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Reye syndrome

Last reviewed: 13 Sep 2025
Last updated: 19 Apr 2023

Summary

Definition

Anamnesis y examen

Principales factores de diagnóstico

  • vomiting
  • altered mental status
Todos los datos

Otros factores de diagnóstico

  • hyperventilation
  • hepatomegaly
  • abnormal pupillary response
  • hyperreflexia/areflexia
  • diminished pain response
  • seizures
  • absence of, or minimal, jaundice and scleral icterus
Todos los datos

Factores de riesgo

  • age 5-14 years
  • white ethnicity
  • recent viral infection
  • aspirin (acetylsalicylic acid) and other drug exposure
  • genetically predisposed individual
  • toxin exposure
  • winter/spring presentation
Todos los datos

Pruebas diagnósticas

Primeras pruebas diagnósticas para solicitar

  • serum electrolytes
  • serum glucose
  • LFTs
  • serum ammonia
  • PT/PTT
  • urine/serum toxicology
  • urinalysis
  • blood gas
Todos los datos

Pruebas diagnósticas que deben considerarse

  • cranial CT
  • lumbar puncture with cerebrospinal fluid analysis
  • EEG
  • liver biopsy
  • metabolic testing
Todos los datos

Algoritmo de tratamiento

Agudo

all patients

Colaboradores

Autores

Vanessa G. Carroll, MD, FAAP

Medical Director of Pediatric Hospital Medicine

Kootenai Health

Coeur d’Alene

ID

Divulgaciones

VGC declares that she has no competing interests.

Russell W. Steele, MD, FAAP

Section Head of Pediatric Infectious Diseases

Ochsner Medical Center for Children

New Orleans

LA

Divulgaciones

RWS declares that he has no competing interests.

Agradecimientos

Dr Vanessa G. Carroll and Dr Russell W. Steele would like to gratefully acknowledge Dr Barry M. Starr, a previous contributor to this topic. BMS declares that he has no competing interests.

Revisores por pares

William F. Balistreri, MD

Professor of Pediatrics

Cincinnati Children's Hospital Medical Center

Cincinnati

OH

Divulgaciones

WFB declares that he has no competing interests.

Bernard Portmann, MD, FRCPath

Consultant Histopathologist

Institute of Liver Studies

King's College Hospital

London

UK

Divulgaciones

BP declares that he has no competing interests.

Peer reviewer acknowledgements

BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.

Disclosures

Peer reviewer affiliations and disclosures pertain to the time of the review.

Referencias

Nuestros equipos internos de evidencia y editoriales colaboran con colaboradores expertos internacionales y revisores pares para garantizar que brindemos acceso a la información más clínicamente relevante posible.

Artículos principales

Centers for Disease Control and Prevention. Reye syndrome: 1990 clinical case definition. 1990 [internet publication].Texto completo

Hurwitz ES, Nelson DB, Davis C, et al. National surveillance for Reye syndrome: a five-year review. Pediatrics. 1982 Dec;70(6):895-900. Resumen

Belay ED, Bresee JS, Holman RC, et al. Reye's syndrome in the United States from 1981 through 1997. N Engl J Med. 1999 May 6;340(18):1377-82.Texto completo  Resumen

Royal College of Paediatrics and Child Health. Management of children and young people with an acute decrease in conscious level. Mar 2019 [internet publication].Texto completo

Hardie RM, Newton LH, Bruce JC, et al. The changing clinical pattern of Reye's syndrome 1982-1990. Arch Dis Child. 1996 May;74(5):400-45. Resumen

Artículos de referencia

Una lista completa de las fuentes a las que se hace referencia en este tema está disponible para los usuarios con acceso a todo BMJ Best Practice.
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