Resumo
Definição
História e exame físico
Principais fatores diagnósticos
- cough
- dyspnea
- hemoptysis
- chest pain
- weight loss
Outros fatores diagnósticos
- age 65 to 74 years
- male sex
- fatigue
- pulmonary exam abnormalities
- hoarseness
- confusion
- personality changes
- nausea and vomiting
- headache
- dysphagia
- bone pain and/or fractures
- seizures
- cervical or supraclavicular adenopathy
- facial swelling
- dilated neck or chest/abdominal wall veins
- finger clubbing
- hypertrophic osteoarthropathy
Fatores de risco
- cigarette smoking
- environmental tobacco exposure
- radon gas exposure
- asbestos exposure
Investigações diagnósticas
Primeiras investigações a serem solicitadas
- chest x-ray
- CT chest, liver, and adrenal glands
Investigações a serem consideradas
- bronchoscopy
- biopsy
- thoracentesis
- thoracoscopy
- MRI or CT of brain
- mediastinoscopy
- fluorodeoxyglucose positron emission tomography (FDG PET/CT)
- bone scan
- bone marrow aspirate and biopsy
- CBC
- LFTs
- serum sodium
- renal function
- lung function tests
Algoritmo de tratamento
at initial presentation: limited disease
at initial presentation: extensive disease
relapse within 6 months
relapse after 6 months
Colaboradores
Autores
Bingnan Zhang, MD, MBA
Assistant Professor
Department of Thoracic/Head and Neck Medical Oncology
Division of Cancer Medicine
The University of Texas MD Anderson Cancer Center
Houston
TX
Declarações
BZ declares that she has no competing interests.
Agradecimentos
Dr Bingnan Zhang would like to gratefully acknowledge Dr Leena Gandhi, Dr Alvin R. Cabrera, Dr Christopher R. Kelsey, Dr Lawrence B. Marks, Dr Rebecca Suk Heist, and Dr Catherine B. Meador, previous contributors to this topic.
Declarações
LG, ARC, CRK, and LBM declare that they have no competing interests. RSH has received honoraria for consulting from Novartis, Abbvie, Daichii Sankyo, and EMD Serono. RSH's institution (not RSH) has received research funding from Agios, Abbvie, Exelixis, Daichii Sankyo, Novartis, Lilly, Mirati, Corvus, Incyte, and Genentech Roche.
Revisores
Alan Neville, MD
Professor
Assistant Dean
Undergraduate Program
McMaster University
Hamilton
Ontario
Canada
Declarações
AN declares that he has no competing interests.
Referências
Principais artigos
National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: small cell lung cancer [internet publication].Texto completo
Dingemans AC, Früh M, Ardizzoni A, et al. Small-cell lung cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2021 Jul;32(7):839-53.Texto completo Resumo
National Institute for Health and Care Excellence. Lung cancer: diagnosis and management. Mar 2024 [internet publication].Texto completo
Simone CB 2nd, Bogart JA, Cabrera AR, et al. Radiation therapy for small cell lung cancer: an ASTRO clinical practice guideline. Pract Radiat Oncol. 2020 May - Jun;10(3):158-73.Texto completo Resumo
Artigos de referência
Uma lista completa das fontes referenciadas neste tópico está disponível para os usuários com acesso total ao BMJ Best Practice.
Diagnósticos diferenciais
- Non-small cell lung cancer
- Pneumonia/bronchitis
- Carcinoid tumor
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