Last reviewed: November 2017
Last updated: November  2017



History and exam

Key diagnostic factors

  • polymorphous rash
  • conjunctival injection
  • mucositis
  • skin changes in the peripheral extremities
  • enlarged cervical lymph nodes
  • coronary artery aneurysms
  • fever and extreme irritability

Other diagnostic factors

  • pericarditis with effusion
  • congestive heart failure (CHF)
  • joint pain or edema
  • neurologic manifestations
  • gastrointestinal manifestations
  • urologic manifestations
  • other dermatologic manifestations

Risk factors

  • Asian ancestry
  • age 3 months to 4 years
  • male gender

Diagnostic investigations

1st investigations to order

  • CBC
  • serum erythrocyte sedimentation rate (ESR)
  • serum C-reactive protein (CRP)
  • serum liver function tests
  • urinalysis
  • chest x-ray
  • echocardiogram
  • ECG
Full details

Investigations to consider

  • ultrasonography of the gallbladder
  • ultrasonography of the testes
  • lumbar puncture
Full details

Emerging tests

  • magnetic resonance angiography
  • cardiac catheterization and angiography
Full details

Treatment algorithm


Authors VIEW ALL

Professor of Pediatrics and Chief

Division of Pediatric Rheumatology

LSU Health Sciences Center and Children's Hospital

New Orleans



AG declares that he has no competing interests.

Peer reviewers VIEW ALL

Editor in Chief

Journal of Clinical Pediatrics

Department of Pediatrics

Division of Infectious Diseases

Ochsner Children's Health Center

New Orleans



RWS declares that he has no competing interests.

Clinical Professor of Pediatrics

Department of Pediatrics

Oregon Health Science University




JLE declares that he has no competing interests.

Principal Research Fellow

Murdoch Childrens Research Institute

The Royal Children’s Hospital




DB has received competitive research funding from the National Heart Foundation Australia and from the Agency for Science, Technology and Research of the Singapore Government. He is co-inventor on a patent related to diagnostics submitted through the Genome Institute of Singapore.

Use of this content is subject to our disclaimer