The diagnosis of ALF is established through a careful history, including: chronology of events prior to presentation; physical examination; laboratory studies. Early recognition, diagnosis, and establishment of prognosis are paramount to providing an optimal management strategy in patients with ALF. Once the diagnosis is made, early contact with a liver transplant centre should be addressed, as all patients with ALF should be considered for possible liver transplantation. Urgent cadaveric liver transplantation is the standard of care for patients with ALF.
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