The diagnosis of ALF is established through a careful history, including: chronology of events prior to presentation; physical examination; laboratory studies. Early recognition, diagnosis, and establishment of prognosis are paramount to providing an optimal management strategy in patients with ALF. Once the diagnosis is made, early contact with a liver transplant centre should be addressed, as all patients with ALF should be considered for possible liver transplantation.[39] Urgent cadaveric liver transplantation is the standard of care for patients with ALF.

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