Last reviewed:December 2019
Last updated:April  2019

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • limb weakness
  • dry mouth
  • weakness

Other diagnostic factors

  • dysarthria
  • areflexia
  • ptosis
  • diplopia
  • impotence
  • dysphagia
  • orthostatic hypotension
  • pupillary dilation
  • dyspnoea
  • cerebellar ataxia

Risk factors

  • underlying small cell lung cancer or other malignancy
  • co-existing autoimmune disorder
  • cigarette smoking
  • family history of autoimmune disease

Diagnostic investigations

Treatment algorithm

Contributors

Staff Neurologist

University of Tennessee Erlanger Neurology

Chattanooga

TN

Disclosures

JPA declares that he has no competing interests.

Associate Professor of Neurology

Department of Neurology

Duke University Medical Center

Durham

NC

Disclosures

VCJ declares that he has no competing interests.

Peer reviewersVIEW ALL

Assistant Professor

Medical University of South Carolina

Charleston

SC

Disclosures

DS declares that he has no competing interests.

Associate Professor

Division of Neurology

University of Alberta

Edmonton

Canada

Disclosures

ZS declares that he has no competing interests.

Department of Neurology

Haga Hospital

The Hague

The Netherlands

Disclosures

PW is an author of a number of references cited in this monograph.

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