Last reviewed: November 2017
Last updated: November  2017

Summary

Definition

History and exam

Key diagnostic factors

  • erythematous edematous lesions
  • pruritus
  • resolution within 24 hours
  • swelling of face, tongue, or lips

Other diagnostic factors

  • blanching lesions
  • stridor

Risk factors

  • positive family history
  • female gender
  • exposure to drug trigger
  • exposure to food trigger
  • recent viral infection
  • recent insect bite

Diagnostic investigations

Investigations to consider

  • CBC with differential
  • complete metabolic panel
  • urinalysis
  • erythrocyte sedimentation rate (ESR)
  • CRP
  • anti-IgE receptor antibody and related tests
  • thyroid-stimulating hormone (TSH)
  • antithyroid antibodies
  • antinuclear antibodies (ANA)
  • skin biopsy
  • C4 level
  • C1-esterase inhibitor level
  • C1-esterase inhibitor function
  • C1q levels
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Allergy and Clinical Immunology

Rochester Regional Health

Clinical Assistant Professor of Medicine

University of Rochester School of Medicine & Dentistry

Rochester

NY

Disclosures

SSM is on the speakers' panel and advisory board for Genentech.

Dr S. Shahzad Mustafa would like to gratefully acknowledge Dr Stephen Dreskin, a previous contributor to this monograph. SD declares that he has no competing interests.

Peer reviewers VIEW ALL

Consultant Dermatologist

Warwick Hospital

Honorary Associate Professor

University of Warwick

Warwick Hospital

Warwick

UK

Disclosures

FH has attended educational events organised and funded by Almrall and Schering Plough; has received speaker's fee from Steibel, Leo, and Schering Plough; and is an author of references cited in this monograph.

Consultant in Dermatology

University Hospital of South Manchester

Manchester

UK

Disclosures

None declared.

Head of Allergy and Training Program Director

Winthrop University Hospital

Associate Professor of Clinical Medicine

SUNY at Stony Brook

Stony Brook

NY

Disclosures

LF declares that she has no competing interests.

Professor of Medicine

Department of Internal Medicine

Division of Immunology/Allergy Section

University of Cincinnati

Cincinnati

OH

Disclosures

JB is the editor of the Joint Task Force Practice Parameters on Urticaria.

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