M, Tabrizi R, Ghotbi Z, et al. Is facial nerve palsy an early manifestation of COVID-19? A literature review. Am J Med Sci. 2022 Sep;364(3):264-73.Full text  Abstract

26. Gupta S, Jawanda MK, Taneja N, et al. A systematic review of Bell's palsy as the only major neurological manifestation in COVID-19 patients. J Clin Neurosci. 2021 Aug;90:284-92. Abstract

27. Shafiq A, Salameh MA, Laswi I, et al. Neurological immune-related adverse events after COVID-19 vaccination: a systematic review. J Clin Pharmacol. 2022 Mar;62(3):291-303.Full text  Abstract

28. Garg RK, Paliwal VK. Spectrum of neurological complications following COVID-19 vaccination. Neurol Sci. 2022 Jan;43(1):3-40.Full text  Abstract

29. Cirillo N, Doan R. The association between COVID-19 vaccination and Bell's palsy. Lancet Infect Dis. 2022 Jan;22(1):5-6. Abstract

30. Shemer A, Pras E, Einan-Lifshitz A, et al. Association of COVID-19 Vaccination and Facial Nerve Palsy: A Case-Control Study. JAMA Otolaryngol Head Neck Surg. 2021 Aug 1;147(8):739-743.Full text  Abstract

31. Townsend JJ, Collins PK. Peripheral nervous system demyelination with herpes simplex virus. J Neuropathol Exp Neurol. 1986 Jul;45(4):419-25. Abstract

32. Fisch U. Surgery for Bell's palsy. Arch Otolaryngol. 1981 Jan;107(1):1-11. Abstract

33. Mutsch M, Zhou W, Rhodes P, et al. Use of the inactivated intranasal influenza vaccine and the risk of Bell palsy in Switzerland. N Engl J Med. 2004 Feb 26;350(9):896-903. Abstract

34. Holland NJ, Weiner GM. Recent developments in Bell's palsy. BMJ. 2004 Sep 4;329(7465):553-7.Full text  Abstract

35. Brandenburg NA, Annegers JF. Incidence and risk factors for Bell palsy in Laredo, Texas: 1974-1982. Neuroepidemiology. 1993;12(6):313-25. Abstract

36. Abraham-Inpijn L, Devriese PP, Hart AA. Predisposing factors in Bell palsy: a clinical study with reference to diabetes mellitus, hypertension, clotting mechanism and lipid disturbance. Clin Otolaryngol Allied Sci. 1982 Apr;7(2):99-105. Abstract

37. Gilden DH. Clinical practice. Bell's palsy. N Engl J Med. 2004 Sep 23;351(13):1323-31. Abstract

38. Gilden D, Cohrs RJ, Mahalingam R, et al. Neurological disease produced by varicella zoster virus reactivation without rash. Curr Top Microbiol Immunol. 2010;342:243-53.Full text  Abstract

39. Chweya CM, Anzalone CL, Driscoll CLW, et al. For whom the Bell's toll: recurrent facial nerve paralysis, a retrospective study and systematic review of the literature. Otol Neurotol. 2019 Apr;40(4):517-28. Abstract

40. Baugh RF, Basura GJ, Ishii LE, et al. Clinical practice guideline: Bell's palsy. Otolaryngol Head Neck Surg. 2013 Nov;149(3 Suppl):S1-27.Full text  Abstract

41. Pacheco A, Rutler O, Valenzuela I, et al. Positive tests for Lyme disease and emergency department visits for Bell's palsy patients. J Emerg Med. 2020 Dec;59(6):820-7. Abstract

42. American Academy of Pediatrics – Section on Rheumatology. Five things physicians and patients should question. Choosing Wisely, an initiative of the ABIM Foundation. 2022 [internet publication].Full text

43. American College of Rheumatology – Pediatric Rheumatology. Five things physicians and patients should question. Choosing Wisely, an initiative of the ABIM Foundation. 2021 [internet publication].Full text

44. American College of Radiology. ACR appropriateness criteria: cranial neuropathy. 2022 [internet publication].Full text

45. Guntinas-Lichius O, Volk GF, Olsen KD, et al. Facial nerve electrodiagnostics for patients with facial palsy: a clinical practice guideline. Eur Arch Otorhinolaryngol. 2020 Jul;277(7):1855-74.Full text  Abstract

46. Butler DP, De la Torre A, Borschel GH, et al. An international collaborative standardizing patient-centered outcome measures in mediatric facial palsy. JAMA Facial Plast Surg. 2019 Sep 1;21(5):351-8.Full text  Abstract

47. Fieux M, Franco-Vidal V, Devic P, et al. French society of ENT (SFORL) guidelines. Management of acute Bell's palsy. Eur Ann Otorhinolaryngol Head Neck Dis. 2020 Dec;137(6):483-8.Full text  Abstract

48. Gronseth GS, Paduga R; American Academy of Neurology. Evidence-based guideline update: steroids and antivirals for Bell palsy. Neurology. 2012 (reaffirmed 2023) Nov 27;79(22):2209-13.Full text  Abstract

49. Sullivan FM, Swan IR, Donnan PT, et al. A randomised controlled trial of the use of aciclovir and/or prednisolone for the early treatment of Bell's palsy: the BELLS study. Health Technol Assess. 2009 Oct;13(47):iii-iv, ix-xi 1-130.Full text  Abstract

50. Hato N, Yamada H, Kohno H, et al. Valacyclovir and prednisolone treatment for Bell's palsy: a multicenter, randomized, placebo-controlled study. Otol Neurotol. 2007 Apr;28(3):408-13. Abstract

51. Engström M, Berg T, Stjernquist-Desatnik A, et al. Prednisolone and valaciclovir in Bell's palsy: a randomised, double-blind, placebo-controlled, multicentre trial. Lancet Neurol. 2008 Nov;7(11):993-1000. Abstract

52. Madhok VB, Gagyor I, Daly F, et al. Corticosteroids for Bell's palsy (idiopathic facial paralysis). Cochrane Database Syst Rev. 2016;(7):CD001942.Full text  Abstract

53. Gagyor I, Madhok VB, Daly F, et al. Antiviral treatment for Bell's palsy (idiopathic facial paralysis). Cochrane Database Syst Rev. 2019 Sep 5;9:CD001869.Full text  Abstract

54. Sullivan FM, Swan IR, Donnan PT, et al. Early treatment with prednisolone or acyclovir in Bell's palsy. N Engl J Med. 2007 Oct 18;357(16):1598-607. Abstract

55. Axelsson S, Berg T, Jonsson L, et al. Prednisolone in Bell's palsy related to treatment start and age. Otol Neurotol. 2011 Jan;32(1):141-6. Abstract

56. Axelsson S, Berg T, Jonsson L, et al. Bell's palsy - the effect of prednisolone and/or valaciclovir versus placebo in relation to baseline severity in a randomised controlled trial. Clin Otolaryngol. 2012 Aug;37(4):283-90. Abstract

57. Berg T, Bylund N, Marsk E, et al. The effect of prednisolone on sequelae in Bell's palsy. Arch Otolaryngol Head Neck Surg. 2012 May;138(5):445-9.Full text  Abstract

58. Fujiwara T, Namekawa M, Kuriyama A, et al. High-dose corticosteroids for adult Bell's palsy: systematic review and meta-analysis. Otol Neurotol. 2019 Sep;40(8):1101-8. Abstract

59. Jowett N, Gaudin RA, Banks CA, et al. Steroid use in Lyme disease-associated facial palsy is associated with worse long-term outcomes. Laryngoscope. 2017 Jun;127(6):1451-8. Abstract

60. Jalali MM, Soleimani R, Soltanipour S, et al. Pharmacological treatments of Bell's palsy in adults: a systematic review and network meta-Analysis. Laryngoscope. 2021 Jul;131(7):1615-25. Abstract

61. de Almeida JR, Al Khabori M, Guyatt GH, et al. Combined corticosteroid and antiviral treatment for Bell palsy: a systematic review and meta-analysis. JAMA. 2009 Sep 2;302(9):985-93.Full text  Abstract

62. Goudakos JK, Markou KD. Corticosteroids vs corticosteroids plus antiviral agents in the treatment of Bell palsy: a systematic review and meta-analysis. Arch Otolaryngol Head Neck Surg. 2009 Jun;135(6):558-64.Full text  Abstract

63. Quant EC, Jeste SS, Muni RH, et al. The benefits of steroids versus steroids plus antivirals for treatment of Bell's palsy: a meta-analysis. BMJ. 2009 Sep 7;339:b3354.Full text  Abstract

64. de Ru JA, van Benthem PP. Combination therapy is preferable for patients with Ramsay Hunt syndrome. Otol Neurotol. 2011 Jul;32(5):852-5. Abstract

65. Monsanto RD, Bittencourt AG, Bobato Neto NJ, et al. Treatment and prognosis of facial palsy on Ramsay Hunt syndrome: results based on a review of the literature. Int Arch Otorhinolaryngol. 2016 Oct;20(4):394-400.Full text  Abstract

66. Gantz BJ, Rubinstein JT, Gidley P, et al. Surgical management of Bell palsy. Laryngoscope. 1999 Aug;109(8):1177-88. Abstract

67. Menchetti I, McAllister K, Walker D, et al. Surgical interventions for the early management of Bell's palsy. Cochrane Database Syst Rev. 2021 Jan 26;1:CD007468.Full text  Abstract

68. May M, Klein SR, Taylor FH. Idiopathic (Bell's) facial palsy: natural history defies steroid or surgical treatment. Laryngoscope. 1985 Apr;95(4):406-9. Abstract

69. Lee SY, Seong J, Kim YH. Clinical implication of facial nerve decompression in complete Bell's palsy: a systematic review and meta-analysis. Clin Exp Otorhinolaryngol. 2019 Nov;12(4):348-59.Full text  Abstract

70. Casazza GC, Schwartz SR, Gurgel RK. Systematic review of facial nerve outcomes after middle fossa decompression and transmastoid decompression for Bell's palsy with complete facial paralysis. Otol Neurotol. 2018 Dec;39(10):1311-8. Abstract

71. Sohrab M, Abugo U, Grant M, et al. Management of the eye in facial paralysis. Facial Plast Surg. 2015 Apr;31(2):140-4.Full text  Abstract

72. American Academy of Ophthalmology. Management of exposure keratopathy.​ Apr 2014 [internet publication].Full text

73. Beutner KR, Friedman DJ, Forszpaniak C, et al. Valaciclovir compared with acyclovir for improved therapy for herpes zoster in immunocompetent adults. Antimicrob Agents Chemother. 1995 Jul;39(7):1546-53.Full text  Abstract

74. Borodic G, Bartley M, Slattery W, et al. Botulinum toxin for aberrant facial nerve regeneration: double-blind, placebo-controlled trial using subjective endpoints. Plast Reconstr Surg. 2005 Jul;116(1):36-43. Abstract

75. Fuzi J, Taylor A, Sideris A, et al. Does botulinum toxin therapy improve quality of life in patients with facial palsy? Aesthetic Plast Surg. 2020 Oct;44(5):1811-9. Abstract

76. de Sanctis Pecora C, Shitara D. Botulinum toxin type A to improve facial symmetry in facial palsy: a practical guideline and clinical experience. Toxins (Basel). 2021 Feb 18;13(2).Full text  Abstract

77. Teixeira LJ, Valbuza JS, Prado GF, et al. Physical therapy for Bell's palsy (idiopathic facial paralysis). Cochrane Database Syst Rev. 2011;(12):CD006283.Full text  Abstract

78. Khan AJ, Szczepura A, Palmer S, et al. Physical therapy for facial nerve paralysis (Bell's palsy): an updated and extended systematic review of the evidence for facial exercise therapy. Clin Rehabil. 2022 Nov;36(11):1424-49.Full text  Abstract

79. Beurskens CH, Heymans PG, Oostendorp RA. Stability of benefits of mime therapy in sequelae of facial nerve paresis during a 1-year period. Otol Neurotol. 2006 Oct;27(7):1037-42. Abstract

80. Pourmomeny AA, Zadmehre H, Mirshamsi M, et al. Prevention of synkinesis by biofeedback therapy: a randomized clinical trial. Otol Neurotol. 2014 Apr;35(4):739-42. Abstract

81. Nicastri M, Mancini P, De Seta D, et al. Efficacy of early physical therapy in severe Bell's palsy: a randomized controlled trial. Neurorehabil Neural Repair. 2013 Jul-Aug;27(6):542-51. Abstract

82. Chen N, Zhou M, He L, et al. Acupuncture for Bell's palsy. Cochrane Database Syst Rev. 2010;(8):CD002914. Abstract

83. Yu Z, Shen M, Shang W, et al. Timing of acupuncture treatment in peripheral facial paralysis: a systematic review and meta-analysis. Comput Math Methods Med. 2021;2021:4221955.Full text  Abstract

84. Wen J, Chen X, Yang Y, et al. Acupuncture medical therapy and its underlying mechanisms: a systematic review. Am J Chin Med. 2021;49(1):1-23. Abstract

85. Zou Z. Comparison of efficacy and safety of acupuncture and moxibustion in acute phase and non-acute phase of Bell's palsy: a meta-analysis. Neuro Endocrinol Lett. 2021 Nov 30;42(7):438-45. Abstract

86. Yang LS, Zhou DF, Zheng SZ, et al. Early intervention with acupuncture improves the outcome of patients with Bell's palsy: a propensity score-matching analysis. Front Neurol. 2022;13:943453.Full text  Abstract

87. Holland NJ, Bernstein JM, Hamilton JW, et al. Hyperbaric oxygen therapy for Bell's palsy. Cochrane Database Syst Rev. 2012;(2):CD007288.Full text  Abstract

88. Racic G, Denoble PJ, Sprem N, et al. Hyperbaric oxygen as a therapy of Bell's palsy. Undersea Hyperb Med. 1997;24(1):35-8. Abstract

89. Gillman GS, Schaitkin BM, May M, et al. Bell palsy in pregnancy: a study of recovery outcomes. Otolaryngol Head Neck Surg. 2002 Jan;126(1):26-30. Abstract

90. Shmorgun D, Chan WS, Ray JG. Association between Bell's palsy in pregnancy and pre-eclampsia. QJM. 2002 Jun;95(6):359-62.Full text  Abstract

91. Cuenca-Martínez F, Zapardiel-Sánchez E, Carrasco-González E, et al. Assessing anxiety, depression and quality of life in patients with peripheral facial palsy: a systematic review. PeerJ. 2020;8:e10449.Full text  Abstract

92. Hotton M, Huggons E, Hamlet C, et al. The psychosocial impact of facial palsy: A systematic review. Br J Health Psychol. 2020 Sep;25(3):695-727.Full text  Abstract

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