Most clinically non-functional pituitary adenomas (CNFPAs) present late because they either do not secrete any hormones or they secrete functional hormones inefficiently. They rarely produce intact glycoprotein follicle-stimulating hormone (FSH) and luteinising hormone (LH), but more commonly produce varying combinations of either FSH beta subunit and/or LH beta subunit along with the common alpha subunit. Mean age of presentation is 50 to 55 years.
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