A total of 1207 cases of Reye's syndrome were reported to the Centers for Disease Control and Prevention (CDC) in the US between 1980 and 1997.[5] The peak incidence occurred in 1980, with 555 cases reported. The incidence has steadily declined since 1980, possibly due to over-diagnosis in previous years, improved metabolic testing, lower prevalence of influenza, and a decline in paediatric aspirin consumption. Since 1994, there have been 2 or fewer cases reported per year in the US. The 2009 incidence is thought to be between <0.3 and 1.0/100,000 in people under 18 years old.[6][7][8] The exact incidence is difficult to establish because reporting cases of Reye's syndrome to the CDC in the US is no longer mandated.[9]

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