Older people receiving daily aspirin-based antiplatelet treatment without routine proton-pump inhibitor (PPI) use are at higher and more sustained risk of major bleeding than younger patients.
Half of the major bleeding events in patients ages 75 or older were upper gastrointestinal. The estimated numbers needed to treat for routine PPI use to prevent major upper gastrointestinal bleed were low. The authors concluded that co-prescription should be encouraged.
Approximately 15% of strokes are hemorrhagic.
CT or MRI scans, with high sensitivity for intracerebral hemorrhage, are essential in diagnosis.
Treatments for intracerebral hemorrhage and ischemic stroke differ radically.
The primary treatment of hemorrhagic stroke involves supportive care and optimization of intracranial hemodynamics.
Surgical resection of intracerebral hematomas may be of benefit in select cases, but has yet to be demonstrated as effective in clinical trials. Newer minimally invasive surgical techniques are currently being investigated.
Study results show that patients in dedicated stroke units have improved survival and reduced disability at 1 year.
Stroke is an acute neurologic deficit caused by cerebrovascular etiology. It is further subdivided into ischemic stroke and hemorrhagic stroke. Ischemic stroke is lack of blood perfusion due to occlusion or critical stenosis of a cerebrospinal artery, and hemorrhagic stroke is due to rupture of a cerebrospinal artery, resulting in intraparenchymal, subarachnoid, and intraventricular hemorrhage. Intracerebral hemorrhage is further subdivided into primary and secondary etiology. Primary spontaneous intracerebral hemorrhage is defined as hemorrhage in the absence of vascular malformations or associated diseases. Secondary intracerebral hemorrhage is from an identifiable vascular malformation or as a complication of other medical or neurologic diseases that either impair coagulation or promote vascular rupture.
Clinical Associate of Neurology
Medical Director, Neuroscience ICU
Director, Neurocritical Care Education
Co-Director, Stroke Center
University of Chicago
FDG declares that he has no competing interests.
Neurocritical Care Fellow
Department of Neurology
University of Chicago
RCM declares that she has no competing interests.
Dr Fernando Goldenberg and Dr Raisa Martinez would like to gratefully acknowledge Dr Alejandro Hornik, Dr Eric E. Smith, and Dr T. Dion Fung, the previous contributors to this monograph. EES is an author of a number of references cited in this monograph. AH and TDF declare that they have no competing interests.
Lecturer in Neurology
Beth Israel Deaconess Medical Center
Division of Cerebrovascular/Stroke
LRC declares that he has no competing interests.
Centre Hospitalier Universitaire Vaudois (CHUV)
JM declares that he has no competing interests.
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