A total of 1207 cases of Reye's syndrome were reported to the Centers for Disease Control and Prevention (CDC) in the US between 1980 and 1997. The peak incidence occurred in 1980, with 555 cases reported. The incidence has steadily declined since 1980, possibly due to over-diagnosis in previous years, improved metabolic testing, lower prevalence of influenza, and a decline in paediatric aspirin consumption. Since 1994, there have been 2 or fewer cases reported per year in the US. The 2009 incidence is thought to be between <0.3 and 1.0/100,000 in people under 18 years old. The exact incidence is difficult to establish because reporting cases of Reye's syndrome to the CDC in the US is no longer mandated.
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