Last reviewed: November 2017
Last updated: November  2017

Summary

Differentials

Common

  • Monoclonal gammopathy of undetermined significance
  • Chronic lymphocytic leukemia
  • Non-Hodgkin lymphoma

Uncommon

  • Light chain deposition disease
  • Post-transplant monoclonal gammopathies
  • Multiple myeloma
  • Plasma cell leukemia
  • Waldenstrom macroglobulinemia
  • Solitary plasmacytoma
  • POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes)
  • Hepatitis C
  • HIV infection
  • Primary amyloidosis
  • Cryoglobulinemia
  • Systemic lupus erythematosus (SLE)
  • Rheumatoid arthritis
  • Psoriatic arthritis
  • Sjogren syndrome
  • Schnitzler syndrome

Contributors

Authors VIEW ALL

Professor of Medicine

Division of Hematology

Mayo Clinic

Rochester

MN

Disclosures

SK reports personal fees for Skyline Diagnostics, Noxxon Pharma, and Kessios Pharma and serves on advisory boards for Takeda, Celgene, Janssen, Abbvie, Bristol-Myers Squibb, and Merck.

Peer reviewers VIEW ALL

Associate Professor

University of Turin

Chief

Myeloma Unit

Ospedale Molinette

Turin

Italy

Disclosures

AP declares that he has no competing interests.

Price Eminent Scholar and Professor of Medicine Director

Bone Marrow Transplant Program

Division of Hematology and Oncology

University of Florida College of Medicine

Gainesville

FL

Disclosures

JRW declares that he has no competing interests.

Associate Professor of Clinical Medicine

Department of Medicine

Division of Hematology/Oncology

University of Virginia

Charlottesville

VA

Disclosures

JD declares that he has no competing interests.

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