Last reviewed:December 2019
Last updated:June  2019

Summary

Definition

History and exam

Key diagnostic factors

  • presence of risk factors
  • chills
  • flushing
  • dyspnoea
  • fever
  • chest, abdominal, flank, and back pain
  • hypotension
  • bleeding from mucous membranes, GI tract, or urinary tract

Other diagnostic factors

  • headache
  • nausea and vomiting
  • anxiety
  • pain along the infused extremity
  • pruritus
  • urticaria
  • angio-oedema
  • jaundice
  • rales
  • red urine
  • stridor or bronchospasm
  • pallor
  • maculopapular rash
  • diarrhoea
  • disseminated purpura
  • exfoliative dermatitis with mucocutaneous involvement

Risk factors

  • prior pregnancy
  • previous transfusion
  • history of transplantation
  • IgA deficiency
  • immunocompromise
  • history of transfusion reaction

Diagnostic investigations

Treatment algorithm

Contributors

Associate Professor of Surgery

Creighton University School of Medicine

St. Joseph’s Hospital and Medical Center

Phoenix

AZ

Disclosures

JAW declares that he has no competing interests.

Peer reviewersVIEW ALL

Associate Professor of Medicine

Innsbruck Medical University

Innsbruck

Austria

Disclosures

CP declares that he has no competing interests.

Professor of Pathology

University of Alabama at Birmingham Hospital

Birmingham

AL

Disclosures

MM declares that she has no competing interests.

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