A human papilloma virus (HPV)-related malignancy, preventable by HPV vaccination, screening, and treatment of high-grade dysplasia.
Papanicolaou test (Pap smear) screening followed by colposcopy may diagnose pre-invasive disease.
Locally advanced disease may present with bleeding, discharge, pain, or obstructive uropathy.
Staging is clinical, and does not incorporate lymph node evaluation or imaging results, but increasingly uses MRI to evaluate local extent of disease, and PET to screen for nodal and distant metastases.
For microinvasive disease, treatment with conisation is recommended.
For early stage invasive disease, surgery is recommended.
For locally advanced disease, chemoradiotherapy is significantly superior to radiotherapy alone.
Cervical cancer is an HPV-related malignancy of the uterine cervical mucosa.
Medical Gynecologic Oncology
Division of Hematology Oncology
Massachusetts General Hospital
RTP is a paid participant in scientific advisory boards for Genentech/Roche. RTP is the author of a number of references cited in this monograph.
Department of Radiation Oncology
Brigham and Women’s Hospital
LJL declares that she has no competing interests.
Dr Richard T. Penson and Dr Larissa J. Lee would like to gratefully acknowledge Dr Neil S. Horowitz and Dr Anthony H. Russell, the previous contributors to this monograph. NSH and AHR declare that they have no competing interests.
Minimally Invasive Gynecologic Surgery
Magee Women's Hospital
University of Pittsburgh Medical Center
LY declares that she has no competing interests.
Consultant in Obstetrics & Gynaecology
Lead Clinician in Colposcopy
Imperial College Healthcare NHS Trust
DL declares that she has no competing interests.
Use of this content is subject to our disclaimer