Epidemiology

The epidemiology of TM depends on its underlying cause. The annual incidence of idiopathic complete TM is uncertain, but conservative estimates based on studies in US, European, and Israeli populations range from 1 to 4 cases per million, with a bimodal distribution of age presentation, peaking at ages 10 to 19 and 30 to 39 years.[10][11][12][13][14] A population-based study estimated a mean annual incidence rate of 0.82 per 100,000 person-years, or 1.2 per 100,000 person-years for adults.[15] However, these studies preceded the discovery of the aquaporin-4-IgG and myelin oligodendrocyte glycoprotein-IgG auto-antibodies, which have provided a definable aetiology for some TM previously thought to be idiopathic.[16][17]

BMJ Best Practice is an evidence-based point of care tool for healthcare practitioners.

To continue reading and access all of BMJ Best Practice's pages you'll need to log in or start a free trial.

You can access through your institution if your hospital, university, trust or other institution provides access to BMJ Best Practice through either OpenAthens or Shibboleth.

Use of this content is subject to our disclaimer