References
Key articles
Mulhall JP, Trost LW, Brannigan RE, et al. Evaluation and management of testosterone deficiency: AUA guideline. J Urol. 2018 Aug;200(2):423-32.Full text Abstract
Jayasena CN, Anderson RA, Llahana S, et al. Society for Endocrinology guidelines for testosterone replacement therapy in male hypogonadism. Clin Endocrinol (Oxf). 2022 Feb;96(2):200-19.Full text Abstract
Matsumoto AM. Diagnosis and evaluation of hypogonadism. Endocrinol Metab Clin North Am. 2022 Mar;51(1):47-62. Abstract
Bhasin S, Brito JP, Cunningham GR, et al. Testosterone therapy in men with hypogonadism: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2018 May 1;103(5):1715-44.Full text Abstract
European Association of Urology. EAU guidelines on sexual and reproductive health. 2024 [internet publication].Full text
Reference articles
1. Mulhall JP, Trost LW, Brannigan RE, et al. Evaluation and management of testosterone deficiency: AUA guideline. J Urol. 2018 Aug;200(2):423-32.Full text Abstract
2. Jayasena CN, Anderson RA, Llahana S, et al. Society for Endocrinology guidelines for testosterone replacement therapy in male hypogonadism. Clin Endocrinol (Oxf). 2022 Feb;96(2):200-19.Full text Abstract
3. Salonia A, Rastrelli G, Hackett G, et al. Paediatric and adult-onset male hypogonadism. Nat Rev Dis Primers. 2019 May 30;5(1):38.Full text Abstract
4. Sharma A, Jayasena CN, Dhillo WS. Regulation of the hypothalamic-pituitary-testicular axis: pathophysiology of hypogonadism. Endocrinol Metab Clin North Am. 2022 Mar;51(1):29-45. Abstract
5. Tajar A, Forti G, O'Neill TW, et al; EMAS Group. Characteristics of secondary, primary, and compensated hypogonadism in aging men: evidence from the European male ageing study. J Clin Endocrinol Metab. 2010 Apr;95(4):1810-8. Abstract
6. Wu FC, Tajar A, Beynon JM, et al. Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med. 2010 Jul 8;363(2):123-35.Full text Abstract
7. Matsumoto AM. Diagnosis and evaluation of hypogonadism. Endocrinol Metab Clin North Am. 2022 Mar;51(1):47-62. Abstract
8. Dwyer AA, Smith N, Quinton R. Psychological aspects of congenital hypogonadotropic hypogonadism. Front Endocrinol (Lausanne). 2019 Jul 5;10:353.Full text Abstract
9. Thirumalai A, Anawalt BD. Epidemiology of male hypogonadism. Endocrinol Metab Clin North Am. 2022 Mar;51(1):1-27.Full text Abstract
10. Araujo AB, Esche GR, Kupelian V, et al. Prevalence of symptomatic androgen deficiency in men. J Clin Endocrinol Metab. 2007 Nov;92(11):4241-7.Full text Abstract
11. Lee DM, Pye SR, Tajar A, et al. Cohort profile: the European Male Ageing Study. Int J Epidemiol. 2013 Apr;42(2):391-401.Full text Abstract
12. Wu FC, Tajar A, Pye SR, et al. Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study. J Clin Endocrinol Metab. 2008 Jul;93(7):2737-45.Full text Abstract
13. Tajar A, Huhtaniemi IT, O'Neill TW, et al. Characteristics of androgen deficiency in late-onset hypogonadism: results from the European Male Aging Study (EMAS). J Clin Endocrinol Metab. 2012 May;97(5):1508-16.Full text Abstract
14. Cheng J, Han B, Li Q, et al. Testosterone: relationships with metabolic disorders in men-an observational study from SPECT-China. Int J Endocrinol. 2017;2017:4547658.Full text Abstract
15. Groth KA, Skakkebæk A, Høst C, et al. Clinical review: Klinefelter syndrome - a clinical update. J Clin Endocrinol Metab. 2013 Jan;98(1):20-30.Full text Abstract
16. Gravholt CH, Chang S, Wallentin M, et al. Klinefelter syndrome: integrating genetics, neuropsychology, and endocrinology. Endocr Rev. 2018 Aug 1;39(4):389-423.Full text Abstract
17. Delessard M, Saulnier J, Rives A, et al. Exposure to chemotherapy during childhood or adulthood and consequences on spermatogenesis and male fertility. Int J Mol Sci. 2020 Feb 20;21(4):1454.Full text Abstract
18. Chiba K, Ramasamy R, Lamb DJ, et al. The varicocele: diagnostic dilemmas, therapeutic challenges and future perspectives. Asian J Androl. 2016 Mar-Apr;18(2):276-81.Full text Abstract
19. Thornton CA. Myotonic dystrophy. Neurol Clin. 2014 Aug;32(3):705-19, viii. Abstract
20. Arnold FJ, Merry DE. Molecular mechanisms and therapeutics for SBMA/Kennedy's disease. Neurotherapeutics. 2019 Oct;16(4):928-47.Full text Abstract
21. Roychoudhury S, Chakraborty S, Choudhury AP, et al. Environmental factors-induced oxidative stress: hormonal and molecular pathway disruptions in hypogonadism and erectile dysfunction. Antioxidants (Basel). 2021 May 24;10(6):837.Full text Abstract
22. Duca Y, Aversa A, Condorelli RA, et al. Substance abuse and male hypogonadism. J Clin Med. 2019 May 22;8(5):732.Full text Abstract
23. Claahsen-van der Grinten HL, Stikkelbroeck N, Falhammar H, et al. Management of endocrine disease: gonadal dysfunction in congenital adrenal hyperplasia. Eur J Endocrinol. 2021 Mar;184(3):R85-97. Abstract
24. Fang Q, George AS, Brinkmeier ML, et al. Genetics of combined pituitary hormone deficiency: roadmap into the genome era. Endocr Rev. 2016 Dec;37(6):636-75.Full text Abstract
25. Kiserud CE, Fosså A, Bjøro T, et al. Gonadal function in male patients after treatment for malignant lymphomas, with emphasis on chemotherapy. Br J Cancer. 2009 Feb 10;100(3):455-63.Full text Abstract
26. Luton JP, Thieblot P, Valcke JC, et al. Reversible gonadotropin deficiency in male Cushing's disease. J Clin Endocrinol Metab. 1977 Sep;45(3):488-95. Abstract
27. Lunenfeld B, Mskhalaya G, Zitzmann M, et al. Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men. Aging Male. 2015 Mar;18(1):5-15.Full text Abstract
28. Wang C, Nieschlag E, Swerdloff R, et al. Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA and ASA recommendations. Eur J Endocrinol. 2008 Nov;159(5):507-14.Full text Abstract
29. Wang C, Jackson G, Jones TH, et al. Low testosterone associated with obesity and the metabolic syndrome contributes to sexual dysfunction and cardiovascular disease risk in men with type 2 diabetes. Diabetes Care. 2011 Jul;34(7):1669-75.Full text Abstract
30. Dhindsa S, Ghanim H, Batra M, et al. Hypogonadotropic hypogonadism in men with diabesity. Diabetes Care. 2018 Jul;41(7):1516-25.Full text Abstract
31. Dandona P, Dhindsa S, Ghanim H. Hypogonadotropic hypogonadism in diabesity: pathogenic factors and therapeutic implications. Androg Clin Res Ther. 2022 Dec 28;3(1):214-6.Full text Abstract
32. Rochira V, Kara E, Carani C. The endocrine role of estrogens on human male skeleton. Int J Endocrinol. 2015;2015:165215.Full text Abstract
33. Braunstein GD. Gynecomastia. N Engl J Med. 2007 Sep 20;357(12):1229-37. Abstract
34. Bhasin S, Brito JP, Cunningham GR, et al. Testosterone therapy in men with hypogonadism: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2018 May 1;103(5):1715-44.Full text Abstract
35. Ring J, Welliver C, Parenteau M, et al. The utility of sex hormone-binding globulin in hypogonadism and infertile males. J Urol. 2017 May;197(5):1326-31. Abstract
36. Paduch DA, Brannigan RE, Fuchs EF, et al. The laboratory diagnosis of testosterone deficiency. Urology. 2014 May;83(5):980-8. Abstract
37. World Health Organization. WHO laboratory manual for the examination and processing of human semen. Sixth edition. 2021 [internet publication].Full text
38. European Association of Urology. EAU guidelines on sexual and reproductive health. 2024 [internet publication].Full text
39. Hackett G, Kirby M, Rees RW, et al. The British Society for Sexual Medicine guidelines on male adult testosterone deficiency, with statements for practice. World J Mens Health. 2023 Jul;41(3):508-37.Full text Abstract
40. Lee H, Hwang EC, Oh CK, et al. Testosterone replacement in men with sexual dysfunction. Cochrane Database Syst Rev. 2024 Jan 15;1(1):CD013071.Full text Abstract
41. Cappola AR, Auchus RJ, El-Hajj Fuleihan G, et al. Hormones and aging: an Endocrine Society scientific statement. J Clin Endocrinol Metab. 2023 Jul 14;108(8):1835-74.Full text Abstract
42. Elliott J, Kelly SE, Millar AC, et al. Testosterone therapy in hypogonadal men: a systematic review and network meta-analysis. BMJ Open. 2017 Nov 16;7(11):e015284.Full text Abstract
43. Wang C, Swerdloff RS. Testosterone replacement therapy in hypogonadal men. Endocrinol Metab Clin North Am. 2022 Mar;51(1):77-98. Abstract
44. Figueiredo MG, Gagliano-Jucá T, Basaria S. Testosterone therapy with subcutaneous injections: a safe, practical, and reasonable option. J Clin Endocrinol Metab. 2022 Feb 17;107(3):614-26.Full text Abstract
45. Fallara G, Pozzi E, Belladelli F, et al. Cardiovascular morbidity and mortality in men - findings from a meta-analysis on the time-related measure of risk of exogenous testosterone. J Sex Med. 2022 Aug;19(8):1243-54. Abstract
46. Corona G, Maseroli E, Rastrelli G, et al. Cardiovascular risk associated with testosterone-boosting medications: a systematic review and meta-analysis. Expert Opin Drug Saf. 2014 Oct;13(10):1327-51. Abstract
47. Albert SG, Morley JE. Testosterone therapy, association with age, initiation and mode of therapy with cardiovascular events: a systematic review. Clin Endocrinol (Oxf). 2016 Sep;85(3):436-43. Abstract
48. Lincoff AM, Bhasin S, Flevaris P, et al. Cardiovascular safety of testosterone-replacement therapy. N Engl J Med. 2023 Jul 13;389(2):107-17. Abstract
49. Ayele HT, Brunetti VC, Renoux C, et al. Testosterone replacement therapy and the risk of venous thromboembolism: a systematic review and meta-analysis of randomized controlled trials. Thromb Res. 2021 Mar;199:123-31. Abstract
50. Walker RF, Zakai NA, MacLehose RF, et al. Association of testosterone therapy with risk of venous thromboembolism among men with and without hypogonadism. JAMA Intern Med. 2020 Feb 1;180(2):190-7.Full text Abstract
51. Carson CC 3rd, Rosano G. Exogenous testosterone, cardiovascular events, and cardiovascular risk factors in elderly men: a review of trial data. J Sex Med. 2012 Jan;9(1):54-67. Abstract
52. Malkin CJ, Pugh PJ, Jones RD, et al. The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men. J Clin Endocrinol Metab. 2004 Jul;89(7):3313-8.Full text Abstract
53. Hackett G, Cole N, Saghir A, et al. Testosterone replacement therapy: improved sexual desire and erectile function in men with type 2 diabetes following a 30-week randomized placebo-controlled study. Andrology. 2017 Sep;5(5):905-13. Abstract
54. Wittert G, Bracken K, Robledo KP, et al. Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trial. Lancet Diabetes Endocrinol. 2021 Jan;9(1):32-45. Abstract
55. US Food and Drug Administration. FDA drug safety communication: FDA cautions about using testosterone products for low testosterone due to aging; requires labeling change to inform of possible increased risk of heart attack and stroke with use. February 2018 [internet publication].Full text
56. European Medicines Agency. No consistent evidence of an increased risk of heart problems with testosterone medicines. November 2014 [internet publication].Full text
57. Jick SS, Hagberg KW. The risk of adverse outcomes in association with use of testosterone products: a cohort study using the UK-based general practice research database. Br J Clin Pharmacol. 2013 Jan;75(1):260-70.Full text Abstract
58. Pastuszak AW, Hu Y, Freid JD. Occurrence of pulmonary oil microembolism after testosterone undecanoate injection: a postmarketing safety analysis. Sex Med. 2020 Jun;8(2):237-42.Full text Abstract
59. Melmed S, Casanueva FF, Hoffman AR, et al. Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011 Feb;96(2):273-88.Full text Abstract
60. Micko A, Vila G, Höftberger R, et al. Endoscopic transsphenoidal surgery of microprolactinomas: a reappraisal of cure rate based on radiological criteria. Neurosurgery. 2019 Oct 1;85(4):508-15. Abstract
61. Zamanipoor Najafabadi AH, Zandbergen IM, de Vries F, et al. Surgery as a viable alternative first-line treatment for prolactinoma patients. A systematic review and meta-analysis. J Clin Endocrinol Metab. 2020 Mar 1;105(3):e32-41.Full text Abstract
62. Rastrelli G, Corona G, Mannucci E, et al. Factors affecting spermatogenesis upon gonadotropin-replacement therapy: a meta-analytic study. Andrology. 2014 Nov;2(6):794-808.Full text Abstract
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