Summary
Definition
Anamnesis y examen
Principales factores de diagnóstico
- vomiting
- altered mental status
Otros factores de diagnóstico
- hyperventilation
- hepatomegaly
- abnormal pupillary response
- hyperreflexia/areflexia
- diminished pain response
- seizures
- absence of, or minimal, jaundice and scleral icterus
Factores de riesgo
- age 5-14 years
- white ethnicity
- recent viral infection
- aspirin (acetylsalicylic acid) and other drug exposure
- genetically predisposed individual
- toxin exposure
- winter/spring presentation
Pruebas diagnósticas
Primeras pruebas diagnósticas para solicitar
- serum electrolytes
- serum glucose
- LFTs
- serum ammonia
- PT/PTT
- urine/serum toxicology
- urinalysis
- blood gas
Pruebas diagnósticas que deben considerarse
- cranial CT
- lumbar puncture with cerebrospinal fluid analysis
- EEG
- liver biopsy
- metabolic testing
Algoritmo de tratamiento
all patients
Colaboradores
Autores
Vanessa G. Carroll, MD, FAAP
Medical Director of Pediatric Hospital Medicine
Kootenai Health
Coeur d’Alene
ID
Divulgaciones
VGC declares that she has no competing interests.
Russell W. Steele, MD, FAAP
Section Head of Pediatric Infectious Diseases
Ochsner Medical Center for Children
New Orleans
LA
Divulgaciones
RWS declares that he has no competing interests.
Agradecimientos
Dr Vanessa G. Carroll and Dr Russell W. Steele would like to gratefully acknowledge Dr Barry M. Starr, a previous contributor to this topic. BMS declares that he has no competing interests.
Revisores por pares
William F. Balistreri, MD
Professor of Pediatrics
Cincinnati Children's Hospital Medical Center
Cincinnati
OH
Divulgaciones
WFB declares that he has no competing interests.
Bernard Portmann, MD, FRCPath
Consultant Histopathologist
Institute of Liver Studies
King's College Hospital
London
UK
Divulgaciones
BP declares that he has no competing interests.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
Referencias
Artículos principales
Centers for Disease Control and Prevention. Reye syndrome: 1990 clinical case definition. 1990 [internet publication].Texto completo
Hurwitz ES, Nelson DB, Davis C, et al. National surveillance for Reye syndrome: a five-year review. Pediatrics. 1982 Dec;70(6):895-900. Resumen
Belay ED, Bresee JS, Holman RC, et al. Reye's syndrome in the United States from 1981 through 1997. N Engl J Med. 1999 May 6;340(18):1377-82.Texto completo Resumen
Royal College of Paediatrics and Child Health. Management of children and young people with an acute decrease in conscious level. Mar 2019 [internet publication].Texto completo
Hardie RM, Newton LH, Bruce JC, et al. The changing clinical pattern of Reye's syndrome 1982-1990. Arch Dis Child. 1996 May;74(5):400-45. Resumen
Artículos de referencia
Una lista completa de las fuentes a las que se hace referencia en este tema está disponible para los usuarios con acceso a todo BMJ Best Practice.
Diferenciales
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Más DiferencialesGuidelines
- Management of children and young people with an acute decrease in conscious level
- Reye syndrome: 1990 case definition
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