Evaluation of vaginal bleeding

Workowski KA, Bachmann LH, Chan PA, et al. Sexually Transmitted Infections Treatment Guidelines, 2021. MMWR Recomm Rep. 2021 Jul 23;70(4):1-187.Full text  Abstract

National Institute for Health and Care Excellence. Ectopic pregnancy and miscarriage: diagnosis and initial management. Aug 2023 [internet publication].Full text

American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 193: tubal ectopic pregnancy. Mar 2018 [internet publication].Full text

1. Söderström HF, Carlsson A, Börjesson A, et al. Vaginal bleeding in prepubertal girls: etiology and clinical management. J Pediatr Adolesc Gynecol. 2016 Jun;29(3):280-5. Abstract

2. Lindner LE, Geerling S, Nettum JA, et al. Clinical characteristics of women with chlamydial cervicitis. J Reprod Med. 1988 Aug;33(8):684-90. Abstract

3. Shapley M, Jordan K, Croft PR. An epidemiological survey of symptoms of menstrual loss in the community. Br J Gen Pract. 2004 May;54(502):359-63.Full text  Abstract

4. Viikki M, Pukkala E, Hakama M. Bleeding symptoms and subsequent risk of gynecological and other cancers. Acta Obstet Gynecol Scand. 1998 May;77(5):564-9. Abstract

5. Cohen O, Schejter E, Agizim R, et al. Postcoital bleeding is a predictor for cervical dysplasia. PLoS One. 2019 May 23;14(5):e0217396.Full text  Abstract

6. Everett C. Incidence and outcome of bleeding before the 20th week of pregnancy: prospective study from general practice. BMJ. 1997 Jul 5;315(7099):32-4.Full text  Abstract

7. Hasan R, Baird DD, Herring AH, et al. Association between first-trimester vaginal bleeding and miscarriage. Obstet Gynecol. 2009 Oct;114(4):860-7.Full text  Abstract

8. Astrup K, Olivarius Nde F. Frequency of spontaneously occurring postmenopausal bleeding in the general population. Acta Obstet Gynecol Scand. 2004 Feb;83(2):203-7.Full text  Abstract

9. Puttemans P, Benagiano G, Gargett C, et al. Neonatal uterine bleeding as a biomarker for reproductive disorders during adolescence: a worldwide call for systematic registration by nurse midwife. J Matern Fetal Neonatal Med. 2017 Jun;30(12):1434-6.Full text  Abstract

10. Brosens I, Benagiano G. Is neonatal uterine bleeding involved in the pathogenesis of endometriosis as a source of stem cells? Fertil Steril. 2013 Sep;100(3):622-3.Full text

11. Stricker T, Navratil F, Sennhauser FH. Vaginal foreign bodies. J Paediatr Child Health. 2004 Apr;40(4):205-7. Abstract

12. Dwiggins M, Gomez-Lobo V. Current review of prepubertal vaginal bleeding. Curr Opin Obstet Gynecol. 2017 Oct;29(5):322-7. Abstract

13. Striegel AM, Myers JB, Sorensen MD, et al. Vaginal discharge and bleeding in girls younger than 6 years. J Urol. 2006 Dec;176(6 Pt 1):2632-5. Abstract

14. Tarney CM, Han J. Postcoital bleeding: a review on etiology, diagnosis, and management. Obstet Gynecol Int. 2014;2014:192087.Full text  Abstract

15. Workowski KA, Bachmann LH, Chan PA, et al. Sexually Transmitted Infections Treatment Guidelines, 2021. MMWR Recomm Rep. 2021 Jul 23;70(4):1-187.Full text  Abstract

16. Wilson JF. In the clinic. Vaginitis and cervicitis. Ann Intern Med. 2009 Sep 1;151(5):ITC3-1-15; quiz ITC3-16.

17. Taylor SN. Cervicitis of unknown etiology. Curr Infect Dis Rep. 2014 Jul;16(7):409. Abstract

18. World Health Organization. Cervical cancer. Mar 2024 [internet publication].Full text

19. International Collaboration of Epidemiological Studies of Cervical Cancer. Cervical carcinoma and sexual behavior: collaborative reanalysis of individual data on 15,461 women with cervical carcinoma and 29,164 women without cervical carcinoma from 21 epidemiological studies. Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1060-9.Full text  Abstract

20. Hessol NA, Whittemore H, Vittinghoff E, et al. Incidence of first and second primary cancers diagnosed among people with HIV, 1985-2013: a population-based, registry linkage study. Lancet HIV. 2018 Nov;5(11):e647-55. Abstract

21. International Collaboration of Epidemiological Studies of Cervical Cancer, Appleby P, Beral V, et al. Cervical cancer and hormonal contraceptives: collaborative reanalysis of individual data for 16,573 women with cervical cancer and 35,509 women without cervical cancer from 24 epidemiological studies. Lancet. 2007 Nov 10;370(9599):1609-21. Abstract

22. Shapley M, Jordan J, Croft PR. A systematic review of postcoital bleeding and risk of cervical cancer. Br J Gen Pract. 2006 Jun;56(527):453-60.Full text  Abstract

23. National Comprehensive Cancer Network. ​NCCN clinical practice guidelines in oncology: vaginal cancer [internet publication].Full text

24. Wiley DJ, Douglas J, Beutner K, et al. External genital warts: diagnosis, treatment, and prevention. Clin Infect Dis. 2002 Oct 15;35(Suppl 2):S210-24.Full text  Abstract

25. National Institute for Health and Care Excellence. Ectopic pregnancy and miscarriage: diagnosis and initial management. Aug 2023 [internet publication].Full text

26. Panelli DM, Phillips CH, Brady PC. Incidence, diagnosis and management of tubal and nontubal ectopic pregnancies: a review. Fertil Res Pract. 2015 Oct 15;1:15.Full text  Abstract

27. Furlong LA. Ectopic pregnancy risk when contraception fails. A review. J Reprod Med. 2002 Nov;47(11):881-5. Abstract

28. Wilcox AJ, Weinberg CR, O'Connor JF, et al. Incidence of early loss of pregnancy. N Engl J Med. 1988 Jul 28;319(4):189-94. Abstract

29. Expert Panel on GYN and OB Imaging; Shipp TD, Poder L, et al. ACR appropriateness criteria® second and third trimester vaginal bleeding. J Am Coll Radiol. 2020 Nov;17(11S):S497-504.Full text  Abstract

30. Ananth CV, Keyes KM, Hamilton A, et al. An international contrast of rates of placental abruption: an age-period-cohort analysis. PLoS One. 2015 May 27;10(5):e0125246.Full text  Abstract

31. El-Kady D, Gilbert WM, Anderson J, et al. Trauma during pregnancy: an analysis of maternal and fetal outcomes in a large population. Am J Obstet Gynecol. 2004 Jun;190(6):1661-8. Abstract

32. Ananth CV, Smulian JC, Vintzileos AM. Incidence of placental abruption in relation to cigarette smoking and hypertensive disorders during pregnancy: a meta-analysis of observational studies. Obstet Gynecol. 1999 Apr;93(4):622-8. Abstract

33. Addis A, Moretti ME, Ahmed Syed F, et al. Fetal effects of cocaine: an updated meta-analysis. Reprod Toxicol. 2001 Jul-Aug;15(4):341-69. Abstract

34. Rasmussen S, Irgens LM, Dalaker K. Outcome of pregnancies subsequent to placental abruption: a risk assessment. Acta Obstet Gynecol Scand. 2000 Jun;79(6):496-501. Abstract

35. Silver RM, Branch DW. Placenta accreta spectrum. N Engl J Med. 2018 Apr 19;378(16):1529-36.

36. Conde-Agudelo A, Rosas-Bermudez A, Kafury-Goeta AC. Effects of birth spacing on maternal health: a systematic review. Am J Obstet Gynecol. 2007;196:297-308. Abstract

37. American College of Obstetricians and Gynecologists' Committee on Practice Bulletins-Gynecology. ACOG Committee Opinion No. 743: low-dose aspirin use during pregnancy. Obstet Gynecol. 2018 Jul;132(1):e44-52.Full text  Abstract

38. Roberge S, Bujold E, Nicolaides KH. Meta-analysis on the effect of aspirin use for prevention of preeclampsia on placental abruption and antepartum hemorrhage. Am J Obstet Gynecol. 2018 May;218(5):483-9.Full text  Abstract

39. Souter V, Painter I, Sitcov K, et al. Propensity score analysis of low-dose aspirin and bleeding complications in pregnancy. Ultrasound Obstet Gynecol. 2024 Jan;63(1):81-7.Full text  Abstract

40. Hastie R, Tong S, Wikström AK, et al. Aspirin use during pregnancy and the risk of bleeding complications: a Swedish population-based cohort study. Am J Obstet Gynecol. 2021 Jan;224(1):95.e1-95. Abstract

41. Yip KC, Luo Z, Huang X, et al. The role of aspirin dose and initiation time in the prevention of preeclampsia and corresponding complications: a meta-analysis of RCTs. Arch Gynecol Obstet. 2022 Jun;305(6):1465-79. Abstract

42. Henderson JT, Vesco KK, Senger CA, et al. Aspirin use to prevent preeclampsia and related morbidity and mortality: updated evidence report and systematic review for the US Preventive Services Task Force. JAMA. 2021 Sep 28;326(12):1192-206.Full text  Abstract

43. Clarke MA, Long BJ, Del Mar Morillo A, et al. Association of endometrial cancer risk with postmenopausal bleeding in women: a systematic review and meta-analysis. JAMA Intern Med. 2018 Sep 1;178(9):1210-22.Full text  Abstract

44. Bankhead CR, Collins C, Stokes-Lampard H, et al. Identifying symptoms of ovarian cancer: a qualitative and quantitative study. BJOG. 2008 Jul;115(8):1008-14.Full text  Abstract

45. Practice Committee of American Society for Reproductive Medicine. Medical treatment of ectopic pregnancy: a committee opinion. Fertil Steril. 2013 Sep;100(3):638-44.Full text  Abstract

46. American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 193: tubal ectopic pregnancy. Mar 2018 [internet publication].Full text

47. Elson CJ, Salim R, Potdar N, et al; Royal College of Obstetricians and Gynaecologists. Diagnosis and management of ectopic pregnancy: green-top guideline no. 21. BJOG. 2016 Dec;123(13):e15-e55.Full text

48. Casanovas M, Kramer T, Clarke V, et al. Somatic symptoms following sexual assault in adolescents: a prospective longitudinal study. Psychol Health Med. 2022 Mar;27(3):546-58.Full text  Abstract

49. Kugler BB, Bloom M, Kaercher LB, et al. Somatic symptoms in traumatized children and adolescents. Child Psychiatry Hum Dev. 2012 Oct;43(5):661-73. Abstract

50. Heger A, Ticson L, Velasquez O, et al. Children referred for possible sexual abuse: medical findings in 2384 children. Child Abuse Negl. 2002 Jun;26(6-7):645-59. Abstract

51. Palusci VJ, Cox EO, Shatz EM, et al. Urgent medical assessment after child sexual abuse. Child Abuse Negl. 2006 Apr;30(4):367-80. Abstract

52. Orbach Y, Hershkowitz I, Lamb ME, et al. Assessing the value of structured protocols for forensic interviews of alleged child abuse victims. Child Abuse Negl. 2000 Jun;24(6):733-52. Abstract

53. Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girls. Arch Dis Child. 1969 Jun;44(235):291-303.Full text

54. Spitzer RF, Kives S, Caccia N, et al. Retrospective review of unintentional female genital trauma at a pediatric referral center. Pediatr Emerg Care. 2008 Dec;24(12):831-5. Abstract

55. Brander EPA, McQuillan SK. Prepubertal vulvovaginitis. CMAJ. 2018 Jul 3;190(26):E800.Full text

56. Brook G, Church H, Evans C, et al. 2019 UK National guideline for consultations requiring sexual history taking: Clinical Effectiveness Group British Association for Sexual Health and HIV. Int J STD AIDS. 2020 Sep;31(10):920-38. Abstract

57. Evans D, Goldstein S, Loewy A, et al. No. 385-Indications for pelvic examination. J Obstet Gynaecol Can. 2019 Aug;41(8):1221-34. Abstract

58. Crochet JR, Bastian LA, Chireau MV. Does this woman have an ectopic pregnancy?: the rational clinical examination systematic review. JAMA. 2013 Apr 24;309(16):1722-9. Abstract

59. Cohen PA, Jhingran A, Oaknin A, et al. Cervical cancer. Lancet. 2019 Jan 12;393(10167):169-82. Abstract

60. Royal College of Obstetricians and Gynaecologists. Antepartum haemorrhage (Green-top guideline No. 63). 5 Dec 2011 [internet publication].Full text

61. Wølner-Hanssen P, Krieger JN, Stevens CE, et al. Clinical manifestations of vaginal trichomoniasis. JAMA. 1989 Jan 27;261(4):571-6. Abstract

62. Castelo-Branco C, Cancelo MJ, Villero J, et al. Management of post-menopausal vaginal atrophy and atrophic vaginitis. Maturitas. 2005 Nov 15;52 (1 Suppl):S46-52. Abstract

63. Oyelese Y, Ananth CV. Placental abruption. Obstet Gynecol. 2006 Oct;108(4):1005-16. Abstract

64. Expert Panel on Women’s Imaging; Brown DL, Packard A, et al. ACR Appropriateness Criteria® first trimester vaginal bleeding. J Am Coll Radiol. 2018 May;15(5S):S69-77.Full text  Abstract

65. Expert Panel on GYN and OB Imaging; Patel-Lippmann KK, Wasnik AP, et al. ACR appropriateness criteria® clinically suspected adnexal mass, no acute symptoms: 2023 update. J Am Coll Radiol. 2024 Jun;21(6S):S79-99.Full text  Abstract

66. ACOG Committee Opinion No. 734: The role of transvaginal ultrasonography in evaluating the endometrium of women with postmenopausal bleeding. Obstet Gynecol. 2018 May;131(5):e124-9.Full text  Abstract

67. Oaknin A, Bosse TJ, Creutzberg CL, et al. Endometrial cancer: ESMO clinical practice guideline for diagnosis, treatment and follow-up. Ann Oncol. 2022 Sep;33(9):860-77.Full text

68. Yudin MH, Hillier SL, Wiesenfeld HC, et al. Vaginal polymorphonuclear leukocytes and bacterial vaginosis as markers for histologic endometritis among women without symptoms of pelvic inflammatory disease. Am J Obstet Gynecol. 2003 Feb;188(2):318-23. Abstract

69. Coeman D, Van Belle Y, Vanderick G, et al. Hysteroscopic findings in patients with a cervical polyp. Am J Obstet Gynecol. 1993 Dec;169(6):1563-5. Abstract

70. Einhorn N, Sjövall K, Knapp RC, et al. Prospective evaluation of serum CA 125 levels for early detection of ovarian cancer. Obstet Gynecol. 1992 Jul;80(1):14-8. Abstract

71. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: ovarian cancer/fallopian tube cancer/primary peritoneal cancer [internet publication].Full text

72. O'Brien KL, Shainker SA, Lockhart EL. Transfusion management of obstetric hemorrhage. Transfus Med Rev. 2018 Oct;32(4):249-55. Abstract

73. Glantz C, Purnell L. Clinical utility of sonography in the diagnosis and treatment of placental abruption. J Ultrasound Med. 2002 Aug;21(8):837-40. Abstract

74. Marrazzo JM, Martin DH. Management of women with cervicitis. Clin Infect Dis. 2007 Apr 1;44 Suppl 3:S102-10. Abstract

75. Nugent RP, Krohn MA, Hillier SL. Reliability of diagnosing bacterial vaginosis is improved by a standardized method of Gram stain interpretation. J Clin Microbiol. 1991 Feb;29(2):297-301.Full text  Abstract

76. British Society for Paediatric and Adolescent Gynaecology. Genital trauma in girls. Jun 2017 [internet publication].Full text