FMF is certainly the most frequent among hereditary recurrent inflammatory disorders. This disease affects mainly populations of Mediterranean descent: Arabs from the East as well as from the West, Armenians, Turks, non-Ashkenazi and other Jews, Druzes, Lebanese, Italians, and Greeks. Some patients were also reported in Japan. Among non-Ashkenazi Jews and Turks, the frequency of heterozygotes in the general population may be greater than 1 in 5 people. High prevalence explains the pseudo-dominant mode of inheritance observed in these populations. Prevalence is extremely rare among people of non-Mediterranean descent. There are also reports of occurrence in Melungeon populations (tri-racial mix of European, sub-Saharan African, American Indian, and Mediterranean origins living mostly in the Appalachian region) within the US.
BMJ Best Practice is an evidence-based point of care tool for healthcare practitioners.
To continue reading and access all of BMJ Best Practice's pages you'll need to log in or start a free trial.
You can access through your institution if your hospital, university, trust or other institution provides access to BMJ Best Practice through either OpenAthens or Shibboleth.
Use of this content is subject to our disclaimer