Last reviewed: June 2020
Last updated: March  2020

Summary

Definition

History and exam

Key diagnostic factors

  • close contact with other infected individuals
  • bright red macular erythema of the bilateral cheeks with sparing of the nasal ridge and perioral areas
  • erythematous macules and papules evolving into lacy reticular erythema, most notable on the extremities
  • immunodeficiency

Other diagnostic factors

  • arthralgia/arthritis
  • prodrome (fever, headache, pharyngitis, coryza, abdominal pain)
  • symptoms of anemia

Risk factors

  • close contact with other infected individuals
  • immunodeficiency
  • age 6 to 10 years

Diagnostic investigations

Treatment algorithm

Contributors

Associate Professor of Dermatology & Child Health

Pediatric Dermatology

University of Missouri - Columbia

Columbia

MO

Disclosures

KLM declares that she has no competing interests.

Dr Kari L. Martin would like to gratefully acknowledge Dr Christine T. Lauren, Dr Jon Dyer, and Dr Jennifer Holman, the previous contributors to this topic. CTL, JD, and JH declare that they have no competing interests.

Peer reviewersVIEW ALL

Professor

Department of Pathology and Laboratory Medicine

Children's and Women's Health Centre of British Columbia

Vancouver

Canada

Disclosures

NC declares that he has no competing interests.

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