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Small cell lung cancer

Última revisão: 4 May 2025
Última atualização: 29 Apr 2025

Resumo

Definição

História e exame físico

Principais fatores diagnósticos

  • cough
  • dyspnea
  • hemoptysis
  • chest pain
  • weight loss
Detalhes completos

Outros fatores diagnósticos

  • age 65 to 74 years
  • male sex
  • fatigue
  • pulmonary exam abnormalities
  • hoarseness
  • confusion
  • personality changes
  • nausea and vomiting
  • headache
  • dysphagia
  • bone pain and/or fractures
  • seizures
  • cervical or supraclavicular adenopathy
  • facial swelling
  • dilated neck or chest/abdominal wall veins
  • finger clubbing
  • hypertrophic osteoarthropathy
Detalhes completos

Fatores de risco

  • cigarette smoking
  • environmental tobacco exposure
  • radon gas exposure
  • asbestos exposure
Detalhes completos

Investigações diagnósticas

Primeiras investigações a serem solicitadas

  • chest x-ray
  • CT chest, liver, and adrenal glands
Detalhes completos

Investigações a serem consideradas

  • bronchoscopy
  • biopsy
  • thoracentesis
  • thoracoscopy
  • MRI or CT of brain
  • mediastinoscopy
  • fluorodeoxyglucose positron emission tomography (FDG PET/CT)
  • bone scan
  • bone marrow aspirate and biopsy
  • CBC
  • LFTs
  • serum sodium
  • renal function
  • lung function tests
Detalhes completos

Algoritmo de tratamento

AGUDA

at initial presentation: limited disease

at initial presentation: extensive disease

CONTÍNUA

relapse within 6 months

relapse after 6 months

Colaboradores

Autores

Bingnan Zhang, MD, MBA

Assistant Professor

Department of Thoracic/Head and Neck Medical Oncology

Division of Cancer Medicine

The University of Texas MD Anderson Cancer Center

Houston

TX

Declarações

BZ declares that she has no competing interests.

Agradecimentos

Dr Bingnan Zhang would like to gratefully acknowledge Dr Leena Gandhi, Dr Alvin R. Cabrera, Dr Christopher R. Kelsey, Dr Lawrence B. Marks, Dr Rebecca Suk Heist, and Dr Catherine B. Meador, previous contributors to this topic.

Declarações

LG, ARC, CRK, and LBM declare that they have no competing interests. RSH has received honoraria for consulting from Novartis, Abbvie, Daichii Sankyo, and EMD Serono. RSH's institution (not RSH) has received research funding from Agios, Abbvie, Exelixis, Daichii Sankyo, Novartis, Lilly, Mirati, Corvus, Incyte, and Genentech Roche.

Revisores

Alan Neville, MD

Professor

Assistant Dean

Undergraduate Program

McMaster University

Hamilton

Ontario

Canada

Declarações

AN declares that he has no competing interests.

Referências

Nossas equipes internas de editoria e de evidências trabalham em conjunto com colaboradores internacionais especializados e pares revisores para garantir que forneçamos acesso às informações o mais clinicamente relevantes possível.

Principais artigos

National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: small cell lung cancer [internet publication].Texto completo

Dingemans AC, Früh M, Ardizzoni A, et al. Small-cell lung cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2021 Jul;32(7):839-53.Texto completo  Resumo

National Institute for Health and Care Excellence. Lung cancer: diagnosis and management. Mar 2024 [internet publication].Texto completo

Simone CB 2nd, Bogart JA, Cabrera AR, et al. Radiation therapy for small cell lung cancer: an ASTRO clinical practice guideline. Pract Radiat Oncol. 2020 May - Jun;10(3):158-73.Texto completo  Resumo

Artigos de referência

Uma lista completa das fontes referenciadas neste tópico está disponível para os usuários com acesso total ao BMJ Best Practice.
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    • Lung cancer: diagnosis and management
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  • Folhetos informativos para os pacientes

    Lung cancer: questions to ask your doctor

    Bronchoscopy

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