Alcohol-related liver disease

References

Key articles

Heimbach J, Kulik LM, Finn R, et al. AASLD guidelines for the treatment of hepatocellular carcinoma. Hepatology. 2018 Jan;67(1):358-80.Full text  Abstract

Naveau S, Giraud V, Borotto E, et al. Excess weight risk factor for alcoholic liver disease. Hepatology. 1997 Jan;25(1):108-11.Full text  Abstract

Reference articles

1. Axley PD, Richardson CT, Singal AK. Epidemiology of alcohol consumption and societal burden of alcoholism and alcoholic liver disease. Clin Liver Dis. 2019 Feb;23(1):39-50. Abstract

2. World Health Organization. Fact sheet: alcohol. May 2022 [internet publication].Full text

3. Julien J, Ayer T, Bethea ED, et al. Projected prevalence and mortality associated with alcohol-related liver disease in the USA, 2019-40: a modelling study. Lancet Public Health. 2020 Jun;5(6):e316-23.Full text  Abstract

4. Substance Abuse and Mental Health Services Administration (SAMHSA). Results from the 2018 national survey on drug use and health. 2019 [internet publication].Full text

5. National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health. Alcohol facts and statistics. Jun 2021 [internet publication].Full text

6. Centers for Disease Control and Prevention. National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP): excessive alcohol use. Jul 2022 [internet publication].Full text

7. Centers for Disease Control and Prevention. Alcohol and public health: alcohol-related disease impact (ARDI). Sept 2020 [internet publication].Full text

8. Grucza RA, Sher KJ, Kerr WC, et al. Trends in adult alcohol use and binge drinking in the early 21st-century United States: a meta-analysis of 6 national survey series. Alcohol Clin Exp Res. 2018 Oct;42(10):1939-50. Abstract

9. Dang K, Hirode G, Singal AK, et al. Alcoholic liver disease epidemiology in the United States: a retrospective analysis of 3 US databases. Am J Gastroenterol. 2020 Jan;115(1):96-104. Abstract

10. Public Health England. Official statistics: Liver disease profiles: short statistical commentary, October 2018. Oct 2018 [internet publication].Full text

11. Office for Health Improvement & Disparities. Liver disease profiles, July 2023 update. Jul 2023 [internet publication].Full text

12. Office for Health Improvement & Disparities. Liver disease: applying all our health​. May 2022 [internet publication].Full text

13. Xu H, Xiao P, Zhang F, et al. Epidemic characteristics of alcohol-related liver disease in Asia from 2000 to 2020: a systematic review and meta-analysis. Liver Int. 2022 Aug;42(9):1991-98.Full text  Abstract

14. Rehm J, Taylor B, Mohapatra S, et al. Alcohol as a risk factor for liver cirrhosis: a systematic review and meta-analysis. Drug Alcohol Rev. 2010 Jul;29(4):437-45. Abstract

15. Singal AK, Bataller R, Ahn J, et al. ACG clinical guideline: alcoholic liver disease. Am J Gastroenterol. 2018 Feb;113(2):175-94.Full text  Abstract

16. Gao B, Bataller R. Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology. 2011 Nov;141(5):1572-85.Full text  Abstract

17. Mueller S, Millonig G, Seitz HK. Alcoholic liver disease and hepatitis C: a frequently underestimated combination. World J Gastroenterol. 2009 Jul 28;15(28):3462-71.Full text  Abstract

18. Raynard B, Balian A, Fallik D, et al. Risk factors of fibrosis in alcohol-induced liver disease. Hepatology. 2002 Mar;35(3):635-8.Full text  Abstract

19. Hart CL, Morrison DS, Batty GD, et al. Effect of body mass index and alcohol consumption on liver disease: analysis of data from two prospective cohort studies. BMJ. 2010 Mar 11;340:c1240.Full text  Abstract

20. Klatsky AL, Armstrong MA. Alcohol, smoking, coffee, and cirrhosis. Am J Epidemiol. 1992 Nov 15;136(10):1248-57. Abstract

21. Morgan TR, Mandayam S, Jamal MM. Alcohol and hepatocellular carcinoma. Gastroenterology. 2004 Nov;127(5 Suppl 1):S87-96. Abstract

22. Zhao YY, Xiao M, Zhang CL, et al. Associations between the tumor necrosis factor-α gene and interleukin-10 gene polymorphisms and risk of alcoholic liver disease: A meta-analysis. Clin Res Hepatol Gastroenterol. 2016 Sep;40(4):428-39. Abstract

23. Wang X, Yan Z, Ye Q. Interleukin-6 gene polymorphisms and susceptibility to liver diseases: A meta-analysis. Medicine (Baltimore). 2019 Dec;98(50):e18408.Full text  Abstract

24. Salameh H, Raff E, Erwin A, et al. PNPLA3 gene polymorphism is associated with predisposition to and severity of alcoholic liver disease. Am J Gastroenterol. 2015 Jun;110(6):846-56. Abstract

25. Stickel F, Datz C, Hampe J, et al. Pathophysiology and management of alcoholic liver disease: update 2016. Gut Liver. 2017 Mar 15;11(2):173-88.Full text  Abstract

26. Gramenzi A, Caputo F, Biselli M, et al. Review article: alcoholic liver disease - pathophysiological aspects and risk factors. Aliment Pharmacol Ther. 2006 Oct 15;24(8):1151-61.Full text  Abstract

27. Rao R. Endotoxemia and gut barrier dysfunction in alcoholic liver disease. Hepatology. 2009 Aug;50(2):638-44.Full text  Abstract

28. Li Y, Zhou J. Roles of silent information regulator 1-serine/arginine-rich splicing factor 10-lipin 1 axis in the pathogenesis of alcohol fatty liver disease. Exp Biol Med (Maywood). 2017 Jun;242(11):1117-25. Abstract

29. Zhang R, Tang Z, Xu W, et al. Risk factors and protective factors for alcohol-related liver disease: a systematic review and meta-analysis. Alcohol Clin Exp Res. 2022 Dec;46(12):2128-36. Abstract

30. Singal AK, Mathurin P. Diagnosis and treatment of alcohol-associated liver disease: a review. JAMA. 2021 Jul 13;326(2):165-76. Abstract

31. Mendenhall CL, Seeff L, Diehl AM, et al. Antibodies to hepatitis B virus and hepatitis C virus in alcoholic hepatitis and cirrhosis: their prevalence and clinical relevance. Hepatology. 1991 Oct;14(4 Pt 1):581-9. Abstract

32. Caldwell SH, Li X, Rourk RM, et al. Hepatitis C infection by polymerase chain reaction in alcoholics: false-positive ELISA results and the influence of infection on a clinical prognostic score. Am J Gastroenterol. 1993 Jul;88(7):1016-21. Abstract

33. Loft S, Olesen KL, Dossing M. Increased susceptibility to liver disease in relation to alcohol consumption in women. Scand J Gastroenterol. 1987 Dec;22(10):1251-6. Abstract

34. National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health. Women and alcohol. Jun 2019 [internet publication].Full text

35. Seitz HK, Stickel F. Alcoholic liver disease in the elderly. Clin Geriatr Med. 2007 Nov;23(4):905-21. Abstract

36. National Institute on Alcohol Abuse and Alcoholism. Surveillance report 118: liver cirrhosis mortality in the United States: national, state, and regional trends, 2000-2019. Feb 2022 [internet publication].Full text

37. Kochanek KD, Murphy SL, Xu J, et al. Deaths: final data for 2017. Natl Vital Stat Rep. 2019 Jun;68(9):1-77.Full text  Abstract

38. Crabb DW, Im GY, Szabo G, et al. Diagnosis and treatment of alcohol-associated liver diseases: 2019 practice guidance from the American Association for the Study of Liver Diseases. Hepatology. 2020 Jan;71(1):306-33.Full text  Abstract

39. Buchsbaum DG, Buchanan RG, Centor RM, et al. Screening for alcohol abuse using CAGE scores and likelihood ratios. Ann Intern Med. 1991 Nov 15;115(10):774-7. Abstract

40. Girela E, Villanueva E, Hernandez-Cueto C, et al. Comparison of the CAGE questionnaire versus some biochemical markers in the diagnosis of alcoholism. Alcohol Alcohol. 1994 May;29(3):337-43. Abstract

41. Aalto M, Alho H, Halme JT, et al. AUDIT and its abbreviated versions in detecting heavy and binge drinking in a general population survey. Drug Alcohol Depend. 2009 Jul 1;103(1-2):25-9. Abstract

42. European Association for the Study of the Liver. EASL clinical practice guidelines: management of alcohol-related liver disease. J Hepatol. 2018 Jul;69(1):154-81.Full text  Abstract

43. Senousy BE, Draganov PV. Evaluation and management of patients with refractory ascites. World J Gastroenterol. 2009 Jan 7;15(1):67-80.Full text  Abstract

44. Ahmed Z, Ahmed U, Walayat S, et al. Liver function tests in identifying patients with liver disease. Clin Exp Gastroenterol. 2018;11:301-7.Full text  Abstract

45. Cohen JA, Kaplan MM. The SGOT/SGPT ratio - an indicator of alcoholic liver disease. Dig Dis Sci. 1979 Nov;24(11):835-8. Abstract

46. Kwo PY, Cohen SM, Lim JK. ACG Clinical Guideline: evaluation of abnormal liver chemistries. Am J Gastroenterol. 2017 Jan;112(1):18-35.Full text  Abstract

47. Koperdanova M, Cullis JO. Interpreting raised serum ferritin levels. BMJ. 2015 Aug 3;351:h3692. Abstract

48. Jarvis M, Williams J, Hurford M, et al. Appropriate use of drug testing in clinical addiction medicine. J Addict Med. 2017 May/Jun;11(3):163-73.Full text  Abstract

49. Andresen-Streichert H, Beres Y, Weinmann W, et al. Improved detection of alcohol consumption using the novel marker phosphatidylethanol in the transplant setting: results of a prospective study. Transpl Int. 2017 Jun;30(6):611-20.Full text  Abstract

50. Yersin B, Nicolet JF, Dercrey H, et al. Screening for excessive alcohol drinking: comparative value of carbohydrate-deficient transferrin, gamma-glutamyltransferase, and mean corpuscular volume. Arch Intern Med. 1995 Sep 25;155(17):1907-11. Abstract

51. Stauber RE, Stepan V, Trauner M, et al. Evaluation of carbohydrate-deficient transferrin for detection of alcohol abuse in patients with liver dysfunction. Alcohol Alcohol. 1995 Mar;30(2):171-6. Abstract

52. Arnts J, Vanlerberghe BTK, Roozen S, et al. Diagnostic accuracy of biomarkers of alcohol use in patients with liver disease: a systematic review. Alcohol Clin Exp Res. 2021 Jan;45(1):25-37.Full text  Abstract

53. Lumeng L. New diagnostic markers of alcohol abuse. Hepatology. 1986 Jul-Aug;6(4):742-5. Abstract

54. Moreno C, Mueller S, Szabo G. Non-invasive diagnosis and biomarkers in alcohol-related liver disease. J Hepatol. 2019 Feb;70(2):273-83.Full text  Abstract

55. Hinkson A, Lally H, Gibson H, et al. Meta-analysis: enhanced liver fibrosis test to identify hepatic fibrosis in chronic liver diseases. Aliment Pharmacol Ther. 2023 Apr;57(7):750-62. Abstract

56. Pavlov CS, Casazza G, Nikolova D, et al. Transient elastography for diagnosis of stages of hepatic fibrosis and cirrhosis in people with alcoholic liver disease. Cochrane Database Syst Rev. 2015 Jan 22;1:CD010542.Full text  Abstract

57. Louvet A, Trabut JB, Moreno C, et al. Management of alcohol-related liver disease: the French Association for the Study of the Liver and the French Alcohol Society clinical guidelines. Liver Int. 2022 Jun;42(6):1330-43.Full text  Abstract

58. Giuffrè M, Campigotto M, Colombo A, et al. The role of elastography in alcoholic liver disease: fibrosis staging and confounding factors, a review of the current literature. Minerva Gastroenterol (Torino). 2021 Jun;67(2):112-21. Abstract

59. European Association for the Study of the Liver. EASL clinical practice guidelines on non-invasive tests for evaluation of liver disease severity and prognosis - 2021 update. J Hepatol. 2021 Sep;75(3):659-89.Full text  Abstract

60. Van Ness MM, Diehl AM. Is liver biopsy useful in the evaluation of patients with chronically elevated liver enzymes? Ann Intern Med. 1989 Sep 15;111(6):473-8. Abstract

61. Mathurin P, Duchatelle V, Ramond MJ, et al. Survival and prognostic factors in patients with severe alcoholic hepatitis treated with prednisolone. Gastroenterology. 1996 Jun;110(6):1847-53. Abstract

62. Tsiaousi ET, Hatzitolios AI, Trygonis SK, et al. Malnutrition in end stage liver disease: recommendations and nutritional support. J Gastroenterol Hepatol. 2008 Apr;23(4):527-33.Full text  Abstract

63. Sinclair M, Gow PJ, Grossmann M, et al. Review article: sarcopenia in cirrhosis--aetiology, implications and potential therapeutic interventions. Aliment Pharmacol Ther. 2016 Apr;43(7):765-77.Full text  Abstract

64. Kośnik A, Wójcicki M. Fatigue in chronic liver disease patients: prevalence, pathophysiology, and management. Prz Gastroenterol. 2022;17(1):21-7.Full text  Abstract

65. Shawcross DL, Dunk AA, Jalan R, et al. How to diagnose and manage hepatic encephalopathy: a consensus statement on roles and responsibilities beyond the liver specialist. Eur J Gastroenterol Hepatol. 2016 Feb;28(2):146-52.Full text  Abstract

66. Sansone A, Romanelli F, Sansone M, et al. Gynecomastia and hormones. Endocrine. 2017 Jan;55(1):37-44. Abstract

67. Bell H, Tallaksen CM, Try K, et al. Carbohydrate-deficient transferrin and other markers of high alcohol consumption: a study of 502 patients admitted consecutively to a medical department. Alcohol Clin Exp Res. 1994 Oct;18(5):1103-8. Abstract

68. Prati D, Taioli E, Zanella A, et al. Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med. 2002 Jul 2;137(1):1-10. Abstract

69. Marsano LS, Mendez C, Hill D, et al. Diagnosis and treatment of alcoholic liver disease and its complications. Alcohol Res Health. 2003;27(3):247-56.Full text  Abstract

70. Singal A, Volk ML, Waljee A, et al. Meta-analysis: surveillance with ultrasound for early-stage hepatocellular carcinoma in patients with cirrhosis. Aliment Pharmacol Ther. 2009 Jul;30(1):37-47. Abstract

71. Stewart SH, Koch DG, Willner IR, et al. Validation of blood phosphatidylethanol as an alcohol consumption biomarker in patients with chronic liver disease. Alcohol Clin Exp Res. 2014 Jun;38(6):1706-11. Abstract

72. Vos AD, Troyer RD, Stove C, et al. Biomarkers of alcohol misuse. In: Preedy VR, ed. Neuroscience of alcohol. Cambridge, MA: Academic Press; 2019:557-65.

73. US Preventive Services Task Force., Curry SJ, Krist AH, et al. Screening and behavioral counseling interventions to reduce unhealthy alcohol use in adolescents and adults: US Preventive Services Task Force recommendation statement. JAMA. 2018 Nov 13;320(18):1899-1909.Full text  Abstract

74. Hoeksema HL, de Bock GH. The value of laboratory tests for the screening and recognition of alcohol abuse in primary care patients. J Fam Pract. 1993 Sep;37(3):268-76. Abstract

75. Thompson Coon J, Rogers G, Hewson P, et al. Surveillance of cirrhosis for hepatocellular carcinoma: systematic review and economic analysis. Health Technol Assess. 2007 Sep;11(34):1-206.Full text  Abstract

76. Heimbach J, Kulik LM, Finn R, et al. AASLD guidelines for the treatment of hepatocellular carcinoma. Hepatology. 2018 Jan;67(1):358-80.Full text  Abstract

77. Colli A, Fraquelli M, Casazza G, et al. Accuracy of ultrasonography, spiral CT, magnetic resonance, and alpha-fetoprotein in diagnosing hepatocellular carcinoma: a systematic review. Am J Gastroenterol. 2006 Mar;101(3):513-23. Abstract

78. American College of Radiology. ACR Appropriateness Criteria®: abnormal liver function tests. 2023 [internet publication].Full text

79. Storm AC, Fishman DS, Buxbaum JL, et al. American Society for Gastrointestinal Endoscopy guideline on informed consent for GI endoscopic procedures. Gastrointest Endosc. 2022 Feb;95(2):207-15. Abstract

80. Biggins SW, Angeli P, Garcia-Tsao G, et al. Diagnosis, evaluation, and management of ascites, spontaneous bacterial peritonitis and hepatorenal syndrome: 2021 practice guidance by the American Association for the Study of Liver Diseases. Hepatology. 2021 Aug;74(2):1014-48.Full text  Abstract

81. Arab JP, Roblero JP, Altamirano J, et al. Alcohol-related liver disease: clinical practice guidelines by the Latin American Association for the Study of the Liver (ALEH). Ann Hepatol. 2019 May - Jun;18(3):518-35.Full text  Abstract

82. Berry PA, Thomson SJ, Rahman TM, et al. Review article: towards a considered and ethical approach to organ support in critically-ill patients with cirrhosis. Aliment Pharmacol Ther. 2013 Jan;37(2):174-82.Full text  Abstract

83. Powell WJ Jr, Klatskin G. Duration of survival in patients with Laennec's cirrhosis: influence of alcohol withdrawal, and possible effects of recent changes in general management of the disease. Am J Med. 1968 Mar;44(3):406-20. Abstract

84. Veldt BJ, Laine F, Guillygomarc'h A, et al. Indication of liver transplantation in severe alcoholic liver cirrhosis: quantitative evaluation and optimal timing. J Hepatol. 2002 Jan;36(1):93-8. Abstract

85. Altamirano J, López-Pelayo H, Michelena J, et al. Alcohol abstinence in patients surviving an episode of alcoholic hepatitis: prediction and impact on long-term survival. Hepatology. 2017 Dec;66(6):1842-53.Full text  Abstract

86. Naveau S, Giraud V, Borotto E, et al. Excess weight risk factor for alcoholic liver disease. Hepatology. 1997 Jan;25(1):108-11.Full text  Abstract

87. Umemura T, Ichijo T, Matsumoto A, et al. Severe hepatic injury caused by orlistat. Am J Med. 2006 Aug;119(8):e7. Abstract

88. Sall D, Wang J, Rashkin M, et al. Orlistat-induced fulminant hepatic failure. Clin Obes. 2014 Dec;4(6):342-7. Abstract

89. Wakim-Fleming J, Mullen KD. Long-term management of alcoholic liver disease. Clin Liver Dis. 2005 Feb;9(1):135-49. Abstract

90. McCullough AJ, Tavill AS. Disordered energy and protein metabolism in liver disease. Semin Liver Dis. 1991 Nov;11(4):265-77. Abstract

91. McCullough AJ, Bugianesi E. Protein-calorie malnutrition and the etiology of cirrhosis. Am J Gastroenterol. 1997 May;92(5):734-8. Abstract

92. Vasco M, Paolillo R, Schiano C, et al. Compromised nutritional status in patients with end-stage liver disease: role of gut microbiota. Hepatobiliary Pancreat Dis Int. 2018 Aug;17(4):290-300. Abstract

93. Swart GR, Zillikens MC, van Vuure JK, et al. Effect of a late evening meal on nitrogen balance in patients with cirrhosis of the liver. BMJ. 1989 Nov 11;299(6709):1202-3.Full text  Abstract

94. Verboeket-Van De Venne WP, Westerterp KR, Van Hoek B, et al. Habitual pattern of food intake in patients with liver disease. Clin Nutr. 1993 Oct;12(5):293-7. Abstract

95. Stickel F, Hoehn B, Schuppan D, et al. Review article: nutritional therapy in alcoholic liver disease. Aliment Pharmacol Ther. 2003 Aug 15;18(4):357-73.Full text  Abstract

96. Muto Y, Sato S, Watanabe A, et al. Effects of oral branched-chain amino acid granules on event-free survival in patients with liver cirrhosis. Clin Gastroenterol Hepatol. 2005 Jul;3(7):705-13.Full text  Abstract

97. Moreno C, Langlet P, Hittelet A, et al. Enteral nutrition with or without N-acetylcysteine in the treatment of severe acute alcoholic hepatitis: a randomized multicenter controlled trial. J Hepatol. 2010 Dec;53(6):1117-22. Abstract

98. Bhavsar-Burke I, Jansson-Knodell CL, Gilmore AC, et al. Review article: the role of nutrition in alcohol-associated liver disease. Aliment Pharmacol Ther. 2021 Jun;53(12):1268-76. Abstract

99. Antar R, Wong P, Ghali P. A meta-analysis of nutritional supplementation for management of hospitalized alcoholic hepatitis. Can J Gastroenterol. 2012 Jul;26(7):463-7. Abstract

100. Gluud LL, Dam G, Les I, et al. Branched-chain amino acids for people with hepatic encephalopathy. Cochrane Database Syst Rev. 2017 May 18;(5):CD001939.Full text  Abstract

101. Koretz RL. The evidence for the use of nutritional support in liver disease. Curr Opin Gastroenterol. 2014 Mar;30(2):208-14. Abstract

102. Ney M, Vandermeer B, van Zanten SJ, et al. Meta-analysis: oral or enteral nutritional supplementation in cirrhosis. Aliment Pharmacol Ther. 2013 Apr;37(7):672-9.Full text  Abstract

103. McCullough AJ, O'Connor JF. Alcoholic liver disease: proposed recommendations for the American College of Gastroenterology. Am J Gastroenterol. 1998 Nov;93(11):2022-36. Abstract

104. Barve A, Khan R, Marsano L, et al. Treatment of alcoholic liver disease. Ann Hepatol. 2008 Jan-Mar;7(1):5-15. Abstract

105. Shah ND, Barritt AS 4th. Nutrition as therapy in liver disease. Clin Ther. 2022 May;44(5):682-96.Full text  Abstract

106. Louvet A, Thursz MR, Kim DJ, et al. Corticosteroids reduce risk of death within 28 days for patients with severe alcoholic hepatitis, compared with pentoxifylline or placebo: a meta-analysis of individual data from controlled trials. Gastroenterology. 2018 Aug;155(2):458-68. Abstract

107. Pavlov CS, Varganova DL, Casazza G, et al. Glucocorticosteroids for people with alcoholic hepatitis. Cochrane Database Syst Rev. 2019 Apr 9;(4):CD001511.Full text  Abstract

108. Carithers RL Jr, Herlong HF, Diehl AM, et al. Methylprednisolone therapy in patients with severe alcoholic hepatitis: a randomized multicenter trial. Ann Intern Med. 1989 May 1;110(9):685-90. Abstract

109. Mathurin P, O'Grady J, Carithers RL, et al. Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis: meta-analysis of individual patient data. Gut. 2011 Feb;60(2):255-60. Abstract

110. Mathurin P, Abdelnour M, Ramond MJ, et al. Early change in bilirubin levels is an important prognostic factor in severe alcoholic hepatitis treated with prednisolone. Hepatology. 2003 Dec;38(6):1363-9.Full text  Abstract

111. Louvet A, Naveau S, Abdelnour M, et al. The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids. Hepatology. 2007 Jun;45(6):1348-54.Full text  Abstract

112. Imperiale TF, McCullough AJ. Do corticosteroids reduce mortality from alcoholic hepatitis? A meta-analysis of the randomized trials. Ann Intern Med. 1990 Aug 15;113(4):299-307. Abstract

113. Mathurin P. Is alcoholic hepatitis an indication for transplantation? Current management and outcomes. Liver Transpl. 2005 Nov;(11 suppl 2):S21-4.Full text  Abstract

114. Hmoud BS, Patel K, Bataller R, et al. Corticosteroids and occurrence of and mortality from infections in severe alcoholic hepatitis: a meta-analysis of randomized trials. Liver Int. 2016 May;36(5):721-8. Abstract

115. Tilg H, Jalan R, Kaser A, et al. Anti-tumor necrosis factor-alpha monoclonal antibody therapy in severe alcoholic hepatitis. J Hepatol. 2003 Apr;38(4):419-25. Abstract

116. Naveau S, Chollet-Martin S, Dharancy S, et al. A double-blind randomized controlled trial of infliximab associated with prednisolone in acute alcoholic hepatitis. Hepatology. 2004 May;39(5):1390-7.Full text  Abstract

117. European Association for the Study of the Liver. EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis. J Hepatol. 2010 Sep;53(3):397-417.Full text  Abstract

118. Aithal GP, Palaniyappan N, China L, et al. Guidelines on the management of ascites in cirrhosis. Gut. 2021 Jan;70(1):9-29.Full text  Abstract

119. Biggins SW, Angeli P, Garcia-Tsao G, et al. Diagnosis, evaluation, and management of ascites, spontaneous bacterial peritonitis and hepatorenal syndrome: 2021 practice guidance by the American Association for the Study of Liver Diseases. Hepatology. 2021;74(2):1014-48.Full text  Abstract

120. European Association for the Study of the Liver. EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis. J Hepatol. 2010;53(3):397-417.Full text  Abstract

121. Bernardi M, Caraceni P, Navickis RJ, et al. Albumin infusion in patients undergoing large-volume paracentesis: a meta-analysis of randomized trials. Hepatology. 2012 Apr;55(4):1172-81.Full text  Abstract

122. Aithal GP, Palaniyappan N, China L, et al. Guidelines on the management of ascites in cirrhosis. Gut. 2021 Jan;70(1):9-29.Full text  Abstract

123. Rimola A, Garcia-Tsao G, Navasa M, et al. Diagnosis, treatment and prophylaxis of spontaneous bacterial peritonitis: a consensus document. J Hepatol. 2000 Jan;32(1):142-53. Abstract

124. Loomba R, Wesley R, Bain A, et al. Role of fluoroquinolones in the primary prophylaxis of spontaneous bacterial peritonitis: meta-analysis. Clin Gastroenterol Hepatol. 2009 Apr;7(4):487-93. Abstract

125. Oshita M, Hayashi N, Kasahara A, et al. Increased serum hepatitis C virus RNA levels among alcoholic patients with chronic hepatitis C. Hepatology. 1994 Nov;20(5):1115-20. Abstract

126. Ohnishi K, Matsuo S, Matsutani K, et al. Interferon therapy for chronic hepatitis C in habitual drinkers: comparison with chronic hepatitis C in infrequent drinkers. Am J Gastroenterol. 1996 Jul;91(7):1374-9. Abstract

127. Keeffe EB. Comorbidities of alcoholic liver disease that affect outcome of orthotopic liver transplantation. Liver Transpl Surg. 1997 May;3(3):251-7. Abstract

128. Gong A, Minuk GY. Predictors of alcohol relapse following liver transplantation for alcohol-induced liver failure. consideration of "A-D" selection criteria. Ann Transplant. 2018 Feb 20;23:129-35.Full text  Abstract

129. Obed A, Bashir A, Stern S, et al. Severe acute alcoholic hepatitis and liver transplant: a never-ending mournful story. Clin Mol Hepatol. 2018 Dec;24(4):358-66.Full text  Abstract

130. Dunn W, Jamil LH, Brown LS, et al. MELD accurately predicts mortality in patients with alcoholic hepatitis. Hepatology. 2005 Feb;41(2):353-8.Full text  Abstract

131. Marot A, Dubois M, Trépo E, et al. Liver transplantation for alcoholic hepatitis: a systematic review with meta-analysis. PLoS One. 2018 Jan 11;13(1):e0190823.Full text  Abstract

132. Al-Saeedi M, Barout MH, Probst P, et al. Meta-analysis of patient survival and rate of alcohol relapse in liver-transplanted patients for acute alcoholic hepatitis. Langenbecks Arch Surg. 2018 Nov;403(7):825-36. Abstract

133. Lee BP, Mehta N, Platt L, et al. Outcomes of early liver transplantation for patients with severe alcoholic hepatitis. Gastroenterology. 2018 Aug;155(2):422-30.e1.Full text  Abstract

134. European Medicines Agency​. Quinolone- and fluoroquinolone-containing medicinal products. Mar 2019 [internet publication].Full text

135. Food and Drug Administration.​ FDA reinforces safety information about serious low blood sugar levels and mental health side effects with fluoroquinolone antibiotics; requires label changes. Jul 2018 [internet publication].Full text

136. Food and Drug Administration.​ FDA warns about increased risk of ruptures or tears in the aorta blood vessel with fluoroquinolone antibiotics in certain patients. Dec 2018 [internet publication].Full text

137. Singh V, Keisham A, Bhalla A, et al. Efficacy of granulocyte colony-stimulating factor and N-acetylcysteine therapies in patients with severe alcoholic hepatitis. Clin Gastroenterol Hepatol. 2018 Oct;16(10):1650-6.Full text  Abstract

138. Baig M, Walayat S, Dhillon S, et al. Efficacy of granulocyte colony stimulating factor in severe alcoholic hepatitis: a systematic review and meta-Aanalysis. Cureus. 2020 Sep 15;12(9):e10474.Full text  Abstract

139. Marot A, Singal AK, Moreno C, et al. Granulocyte colony-stimulating factor for alcoholic hepatitis: a systematic review and meta-analysis of randomised controlled trials. JHEP Rep. 2020 Oct;2(5):100139.Full text  Abstract

140. Thompson J, Jones N, Al-Khafaji A, et al. Extracorporeal cellular therapy (ELAD) in severe alcoholic hepatitis: a multinational, prospective, controlled, randomized trial. Liver Transpl. 2018 Mar;24(3):380-93.Full text  Abstract

141. Philips CA, Pande A, Shasthry SM, et al. Healthy donor fecal microbiota transplantation in steroid-ineligible severe alcoholic hepatitis: a pilot study. Clin Gastroenterol Hepatol. 2017 Apr;15(4):600-2. Abstract

142. Nguyen-Khac E, Thevenot T, Piquet MA, et al. Glucocorticoids plus N-acetylcysteine in severe alcoholic hepatitis. N Engl J Med. 2011;365:1781-1789.Full text  Abstract

143. Singh S, Murad MH, Chandar AK, et al. Comparative effectiveness of pharmacological interventions for severe alcoholic hepatitis: a systematic review and network meta-analysis. Gastroenterology. 2015 Oct;149(4):958-70.e12.Full text  Abstract

144. American Association For the Study of Liver Diseases; Infectious Diseases Society of America. Testing, evaluation, and monitoring of hepatitis C. Oct 2022 [internet publication].Full text

145. Andrews CN, Devlin SM, Le Foll B, et al. Canadian Association of Gastroenterology position statement: use of cannabis in gastroenterological and hepatic disorders. J Can Assoc Gastroenterol. 2019 Apr;2(1):37-43.Full text  Abstract

146. Mitchell MC, Friedman LS, McClain CJ. Medical management of severe alcoholic hepatitis: expert review from the clinical practice updates committee of the AGA Institute. Clin Gastroenterol Hepatol. 2017 Jan;15(1):5-12.Full text  Abstract

147. European Association for the Study of the Liver. EASL recommendations on treatment of hepatitis C: final update of the series. J Hepatol. 2020 Nov;73(5):1170-218.Full text  Abstract

148. European Association for the Study of the Liver. EASL clinical practice guidelines on nutrition in chronic liver disease. J Hepatol. 2019 Jan;70(1):172-93.Full text  Abstract

149. Saunders JB, Latt N. Epidemiology of alcoholic liver disease. Baillieres Clin Gastroenterol. 1993 Sep;7(3):555-79. Abstract

150. Maddrey WC, Boitnott JK, Bedine MS, et al. Corticosteroid therapy of alcoholic hepatitis. Gastroenterology. 1978 Aug;75(2):193-9. Abstract

151. Ramond MJ, Poynard T, Rueff B, et al. A randomized trial of prednisolone in patients with severe alcoholic hepatitis. N Engl J Med. 1992 Feb 20;326(8):507-12.Full text  Abstract

152. Forrest EH, Evans CD, Stewart S, et al. Analysis of factors predictive of mortality in alcoholic hepatitis and derivation and validation of the Glasgow alcoholic hepatitis score. Gut. 2005 Aug;54(8):1174-9.Full text  Abstract

153. Bajaj JS, Saeian K, Schubert CM, et al. Minimal hepatic encephalopathy is associated with motor vehicle crashes: the reality beyond the driving test. Hepatology. 2009 Oct;50(4):1175-83. Abstract

154. Chavez-Tapia NC, Barrientos-Gutierrez T, Tellez-Avila FI, et al. Antibiotic prophylaxis for cirrhotic patients with upper gastrointestinal bleeding. Cochrane Database Syst Rev. 2010 Sep 8;(9):CD002907. Abstract

155. Garcia-Tsao G, Sanyal AJ, Grace ND, et al; Practice Guidelines Committee of American Association for Study of Liver Diseases; Practice Parameters Committee of American College of Gastroenterology. Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Am J Gastroenterol. 2007 Sep;102(9):2086-102. Abstract

156. Villanueva C, Colomo A, Bosch A, et al. Transfusion strategies for acute upper gastrointestinal bleeding. N Engl J Med. 2013 Jan 3;368(1):11-21.Full text  Abstract

157. Karwa R, Woodis CB. Midodrine and octreotide in treatment of cirrhosis-related hemodynamic complications. Ann Pharmacother. 2009 Apr;43(4):692-9. Abstract

158. Centers for Disease Control and Prevention. Adult immunization schedule by age: recommendations for ages 19 years or older, United States, 2024​. Nov 2023 [internet publication].Full text

159. Speeg KV, Bay MK. Prevention and treatment of drug-induced liver disease. Gastroenterol Clin North Am. 1995 Dec;24(4):1047-64. Abstract

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