References

Key articles

Kelley AS, Morrison RS. Palliative care for the seriously ill. N Engl J Med. 2015 Aug 20;373(8):747-55.Full text  Abstract

Bakitas MA, Tosteson TD, Li Z, et al. Early versus delayed initiation of concurrent palliative oncology care: patient outcomes in the ENABLE III randomized controlled trial. J Clin Oncol. 2015 May 1;33(13):1438-45. Abstract

Bernacki RE, Block SD; American College of Physicians High Value Care Task Force. Communication about serious illness care goals: a review and synthesis of best practices. JAMA Intern Med. 2014 Dec;174(12):1994-2003. Abstract

Del Fabbro E, Dalal S, Bruera E. Symptom control in palliative care - part II: cachexia/anorexia and fatigue. J Palliat Med. 2006 Apr;9(2):409-21. Abstract

Finnerup NB, Attal N, Haroutounian S, et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol. 2015 Feb;14(2):162-73. Abstract

Quigley C. The role of opioids in cancer pain. BMJ. 2005 Oct 8;331(7520):825-9. Abstract

National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: adult cancer pain [internet publication].Full text

Caraceni A, Hanks G, Kaasa S, et al; European Palliative Care Research Collaborative (EPCRC), European Association for Palliative Care (EAPC). Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC. Lancet Oncol. 2012 Feb;13(2):e58-68. Abstract

Paice JA, Portenoy R, Lacchetti C, et al. Management of chronic pain in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol. 2016 Sep 20;34(27):3325-45.Full text  Abstract

Li M, Fitzgerald P, Rodin G. Evidence-based treatment of depression in patients with cancer. J Clin Oncol. 2012 Apr 10;30(11):1187-96. Abstract

Andersen BL, DeRubeis RJ, Berman BS, et al; American Society of Clinical Oncology. Screening, assessment, and care of anxiety and depressive symptoms in adults with cancer: an American Society of Clinical Oncology guideline adaptation. J Clin Oncol. 2014 May 20;32(15):1605-19.Full text  Abstract

Chittenden EH, Clark ST, Pantilat SZ. Discussing resuscitation preferences with patients: challenges and rewards. J Hosp Med. 2006 Jul;1(4):231-40. Abstract

Fischberg D, Bull J, Casarett D, et al; AAHPM Choosing Wisely Task Force. Five things physicians and patients should question in hospice and palliative medicine. J Pain Symptom Manage. 2013 Mar;45(3):595-605.Full text  Abstract

National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: palliative care [internet publication].Full text

Ferrell BR, Temel JS, Temin S, et al. Integration of palliative care into standard oncology care: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol. 2017 Jan;35(1):96-112.Full text  Abstract

Bosslet GT, Pope TM, Rubenfeld GD, et al; American Thoracic Society/ American Association for Critical Care Nurses/ American College of Chest Physicians/ European Society for Intensive Care Medicine/ Society of Critical Care Medicine. An official ATS/AACN/ACCP/ESICM/SCCM policy statement: responding to requests for potentially inappropriate treatments in intensive care units. Am J Respir Crit Care Med. 2015 Jun 1;191(11):1318-30. Abstract

Reference articles

1. Kelley AS, Morrison RS. Palliative care for the seriously ill. N Engl J Med. 2015 Aug 20;373(8):747-55.Full text  Abstract

2. Center to Advance Palliative Care. Policy Matters [internet publication].Full text

3. Department of Health and Human Services. Medicare and Medicaid programs: hospice conditions of participation; final rule. Fed Regist. 2008 Jun 5;73(109):32087-220.Full text  Abstract

4. Parikh RB, Kirch RA, Smith TJ, et al. Early specialty palliative care - translating data on oncology into practice. New Engl J Med. 2013 Dec 12;369(24):2347-51.Full text  Abstract

5. Morrison RS, Meier DE. Palliative care. N Engl J Med. 2004 Jun 17;350(25):2582-90. Abstract

6. Centers for Medicare and Medicaid Services Manual System. Medicare general information, eligibility, and entitlement: physician certification and recertification of services manual changes. April 2011 [internet publication].Full text

7. Murphy SL, Xu JQ, Kochanek KD, Arias E. Mortality in the United States, 2017. NCHS Data Brief, no 328. Hyattsville, MD: National Center for Health Statistics. 2018 [internet publication].Full text

8. World Health Organization. Top 10 causes of death. January 2017 [internet publication].Full text

9. United Nations. World population ageing 2019. 2019 [internet publication].Full text

10. Naqvi F, Cervo F, Fields S. Evidence-based review of interventions to improve palliation of pain, dyspnea, depression. Geriatrics. 2009 Aug;64(8):8-10, 12-4. Abstract

11. United Nations Programme on Ageing. The Madrid international plan of action on ageing. New York; UN Department of Economics and Social Affairs: 2002 [internet publication].Full text

12. A controlled trial to improve care for seriously ill hospitalized patients: The Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments (SUPPORT). The SUPPORT Principal Investigators. JAMA. 1995 Nov 22-29;274(20):1591-8. Abstract

13. Higginson IJ, Sen-Gupta GJA. Place of care in advanced cancer: a qualitative systematic literature review of patient preferences. J Palliat Med. 2000;3(3):287-300. Abstract

14. Teno JM, Freedman VA, Kasper JD, et al. Is care for the dying improving in the United States? J Palliat Med. 2015 Aug;18(8):662-6. Abstract

15. Carson SS, Cox CE, Wallenstein S, et al. Effect of palliative care-led meetings for families of patients with chronic critical illness: a randomized clinical trial. JAMA. 2016 Jul 5;316(1):51-62.Full text  Abstract

16. Institute of Medicine. Dying in America: improving quality and honoring individual preferences near the end of life. National Academies Press, Washington, DC; 2014.

17. Ravakhah K, Chideme-Munodawafa A, Nakagawa S. Financial outcomes of palliative care services in an intensive care unit. J Palliat Med. 2010 Jan;13(1):7. Abstract

18. Penrod JD, Deb P, Dellenbaugh C, et al. Hospital-based palliative care consultation: effects on hospital cost. J Palliat Med. 2010 Aug;13(8):973-9. Abstract

19. Morrison RS, Penrod JD, Cassel JB, et al. Cost savings associated with US hospital palliative care consultation programs. Arch Intern Med. 2008 Sep 8;168(16):1783-90.Full text  Abstract

20. Khandelwal N, Kross EK, Engelberg RA, et al. Estimating the effect of palliative care interventions and advance care planning on ICU utilization: a systematic review. Crit Care Med. 2015 May;43(5):1102-1.Full text  Abstract

21. Gade G, Venohr I, Conner D, et al. Impact of an inpatient palliative care team: a randomized controlled trial. J Palliat Med. 2008 Mar;11(2):180-90. Abstract

22. Ciemins EL, Blum L, Nunley M, et al. The economic and clinical impact of an inpatient palliative care consultation service: a multifaceted approach. J Palliat Med. 2007 Dec;10(6):1347-55. Abstract

23. Bendaly EA, Groves J, Juliar B, et al. Financial impact of palliative care consultation in a public hospital. J Palliat Med. 2008 Dec;11(10):1304-8. Abstract

24. Bainbridge D, Seow H, Sussman J. Common components of efficacious in-home end-of-life care programs: a review of systematic reviews. J Am Geriatr Soc. 2016 Mar;64(3):632-9. Abstract

25. Curtis JR, Treece PD, Nielsen EL, et al. Randomized trial of communication facilitators to reduce family distress and intensity of end-of-life care. Am J Respir Crit Care Med. 2016 Jan 15;193(2):154-62.Full text  Abstract

26. Khandelwal N, Long AC, Lee RY, et al. Pragmatic methods to avoid intensive care unit admission when it does not align with patient and family goals. Lancet Respir Med. 2019 Jul;7(7):613-25.Full text  Abstract

27. Turnbull AE, Bosslet GT, Kross EK. Aligning use of intensive care with patient values in the USA: past, present, and future. Lancet Respir Med. 2019 Jul;7(7):626-38.Full text  Abstract

28. Anesi GL, Admon AJ, Halpern SD, et al. Understanding irresponsible use of intensive care unit resources in the USA. Lancet Respir Med. 2019 Jul;7(7):605-12.Full text  Abstract

29. Lilley EJ, Khan KT, Johnston FM, et al. Palliative care interventions for surgical patients: a systematic review. JAMA Surg. 2016 Feb;151(2):172-83. Abstract

30. Bakitas M, Lyons KD, Hegel MT, et al. Effects of a palliative care intervention on clinical outcomes in patients with advanced cancer: the Project ENABLE II randomized controlled trial. JAMA. 2009 Aug 19;302(7):741-9.Full text  Abstract

31. Gomes B, Calanzani N, Curiale V, et al. Effectiveness and cost-effectiveness of home palliative care services for adults with advanced illness and their caregivers. Cochrane Database Syst Rev. 2013 Jun 6;(6):CD007760.Full text  Abstract

32. Shepperd S, Gonçalves-Bradley DC, Straus SE, et al. Hospital at home: home-based end-of-life care. Cochrane Database Syst Rev. 2016 Feb 18;2(2):CD009231.Full text  Abstract

33. Agency for Healthcare Research and Quality. Home-based primary care interventions. 2016 [internet publication].Full text

34. Temel JS, Greer JA, Muzikansky A, et al. Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med. 2010 Aug 19;363(8):733-42. Abstract

35. Bakitas MA, Tosteson TD, Li Z, et al. Early versus delayed initiation of concurrent palliative oncology care: patient outcomes in the ENABLE III randomized controlled trial. J Clin Oncol. 2015 May 1;33(13):1438-45. Abstract

36. Vanbutsele G, Pardon K, Van Belle S, et al. Effect of early and systematic integration of palliative care in patients with advanced cancer: a randomised controlled trial. Lancet Oncol. 2018 Mar;19(3):394-404.Full text  Abstract

37. Peppercorn JM, Smith TJ, Helft PR, et al. American Society of Clinical Oncology statement: toward individualized care for patients with advanced cancer. J Clin Oncol. 2011 Feb 20;29(6):755-60.Full text  Abstract

38. Glare PA. Early implementation of palliative care can improve patient outcomes. J Natl Compr Canc Netw. 2013 Mar;11 Suppl 1:S3-9.Full text  Abstract

39. Joint Commission on Accreditation of Health Care Organizations. Approved: certification option for home care organizations providing community-based palliative care. Jt Comm Perspect. 2016 Mar;36(3):6.Full text  Abstract

40. Joint Commission on Accreditation of Health Care Organizations. Clarification: Eligibility for advanced certification for palliative care. Jt Comm Perspect. 2016 Mar;36(3):6. Abstract

41. Christakis NA, Lamont EB. Extent and determinants of error in doctors' prognoses in terminally ill patients: prospective cohort study. BMJ. 2000 Feb 19;320(7233):469-72.Full text  Abstract

42. Finlayson CS, Chen YT, Fu MR. The impact of patients' awareness of disease status on treatment preferences and quality of life among patients with metastatic cancer: a systematic review from 1997-2014. J Palliat Med. 2015 Feb;18(2):176-86. Abstract

43. Weeks JC, Cook EF, O'Day SJ, et al. Relationship between cancer patients' predictions of prognosis and their treatment preferences. JAMA. 1998 Jun 3;279(21):1709-14.Full text  Abstract

44. Institute for Clinical Systems Improvement. Health care guideline: palliative care. November 2013 [internet publication].Full text

45. Moss AH, Lunney JR, Culp S, et al. Prognostic significance of the "surprise" question in cancer patients. J Palliat Med. 2010 Jul;13(7):837-40. Abstract

46. Moroni M, Zocchi D, Bolognesi D, et al. The 'surprise' question in advanced cancer patients: a prospective study among general practitioners. Palliat Med. 2014 Jul;28(7):959-64. Abstract

47. Downar J, Goldman R, Pinto R, et al. The “surprise question” for predicting death in seriously ill patients: a systematic review and meta-analysis. CMAJ. 2017 Apr 3;189(13):E484-93.Full text  Abstract

48. Education for Physicians on End-of-life Care (EPEC). Trainer's guide, module 2. Princeton, NJ: The Robert Wood Johnson Foundation; 1999.

49. Knaus WA, Harrell FE, Lynn J, et al. The SUPPORT prognostic model: objective estimates of survival for seriously ill hospitalized adults. Ann Intern Med. 1995 Feb 1;122(3):191-203. Abstract

50. Lau F, Downing GM, Lesperance M, et al. Use of palliative performance scale in end-of-life prognostication. J Palliat Med. 2006 Oct;9(5):1066-75. Abstract

51. Olajide O, Hanson L, Usher BM, et al. Validation of the palliative performance scale in the acute tertiary care hospital setting. J Palliat Med. 2007 Feb;10(1):111-7. Abstract

52. Seow H, Barbera L, Dudgeon D, et al. The association of the palliative performance scale and hazard of death in an ambulatory cancer population. J Palliat Med. 2013 Feb;16(2):156-62. Abstract

53. Glare P, Virik K. Independent prospective validation of the PaP score in terminally ill patients referred to a hospital-based palliative medicine consultation service. J Pain Symptom Manage. 2001 Nov;22(5):891-8. Abstract

54. Glare P, Eychmueller S, Virik K, et al. The use of the palliative prognostic score in patients with diagnoses other than cancer. J Pain Symptom Manage. 2003 Oct;26(4):883-5. Abstract

55. Inouye SK, Peduzzi PN, Robison JT, et al. Importance of functional measures in predicting mortality among older hospitalized patients. JAMA. 1998 Apr 15;279(15):1187-93.Full text  Abstract

56. Fischer SM, Gozansky WS, Sauaia A, et al. A practical tool to identify patients who may benefit from a palliative approach: the CARING criteria. J Pain Symptom Manage. 1998 Apr 15;279(15):1187-93. Abstract

57. Youngwerth J, Min SJ, Statland B, et al. Caring about prognosis: a validation study of the caring criteria to identify hospitalized patients at high risk for death at 1 year. J Hosp Med. 2013 Dec;8(12):696-701. Abstract

58. Glare PA, Sinclair CT. Palliative medicine review: prognostication. J Palliat Med. 2008 Jan-Feb;11(1):84-103. Abstract

59. Bernacki RE, Block SD; American College of Physicians High Value Care Task Force. Communication about serious illness care goals: a review and synthesis of best practices. JAMA Intern Med. 2014 Dec;174(12):1994-2003. Abstract

60. Education for Physicians on End-of-life Care (EPEC). Trainer's guide, module 7. Princeton, NJ: The Robert Wood Johnson Foundation; 1999.

61. Kaldjian LC, Curtis AE, Shinkunas LA, et al. Goals of care toward the end of life: a structured literature review. Am J Hosp Palliat Care. 2014 Dec;174(12):1994-2003. Abstract

62. Johnston B, Larkin P, Connolly M, et al. Dignity-conserving care in palliative care settings: an integrative review. J Clin Nurs. 2015 Jul;24(13-14):1743-72. Abstract

63. Education for Physicians on End-of-life Care (EPEC). Trainer's guide, module 3. Princeton, NJ: The Robert Wood Johnson Foundation; 1999.

64. Murray SA, Kendall M, Boyd K, et al. Illness trajectories and palliative care. BMJ. 2005 Apr 30;330(7498):1007-11. Abstract

65. Janssen DJ, Spruit MA, Wouters EF, et al. Daily symptom burden in end-stage chronic organ failure: a systematic review. Palliat Med. 2008 Dec;22(8):938-48. Abstract

66. Porter S, Knight CF, Schonwetter RS. Pocket guide to hospice/palliative medicine. Glenview, IL: American Academy of Hospice and Palliative Medicine; 2003:57-97.

67. Hjermstad MJ, Gibbins J, Haugen DF, et al. Pain assessment tools in palliative care: an urgent need for consensus. Palliat Med. 2008 Dec;22(8):895-903. Abstract

68. Youngwerth J, Johnson D. Palliative care: management of common physical and psychological symptoms. In: Glasheen JJ, ed. Hospital medicine secrets. Philadelphia, PA: Elsevier; 2007:612-8.

69. Thomas JR, von Gunten CF. Clinical management of dyspnoea. Lancet Oncol. 2002 Apr;3(4):223-8. Abstract

70. Panchal SJ, Muller-Schwefe J, Wurzelmann JI. Opioid-induced bowel dysfunction: prevalence, pathophysiology and burden. Int J Clin Pract. 2007 Jul;61(7):1181-7.Full text  Abstract

71. Miovic M, Block S. Psychiatric disorders in advanced cancer. Cancer. 2007 Oct 15;110(8):1665-76.Full text  Abstract

72. Lloyd-Williams M, Spiller J, Ward J. Which depression screening tools should be used in palliative care? Palliat Med. 2003 Jan;17(1):40-3. Abstract

73. Levis B, Benedetti A, Thombs BD, et al. Accuracy of Patient Health Questionnaire-9 (PHQ-9) for screening to detect major depression: individual participant data meta-analysis. BMJ. 2019 Apr 9;365:1476.Full text  Abstract

74. Horne-Thompson A, Grocke D. The effect of music therapy on anxiety in patients who are terminally ill. J Palliat Med. 2008 May;11(4):582-90. Abstract

75. Yennurajalingam S, Bruera E. Palliative management of fatigue at the close of life. JAMA. 2007 Jan 17;297(3):295-304. Abstract

76. Del Fabbro E, Dalal S, Bruera E. Symptom control in palliative care - part II: cachexia/anorexia and fatigue. J Palliat Med. 2006 Apr;9(2):409-21. Abstract

77. Yavuzsen T, Davis MP, Walsh D, et al. Systematic review of the treatment of cancer-associated anorexia and weight loss. J Clin Oncol. 2005 Nov 20;23(33):8500-11. Abstract

78. Vaurio LE, Sands LP, Wang Y, et al. Postoperative delirium: the importance of pain and pain management. Anesth Analg. 2006 Apr;102(4):1267-73.Full text  Abstract

79. Morrison RS, Magaziner J, Gilbert M, et al. Relationship between pain and opioid analgesics on the development of delirium following hip fractures. J Gerontol A Biol Sci Med Sci. 2003 Jan;58(1):76-81. Abstract

80. Salluh JI, Wang H, Schneider EB, et al. Outcome of delirium in critically ill patients: systematic review and meta-analysis. BMJ. 2015 Jun 3;350:h2538.Full text  Abstract

81. Hosie A, Agar M, Lobb E, et al. Improving delirium recognition and assessment for people receiving inpatient palliative care: a mixed methods meta-synthesis. Int J Nurs Stud. 2017 Oct;75:123-9. Abstract

82. Solano JP. A comparison of symptom prevalence in far advanced cancer, AIDS, heart disease, chronic obstructive pulmonary disease and renal disease. J Pain Symptom Manage. 2006 Jan;31(1):58-69. Abstract

83. Morin L, Todd A, Barclay S, et al. Preventive drugs in the last year of life of older adults with cancer: Is there room for deprescribing? Cancer. 2019 Jul 1;125(13):2309-17.Full text  Abstract

84. Knudsen AK, Aass N, Fainsinger R, et al. Classification of pain in cancer patients: a systematic literature review. Palliat Med. 2009 Jun;23(4):295-308. Abstract

85. AGS Panel on Persistent Pain in Older Persons. The management of persistent pain in older persons. J Am Geriatr Soc. 2002 Jun;50(6 Suppl):S205-24. Abstract

86. Furlan AD, Sandoval JA, Mailis-Gagnon A, et al. Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects. CMAJ. 2006 May 23;174(11):1589-94.Full text  Abstract

87. Kalso E, Edwards JE, Moore RA, et al. Opioids in chronic non-cancer pain: a systematic review of efficacy and safety. Pain. 2004 Dec;112(3):372-80. Abstract

88. Selecky PA, Eliasson Col. AH, Hall RI, et al. Palliative and end-of-life care for patients with cardiopulmonary diseases: American College of Chest Physicians position statement. Chest. 2005 Nov;128(5):3599-610. Abstract

89. Busse JW, Wang L, Kamaleldin M, et al. Opioids for Chronic Noncancer Pain: A Systematic Review and Meta-analysis. JAMA. 2018 Dec 18;320(23):2448-60.Full text  Abstract

90. Finnerup NB, Attal N, Haroutounian S, et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol. 2015 Feb;14(2):162-73. Abstract

91. McNicol ED, Midbari A, Eisenberg E. Opioids for neuropathic pain. Cochrane Database Syst Rev. 2013 Aug 29;2013(8):CD006146.Full text  Abstract

92. Quigley C. The role of opioids in cancer pain. BMJ. 2005 Oct 8;331(7520):825-9. Abstract

93. Bardia A, Barton DL, Prokop LJ, et al. Efficacy of complementary and alternative medicine therapies in relieving cancer pain: a systematic review. J Clin Oncol. 2006 Dec 1;24(34):5457-64. Abstract

94. Bradt J, Dileo C, Magill L, et al. Music interventions for improving psychological and physical outcomes in cancer patients. Cochrane Database Syst Rev. 2016 Aug 15;(8):CD006911.Full text  Abstract

95. Dalton JA, Keefe FJ, Carlson J, et al. Tailoring cognitive-behavioral treatment for cancer pain. Pain Manag Nurs. 2004 Mar;5(1):3-18. Abstract

96. Ernst E. Massage therapy for cancer palliation and supportive care: a systematic review of randomised clinical trials. Support Care Cancer. 2009 Apr;17(4):333-7. Abstract

97. Given C, Given B, Rahbar M, et al. Effect of a cognitive behavioral intervention on reducing symptom severity during chemotherapy. J Clin Oncol. 2004 Feb 1;22(3):507-16. Abstract

98. Guidelines and Audit Implementation Network. General palliative care guidelines for the management of pain at the end of life in adult patients. February 2011 [internet publication].Full text

99. Gutgsell KJ, Schluchter M, Margevicius S, et al. Music therapy reduces pain in palliative care patients: a randomized controlled trial. J Pain Symptom Manage. 2013 May;45(5):822-31. Abstract

100. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: adult cancer pain [internet publication].Full text

101. Wilkinson S, Lockhart E, Gambles M, et al. Reflexology for symptom relief in patients with cancer. Cancer Nurs. 2008 Sep-Oct;31(5):354-60. Abstract

102. Caraceni A, Hanks G, Kaasa S, et al; European Palliative Care Research Collaborative (EPCRC), European Association for Palliative Care (EAPC). Use of opioid analgesics in the treatment of cancer pain: evidence-based recommendations from the EAPC. Lancet Oncol. 2012 Feb;13(2):e58-68. Abstract

103. Levy MH. Pharmacologic treatment of cancer pain. N Engl J Med. 1996 Oct 10;335(15):1124-32. Abstract

104. Paice JA, Portenoy R, Lacchetti C, et al. Management of chronic pain in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol. 2016 Sep 20;34(27):3325-45.Full text  Abstract

105. Caraceni A, Pigni A, Brunelli C. Is oral morphine still the first choice opioid for moderate to severe cancer pain? A systematic review within the European Palliative Care Research Collaborative guidelines project. Palliat Med. 2011 Jul;25(5):402-9. Abstract

106. King SJ, Reid C, Forbes K, et al. A systematic review of oxycodone in the management of cancer pain. Palliat Med. 2011 Jul;25(5):454-70 Abstract

107. Riley J, Branford R, Droney J, et al. Morphine or oxycodone for cancer-related pain? A randomized, open-label, controlled trial. J Pain Symptom Manage. 2015 Feb;49(2):161-72. Abstract

108. Schmidt-Hansen M, Bennett MI, Hilgart J. Oxycodone for cancer pain in adult patients. JAMA. 2015 Sep 22-29;314(12):1282-3. Abstract

109. Wiffen PJ, Wee B, Moore RA. Oral morphine for cancer pain. Cochrane Database Syst Rev. 2016 Apr 22;4(4):CD003868.Full text  Abstract

110. LeBon B, Zeppetella G, Higginson IJ. Effectiveness of topical administration of opioids in palliative care: a systematic review. J Pain Symptom Manage. 2009 May;37(5):913-7. Abstract

111. Flemming K. The use of morphine to treat cancer-related pain: a synthesis of quantitative and qualitative research. J Pain Symptom Manage. 2010 Jan;39(1):139-54. Abstract

112. Vignaroli E, Bennett MI, Nekolaichuk C, et al. Strategic pain management: the identification and development of the IAHPC opioid essential prescription package. J Palliat Med. 2012 Feb;15(2):186-91.Full text  Abstract

113. Klepstad P, Kaasa S, Borchgrevink PC. Starting step III opioids for moderate to severe pain in cancer patients: dose titration: a systematic review. Palliat Med. 2011 Jul;25(5):424-30. Abstract

114. Education for Physicians on End-of-life Care (EPEC). Trainer's guide, module 4. Princeton, NJ: The Robert Wood Johnson Foundation; 1999.

115. Collaborative for REMS Education. Extended release/long acting opioids: achieving safe use while improving patient care. Collaborative for REMS Education CO*RE Seller: CORE Collaboration for REMS Education; 2013.

116. Ballantyne JC, Mao J. Opioid therapy for chronic pain. N Engl J Med. 2003 Nov 13;349(20):1943-53. Abstract

117. McPherson ML, Walker KA, Davis MP, et al. Safe and Appropriate Use of Methadone in Hospice and Palliative Care: Expert Consensus White Paper. J Pain Symptom Manage. 2019 Mar;57(3):635-645.e4.Full text  Abstract

118. King S, Forbes K, Hanks GW, et al. A systematic review of the use of opioid medication for those with moderate to severe cancer pain and renal impairment: a European Palliative Care Research Collaborative opioid guidelines project. Palliat Med. 2011 Jul;25(5):525-52. Abstract

119. O'Connor AB, Dworkin RH. Treatment of neuropathic pain: an overview of recent guidelines. Am J Med. 2009 Oct;122(10 Suppl):S22-32. Abstract

120. Kvale PA, Selecky PA, Prakash UB. Palliative care in lung cancer: ACCP evidence-based clinical practice guidelines. Chest. 2007 Sep;132(3 Suppl):368S-403S. Abstract

121. Smyth CE, Jarvis V, Poulin P. Brief review: neuraxial analgesia in refractory malignant pain. Can J Anaesth. 2014 Feb;61(2):141-53. Abstract

122. Angst MS, Clark JD. Opioid-induced hyperalgesia. Anesthesiology. 2006 Mar;104(3):570-87. Abstract

123. Mercadante S, Bruera E. Opioid switching: a systematic and critical review. Cancer Treat Rev. 2006 Jun;32(4):304-15. Abstract

124. Mercadante S. Opioid rotation for cancer pain. Cancer. 1999 Nov 1;86(9):1856-66. Abstract

125. Gilron I, Bailey JM, Tu D, et al. Morphine, gabapentin, or their combination for neuropathic pain. N Engl J Med. 2005 Mar 31;352(13):1324-34.Full text  Abstract

126. Smith EM, Pang H, Cirrincione C, et al; Alliance for Clinical Trials in Oncology. Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial. JAMA. 2013 Apr 3;309(13):1359-67. Abstract

127. Bauman G, Charette M, Reid R, et al. Radiopharmaceuticals for the palliation of painful metastasis - a systematic review. Radiother Oncol. 2005 Jun;75(3):258-70. Abstract

128. Serafini AN. Therapy of metastatic bone pain. J Nucl Med. 2001 Jun;42(6):895-906.Full text  Abstract

129. Macherey S, Monsef I, Jahn F, et al. Bisphosphonates for advanced prostate cancer. Cochrane Database Syst Rev. 2017 Dec 26;(12):CD006250.Full text  Abstract

130. Wong R, Wiffen PJ. Bisphosphonates for the relief of pain secondary to bone metastasis. Cochrane Database Syst Rev. 2002;2002(2):CD002068.Full text  Abstract

131. O'Carrigan B, Wong MH, Willson ML, et al. Bisphosphonates and other bone agents for breast cancer. Cochrane Database Syst Rev. 2017 Oct 30;10:CD003474.Full text  Abstract

132. Sze WM, Shelley M, Held I, et al. Palliation of metastatic bone pain: single fraction versus multifraction radiotherapy. Cochrane Database Syst Rev. 2004;2002(2):CD004721.Full text  Abstract

133. Lutz S, Balboni T, Jones J, et al. Palliative radiation therapy for bone metastases: Update of an ASTRO Evidence-Based Guideline. Pract Radiat Oncol. 2017 Jan - Feb;7(1):4-12.Full text  Abstract

134. Martinez-Zapata MJ, Roqué i Figuls M, Alonso-Coello P, et al. Calcitonin for metastatic bone pain. Cochrane Database Syst Rev. 2006 Jul 19;(3):CD003223. Abstract

135. Fallon M, Hoskin PJ, Colvin LA, et al. Randomized double-blind trial of pregabalin versus placebo in conjunction with palliative radiotherapy for cancer-induced bone pain. J Clin Oncol. 2016 Feb 20;34(6):550-6.Full text  Abstract

136. Sze WM, Shelley M, Held I, et al. Palliation of metastatic bone pain: single fraction versus multifraction radiotherapy. Clin Oncol (R Coll Radiol). 2003 Sep;15(6):345-52. Abstract

137. Chow E, Harris K, Fan G, et al. Palliative radiotherapy trials for bone metastases: a systematic review. J Clin Oncol. 2007 Apr 10;25(11):1423-36. Abstract

138. Roqué i Figuls M, Martinez-Zapata MJ, Scott-Brown M, et al. Radioisotopes for metastatic bone pain. Cochrane Database Syst Rev. 2011 Jul 6;(7):CD003347.Full text  Abstract

139. Meeuse JJ, van der Linden YM, van Tienhoven G, et al. Efficacy of radiotherapy for painful bone metastases during the last 12 weeks of life: results from the Dutch Bone Metastasis Study. Cancer. 2010 Jun 1;116(11):2716-25.Full text  Abstract

140. Dennis K, Makhani L, Zeng L, et al. Single fraction conventional external beam radiation therapy for bone metastases: a systematic review of randomised controlled trials. Radiother Oncol. 2013 Jan;106(1):5-14. Abstract

141. Chow E, Zeng L, Salvo N, et al. Update on the systematic review of palliative radiotherapy trials for bone metastases. Clin Oncol (R Coll Radiol). 2012 Mar;24(2):112-24. Abstract

142. Lorenz KA, Lynn J, Dy SM, et al. Evidence for improving palliative care at the end of life: a systematic review. Ann Intern Med. 2008 Jan 15;148(2):147-59. Abstract

143. Qaseem A, Snow V, Shekelle P, et al. Evidence-based interventions to improve the palliative care of pain, dyspnea, and depression at the end of life: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2008 Jan 15;148(2):141-6.Full text  Abstract

144. Hui D, Bohlke K, Bao T, et al. Management of Dyspnea in Advanced Cancer: ASCO Guideline. J Clin Oncol. 2021 Apr 20;39(12):1389-1411. Abstract

145. Kamal AH, Maguire JM, Wheeler JL, et al. Dyspnea review for the palliative care professional: treatment goals and therapeutic options. J Palliat Med. 2012 Jan;15(1):106-14.Full text  Abstract

146. Johnson MJ, Hui D, Currow DC. Opioids, exertion, and dyspnea: a review of the evidence. Am J Hosp Palliat Care. 2016 Mar;33(2):194-200. Abstract

147. Jennings AL, Davies AN, Higgins JP, et al. A systematic review of the use of opioids in the management of dyspnoea. Thorax. 2002 Nov;57(11):939-44.Full text  Abstract

148. Viola R, Kiteley C, Lloyd NS, et al. The management of dyspnea in cancer patients: a systematic review. Support Care Cancer. 2008 Apr;16(4):329-37. Abstract

149. Ben-Aharon I, Gafter-Gvili A, Paul A, et al. Interventions for alleviating cancer-related dyspnea: a systematic review. J Clin Oncol. 2008 May 10;26(14):2396-404. Abstract

150. Barnes H, McDonald J, Smallwood N, et al. Opioids for the palliation of refractory breathlessness in adults with advanced disease and terminal illness. Cochrane Database Syst Rev. 2016 Mar 31;3(3):CD011008.Full text  Abstract

151. Polosa R, Simidchiev A, Walters EH. Nebulised morphine for severe interstitial lung disease. Cochrane Database Syst Rev. 2002 Jul 22;(3):CD002872. Abstract

152. Abernethy AP, Currow DC, Frith P, et al. Randomised, double blind, placebo controlled crossover trial of sustained release morphine for the management of refractory dyspnoea. BMJ. 2003 Sep 6;327(7414):523-8.Full text  Abstract

153. Booth S, Anderson H, Swannick M, et al. The use of oxygen in the palliation of breathlessness. A report of the expert working group of the Scientific Committee of the Association of Palliative Medicine. Respir Med. 2004 Jan;98(1):66-77. Abstract

154. Philip J, Gold M, Milner A, et al. A randomized, double-blind, crossover trial of the effect of oxygen on dyspnea in patients with advanced cancer. J Pain Symptom Manage. 2006 Dec;32(6):541-50. Abstract

155. Abernethy AP, McDonald CF, Frith PA, et al. Effect of palliative oxygen versus room air in relief of breathlessness in patients with refractory dyspnoea: a double-blind, randomised controlled trial. Lancet. 2010 Sep 4;376(9743):784-93.Full text  Abstract

156. Bruera E, Sweeney C, Willey J, et al. A randomized controlled trial of supplemental oxygen versus air in cancer patients with dyspnea. Palliat Med. 2003 Dec;17(8):659-63. Abstract

157. Ameer F, Carson KV, Usmani ZA, et al. Ambulatory oxygen for people with chronic obstructive pulmonary disease who are not hypoxaemic at rest. Cochrane Database Syst Rev. 2014 Jun 24;2014(6):CD000238.Full text  Abstract

158. Hui D, Kilgore K, Frisbee-Hume S, et al. Dexamethasone for dyspnea in cancer patients: a pilot double-blind, randomized, controlled trial. J Pain Symptom Manage. 2016 Jul;52(1):8-16.e1. Abstract

159. Man GC, Hsu K, Sproule BJ. Effect of alprazolam on exercise and dyspnea in patients with chronic obstructive pulmonary disease. Chest. 1986 Dec;90(6):832-6. Abstract

160. Simon ST, Higginson IJ, Booth S, et al. Benzodiazepines for the relief of breathlessness in advanced malignant and non-malignant diseases in adults. Cochrane Database Syst Rev. 2016 Oct 20;10(10):CD007354.Full text  Abstract

161. Navigante AH, Cerchietti LCA, Castro MA, et al. Midazolam as adjunct therapy to morphine in the alleviation of severe dyspnea perception in patients with advanced cancer. J Pain Symptom Manage. 2006 Jan;31(1):38-47. Abstract

162. Bausewein C, Booth S, Gysels M, et al. Non-pharmacological interventions for breathlessness in advanced stages of malignant and non-malignant diseases. Cochrane Database Syst Rev. 2008 Apr 16;(2):CD005623.Full text  Abstract

163. Bolzani A, Rolser SM, et al. Physical interventions for breathlessness in adults with advanced diseases. Cochrane Database Syst Rev. 2017 Jun; 2017(6): CD012684Full text

164. Chan JD, Treece PD, Engelberg RA, et al. Narcotic and benzodiazepine use after withdrawal of life support: association with time to death? Chest. 2004 Jul;126(1):286-93. Abstract

165. Clemens KE, Quednau I, Klaschik E. Is there a higher risk of respiratory depression in opioid-naive palliative care patients during symptomatic therapy of dyspnea with strong opioids? J Palliat Med. 2008 Mar;11(2):204-16. Abstract

166. Mahler DA, Selecky PA, Harrod CG, et al. American College of Chest Physicians consensus statement on the management of dyspnea in patients with advanced lung or heart disease. Chest. 2010 Mar;137(3):674-91.Full text  Abstract

167. Goodheart CR, Leavitt SB. Pain treatment topics: managing opioid-induced constipation in ambulatory-care patients. August 2006 [internet publication].Full text

168. Larkin PJ, Sykes NP, Centeno C, et al. The management of constipation in palliative care: clinical practice recommendations. Palliat Med. 2008 Oct;22(7):796-807. Abstract

169. Librach SL, Bouvette M, De Angelis C, et al. Consensus recommendations for the management of constipation in patients with advanced, progressive illness. J Pain Symptom Manage. 2010 Nov;40(5):761-73. Abstract

170. Candy B, Jones L, Larkin PJ, et al. Laxatives for the management of constipation in people receiving palliative care. Cochrane Database Syst Rev. 2015 May 13;2015(5):CD003448.Full text  Abstract

171. Education for Physicians on End-of-life Care (EPEC). Trainer's guide, module 10. Princeton, NJ: The Robert Wood Johnson Foundation; 1999.

172. Klaschik E, Nauck F, Ostgathe C. Constipation - modern laxative therapy. Support Care Cancer. 2003 Nov;11(11):679-85. Abstract

173. Wood GJ, Shega JW, Lynch B, et al. Management of intractable nausea and vomiting in patients at the end of life. JAMA. 2007 Sep 12;298(10):1196-207. Abstract

174. Hawley PH, Byeon JJ. A comparison of sennosides-based bowel protocols with and without docusate in hospitalized patients with cancer. J Palliat Med. 2008 May;11(4):575-81. Abstract

175. Tarumi Y, Wilson MP, Szafran O, et al. Randomized, double-blind, placebo-controlled trial of oral docusate in the management of constipation in hospice patients. J Pain Symptom Manage. 2013 Jan;45(1):2-13.Full text  Abstract

176. Hurdon V, Viola R, Schroder C. How useful is docusate in patients at risk for constipation? A systematic review of the evidence in the chronically ill. J Pain Symptom Manage. 2000 Feb;19(2):130-6. Abstract

177. Thomas J, Karver S, Cooney GA, et al. Methylnaltrexone for opioid-induced constipation in advanced illness. N Engl J Med. 2008 May 29;358(22):2332-43.Full text  Abstract

178. Chamberlain BH, Cross K, Winston JL, et al. Methylnaltrexone treatment of opioid-induced constipation in patients with advanced illness. J Pain Symptom Manage. 2009 Nov;38(5):683-90. Abstract

179. Ndefo UA, Erowele GI. Focus on methylnaltrexone: a selective mu-opioid receptor antagonist for the treatment of opioid-induced constipation. J Pharm Technol. 2011;27:15-8.

180. Candy B, Jones L, Vickerstaff V, et al. Mu-opioid antagonists for opioid-induced bowel dysfunction in people with cancer and people receiving palliative care. Cochrane Database Syst Rev. 2018 Jun 5;6:CD006332.Full text  Abstract

181. Ly KL, Chidgey J, Addington-Hall J, et al. Depression in palliative care: a systematic review. Part 2. Treatment. Palliat Med. 2002 Jul;16(4):279-84. Abstract

182. Education for Physicians on End-of-life Care (EPEC). Trainer's guide, module 6. Princeton, NJ: The Robert Wood Johnson Foundation; 1999.

183. Dileo C. Effects of music and music therapy on medical patients: a meta-analysis of the research and implications for the future. J Soc Integr Oncol. 2006 Spring;4(2):67-70. Abstract

184. Li M, Fitzgerald P, Rodin G. Evidence-based treatment of depression in patients with cancer. J Clin Oncol. 2012 Apr 10;30(11):1187-96. Abstract

185. Aalbers S, Fusar-Poli L, Freeman RE, et al. Music therapy for depression. Cochrane Database Syst Rev. 2017 Nov 16;11:CD004517.Full text  Abstract

186. Ream E, Richardson A, Expander-Dann C. Supportive intervention for fatigue in patients undergoing chemotherapy: a randomized controlled trial. J Pain Symptom Manage. 2006 Feb;31(2):148-61. Abstract

187. Andersen BL, DeRubeis RJ, Berman BS, et al. Screening, assessment, and care of anxiety and depressive symptoms in adults with cancer: an American Society of Clinical Oncology guideline adaptation. J Clin Oncol. 2014 May 20;32(15):1605-19.Full text  Abstract

188. Unutzer JN. Late-life depression. N Engl J Med. 2007 Nov 29;357(22):2269-76. Abstract

189. Ostuzzi G, Matcham F, Dauchy S, et al. Antidepressants for the treatment of depression in people with cancer. Cochrane Database Syst Rev. 2018 Apr 23;4:CD011006.Full text  Abstract

190. Rodin G, Lloyd N, Katz M, et al. The treatment of depression in cancer patients: a systematic review. Support Care Cancer. 2007 Feb;15(2):123-36. Abstract

191. Andersen BL, DeRubeis RJ, Berman BS, et al; American Society of Clinical Oncology. Screening, assessment, and care of anxiety and depressive symptoms in adults with cancer: an American Society of Clinical Oncology guideline adaptation. J Clin Oncol. 2014 May 20;32(15):1605-19.Full text  Abstract

192. Candy B, Jones L, Williams R, et al. Psychostimulants for depression. Cochrane Database Syst Rev. 2008 Apr 16;(2):CD006722.Full text  Abstract

193. Rayner L, Price A, Hotopf M, et al. The development of evidence-based European guidelines on the management of depression in palliative cancer care. Eur J Cancer. 2011 Mar;47(5):702-12. Abstract

194. Rayner L, Price A, Evans A, et al. Antidepressants for the treatment of depression in palliative care: systematic review and meta-analysis. Palliat Med. 2011 Jan;25(1):36-51. Abstract

195. Periyakoil VS, Skultety K, Sheikh J. Panic, anxiety, and chronic dyspnea. J Palliat Med. 2005 Apr;8(2):453-9. Abstract

196. Thekkumpurath P, Venkateswaran C, Kumar M, et al. Screening for psychological distress in palliative care: a systematic review. J Pain Symptom Manage. 2008 Nov;36(5):520-8. Abstract

197. Traeger L, Greer JA, Fernandez-Robles C, et al. Evidence-based treatment of anxiety in patients with cancer. J Clin Oncol2012 Apr 10;30(11):1197-205. Abstract

198. Nübling G, Allmendinger S, Lorenzl S. Drug therapy of anxiety and fear in palliative care patients with cancer or other illnesses: a systematic review [in German]. Schmerz. 2014 Sep 19;7:345-58. Abstract

199. Salt S, Mulvaney CA, Preston NJ. Drug therapy for symptoms associated with anxiety in adult palliative care patients. Cochrane Database Syst Rev. 2017 May 18;5:CD004596.Full text  Abstract

200. Sood A, Barton DL, Bauer BA, et al. A critical review of complementary therapies for cancer-related fatigue. Integr Cancer Ther. 2007 Mar;6(1):8-13. Abstract

201. Strasser F, Luftner D, Possinger K, et al. Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, Phase III, randomized, double-blind, placebo-controlled clinical trial from the Cannabis-In-Cachexia-Study-Group. J Clin Oncol. 2006 Jul 20;24(21):3394-400. Abstract

202. Cramp F, Byron-Daniel J. Exercise for the management of cancer-related fatigue in adults. Cochrane Database Syst Rev. 2012 Nov 14;11:CD006145. Abstract

203. Lowe SS, Watanabe SM, Courneya KS. Physical activity as a supportive care intervention in palliative cancer patients: a systematic review. J Support Oncol. 2009 Jan-Feb;7(1):27-34. Abstract

204. Goedendorp MM, Knoop H, Gielissen MF, et al. The effects of cognitive behavioral therapy for postcancer fatigue on perceived cognitive disabilities and neuropsychological test performance. J Pain Symptom Manage. 2014 Jan;47(1):35-44. Abstract

205. Mustian KM, Alfano CM, Heckler C, et al. Comparison of pharmaceutical, psychological, and exercise treatments for cancer-related fatigue: a meta-analysis. JAMA Oncol. 2017 Jul 1;3(7):961-8. Abstract

206. Minton O, Richardson A, Sharpe M, et al. Drug therapy for the management of cancer related fatigue. Cochrane Database Syst Rev. 2010 Jul 7;(7):CD006704. Abstract

207. Minton O, Richardson A, Sharpe M, et al. Psychostimulants for the management of cancer-related fatigue: a systematic review and meta-analysis. J Pain Symptom Manage. 2011 Apr;41(4):761-7. Abstract

208. Mücke M, Mochamat M, Cuhls H, et al. Pharmacological treatments for fatigue associated with palliative care. Cochrane Database Syst Rev. 2015 May 30;2015(5):CD006788.Full text  Abstract

209. Moraska AR, Sood A, Dakhil SR, et al. Phase III, randomized, double-blind, placebo-controlled study of long-acting methylphenidate for cancer-related fatigue: North Central Cancer Treatment Group NCCTG-N05C7 Trial. J Clin Oncol. 2010 Aug 10;28(23):3673-9. Abstract

210. Yennurajalingam S, Frisbee-Hume S, Palmer JL, et al. Reduction of cancer-related fatigue with dexamethasone: a double-blind, randomized, placebo-controlled trial in patients with advanced cancer. J Clin Oncol. 2013 Sep 1;31(25):3076-82. Abstract

211. Ruiz Garcia V, López-Briz E, Carbonell Sanchis R, et al. Megestrol acetate for treatment of anorexia-cachexia syndrome. Cochrane Database Syst Rev. 2013 Mar 28;2013(3):CD004310.Full text  Abstract

212. Bodenner D, Spencer T, Riggs AT, et al. A retrospective study of the association between megestrol acetate administration and mortality among nursing home residents with clinically significant weight loss. Am J Geriatr Pharmacother. 2007 Jun;5(2):137-46. Abstract

213. Miller S, McNutt L, McCann MA, et al. Use of corticosteroids for anorexia in palliative medicine: a systematic review. J Palliat Med. 2014 Apr;17(4):482-5. Abstract

214. Dewey A, Baughan C, Dean T, et al. Eicosapentaenoic acid (EPA, an omega-3 fatty acid from fish oils) for the treatment of cancer cachexia. Cochrane Database Syst Rev. 2007 Jan 24;2007(1):CD004597. Abstract

215. Koretz RL, Avenell A, Lipman TO, et al. Does enteral nutrition affect clinical outcome? A systematic review of the randomized trials. Am J Gastroenterol. 2007 Feb;102(2):412-29. Abstract

216. Dy SM. Enteral and parenteral nutrition in terminally ill cancer patients: a review of the literature. Am J Hosp Palliat Care. 2006 Oct-Nov;23(5):369-77. Abstract

217. Good P, Richard R, Syrmis W, et al. Medically assisted nutrition for adult palliative care patients. Cochrane Database Syst Rev. 2014 Apr 23;(4):CD006274.Full text  Abstract

218. Bruera E, Hui D, Dalal S, et al. Parenteral hydration in patients with advanced cancer: a multicenter, double-blind, placebo-controlled randomized trial. J Clin Oncol. 2013 Jan 1;31(1):111-8.Full text  Abstract

219. Murphy LM, Lipman TO. Percutaneous endoscopic gastrostomy does not prolong survival in patients with dementia. Arch Intern Med. 2003 Jun 9;163(11):1351-3.Full text  Abstract

220. Sampson EL, Candy B, Jones L. Enteral tube feeding for older people with advanced dementia. Cochrane Database Syst Rev. 2009 Apr 15;2009(2):CD007209. Abstract

221. Sanders DS, Carter MJ, D'Silva J, et al. Survival analysis in percutaneous endoscopic gastrostomy feeding: a worse outcome in patients with dementia. Am J Gastroenterol. 2000 Jun;95(6):1472-5. Abstract

222. Teno JM, Gonzalo P, Mitchell SL, et al. Feeding tubes and the prevention or healing of pressure ulcers. Arch Intern Med. 2012 May 14;172(9):697-701. Abstract

223. American Geriatrics Society Ethics Committee and Clinical Practice and Models of Care Committee. American Geriatrics Society feeding tubes in advanced dementia position statement. J Am Geriatr Soc. 2014 Aug;62(8):1590-3.Full text  Abstract

224. Casarett DJ, Inouye SK. Diagnosis and management of delirium near the end of life. Ann Intern Med. 2001 Jul 3;135(1):32-40. Abstract

225. Young J, Inouye SK. Delirium in older people. BMJ. 2007 Apr 21;334(7598):842-6. Abstract

226. Breitbart W, Alici Y. Evidence-based treatment of delirium in patients with cancer. J Clin Oncol. 2012 Apr 10;30(11):1206-14. Abstract

227. Crawford GB, Agar MM, Quinn SJ, et al. Pharmacovigilance in hospice/palliative care: net effect of haloperidol for delirium. J Palliat Med. 2013 Nov;16(11):1335-41. Abstract

228. Candy B, Jackson KC, Jones L, et al. Drug therapy for delirium in terminally ill adult patients. Cochrane Database Syst Rev. 2012 Nov 14;11:CD004770. Abstract

229. Bush SH, Kanji S, Pereira JL, et al. Treating an established episode of delirium in palliative care: expert opinion and review of the current evidence base with recommendations for future development. J Pain Symptom Manage. 2014 Aug;48(2):231-48.Full text  Abstract

230. Lonergan E, Britton AM, Luxenberg J, et al. Antipsychotics for delirium. Cochrane Database Syst Rev. 2007 Apr 18;(2):CD005594. Abstract

231. Agar MR, Lawlor PG, Quinn S, et al. Efficacy of oral risperidone, haloperidol, or placebo for symptoms of delirium among patients in palliative care: a randomized clinical trial. JAMA Intern Med. 2017 Jan 1;177(1):34-42. Abstract

232. Schneider LS, Dagerman KS, Insel P. Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. JAMA. 2005 Oct 19;294(15):1934-43. Abstract

233. Wang PS, Schneeweiss S, Avorn J, et al. Risk of death in elderly users of conventional vs. atypical antipsychotic medications. N Engl J Med. 2005 Dec 1;353(22):2335-41.Full text  Abstract

234. Lonergan E, Luxenberg J, Sastre AA. Benzodiazepines for delirium. Cochrane Database Syst Rev. 2009 Oct 7;2009(4):CD006379. Abstract

235. Elie D, Gagnon P, Gagnon B, et al. Using psychostimulants in end-of-life patients with hypoactive delirium and cognitive disorders: a literature review [in French]. Can J Psych. 2010 Jun;55(6):386-93. Abstract

236. Ücok A, Gaebel W. Side effects of atypical antipsychotics: a brief overview. World Psychiatry. 2008 Feb;7(1):58-62.Full text  Abstract

237. Scorza K, Williams A, Phillips D, et al. Evaluation of nausea and vomiting. Am Fam Physician. 2007 Jul 1;76(1):76-84.Full text  Abstract

238. Hesketh PJ. Chemotherapy-induced nausea and vomiting. N Engl J Med. 2008 Jun 5;358(23):2482-94. Abstract

239. Mizukami N, Yamauchi M, Koike K, et al. Olanzapine for the prevention of chemotherapy-induced nausea and vomiting in patients receiving highly or moderately emetogenic chemotherapy: a randomized, double-blind, placebo-controlled study. J Pain Symptom Manage. 2014 Mar;47(3):542-50. Abstract

240. Navari RM, Qin R, Ruddy KJ, et al. Olanzapine for the prevention of chemotherapy-induced nausea and vomiting. N Engl J Med. 2016 Jul 14;375(2):134-42.Full text  Abstract

241. Sutherland A, Naessens K, Plugge E, et al. Olanzapine for the prevention and treatment of cancer-related nausea and vomiting in adults. Cochrane Database Syst Rev. 2018 Sep 21;9:CD012555.Full text  Abstract

242. Benze G, Alt-Epping B, Geyer A, et al. Treatment of nausea and vomiting with prokinetics and neuroleptics in palliative care patients: a review [in German]. Schmerz. 2012 Sep;26(5):500-14. Abstract

243. To TH, Agar M, Yates P, et al. Prescribing for nausea in palliative care: a cross-sectional national survey of Australian palliative medicine doctors. J Palliat Med. 2014 Sep;17(9):1032-6. Abstract

244. Smith LA, Azariah F, Lavender VT, et al. Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy. Cochrane Database Syst Rev. 2015 Nov 12;2015(11):CD009464.Full text  Abstract

245. Vayne-Bossert P, Haywood A, Good P, et al. Corticosteroids for adult patients with advanced cancer who have nausea and vomiting (not related to chemotherapy, radiotherapy, or surgery). Cochrane Database Syst Rev. 2017 Jul 3;7:CD012002.Full text  Abstract

246. Murray-Brown F, Dorman S. Haloperidol for the treatment of nausea and vomiting in palliative care patients. Cochrane Database Syst Rev. 2015 Nov 2;2015(11):CD006271.Full text  Abstract

247. Smith TJ, Ritter JK, Poklis JL, et al. ABH gel is not absorbed from the skin of normal volunteers. J Pain Symptom Manage. 2012 May;43(5):961-6.Full text  Abstract

248. Weschules DJ. Tolerability of the compound ABHR in hospice patients. J Palliat Med. 2005 Dec;8(6):1135-43. Abstract

249. Tulsky JA. Beyond advanced directives: importance of communication skills at the end of life. JAMA. 2005 Jul 20;294(3):359-65. Abstract

250. Education for Physicians on End-of-life Care (EPEC) Trainer's guide, plenary 2. Princeton, NJ: The Robert Wood Johnson Foundation; 1999.

251. Lo B, Steinbrook R. Resuscitating advance directives. Arch Intern Med. 2004 Jul 26;164(14):1501-6. Abstract

252. Chittenden EH, Clark ST, Pantilat SZ. Discussing resuscitation preferences with patients: challenges and rewards. J Hosp Med. 2006 Jul;1(4):231-40. Abstract

253. Dow LA, Matsuyama RK, Ramakrishnan V, et al. Paradoxes in advance care planning: the complex relationship of oncology patients, their physicians, and advance medical directives. J Clin Oncol. 2010 Jan 10;28(2):299-304. Abstract

254. Silveira MJ, Kim SY, Langa KM. Advance directives and outcomes of surrogate decision making before death. N Engl J Med. 2010 Apr 1;362(13):1211-8. Abstract

255. Detering KM, Hancock AD, Reade MC, et al. The impact of advance care planning on end of life care in elderly patients: randomised controlled trial. BMJ. 2010 Jan 10;28(2):299-304.Full text  Abstract

256. Abel J, Pring A, Rich A, et al. The impact of advance care planning of place of death, a hospice retrospective cohort study. BMJ Support Palliat Care. 2013 Jun;3(2):168-73.Full text  Abstract

257. Song MK, Ward SE, Fine JP, et al. Advance care planning and end-of-life decision making in dialysis: a randomized controlled trial targeting patients and their surrogates. Am J Kidney Dis. 2015 Nov;66(5):813-22. Abstract

258. POLST. Physician orders for life-sustaining treatment paradigm. 2012-2015 [internet publication].Full text

259. Tolle SW, Tilden VP, Nelson CA, et al. A prospective study of the efficacy of the physician order form for life-sustaining treatment. J Am Geriatr Soc. 1998 Sep;46(9):1097-102. Abstract

260. Meyers JL, Moore C, McGrory A, et al. Physician Orders for Life-Sustaining Treatment form: honoring end-of-life directives for nursing home residents. J Gerontol Nurs. 2004 Sep;30(9):37-46. Abstract

261. Lee MA, Brummel-Smith K, Meyer J, et al. Physician Orders for Life-Sustaining Treatment (POLST): outcomes in a PACE program. J Am Geriatr Soc. 2000 Oct;48(10):1219-25. Abstract

262. Hickman SE, Tolle SW, Brummel-Smith K, et al. Use of the Physician Orders for Life-Sustaining Treatment program in Oregon nursing facilities: beyond resuscitation status. J Am Geriatr Soc. 2004 Sep;52(9):1424-9. Abstract

263. Hickman SE, Nelson CA, Perrin NA, et al. A comparison of methods to communicate treatment preferences in nursing facilities: traditional practices versus the Physician Orders for Life-Sustaining Treatment program. J Am Geriatr Soc. 2010 Jul;58(7):1241-8.Full text  Abstract

264. Butler M, Ratner E, McCreedy E, et al. Decision aids for advance care planning: an overview of the state of the science. Ann Intern Med. 2014 Sep 16;161(6):408-18.Full text  Abstract

265. Sudore RL, Knight SJ, McMahan RD, et al. A novel website to prepare diverse older adults for decision making and advance care planning: a pilot study. J Pain Symptom Manage. 2014 Apr;47(4):674-86. Abstract

266. Van Scoy LJ, Reading JM, Scott AM, et al. Exploring the topics discussed during a conversation card game about death and dying: a content analysis. J Pain Symptom Manage. 2016 Nov;52(5):655-62. Abstract

267. Delgado-Guay MO, Rodriguez-Nunez A, De la Cruz V, et al. Advanced cancer patients' reported wishes at the end of life: a randomized controlled trial. Support Care Cancer. 2016 Oct;24(10):4273-81. Abstract

268. Carr MF, Mohr GJ. Palliative sedation as part of a continuum of palliative care. J Palliat Med. 2008 Jan-Feb;11(1):76-81. Abstract

269. De Graeff A, Dean M. Palliative sedation therapy in the last weeks of life: a literature review and recommendations for standards. J Palliat Med. 2007 Feb;10(1):67-85. Abstract

270. Kirk TW, Mahon MM. National Hospice and Palliative Care Organization (NHPCO) position statement and commentary on the use of palliative sedation in imminently dying terminally ill patients. J Pain Symptom Manage. 2010 May;39(5):914-23. Abstract

271. National Ethics Committee of the Veterans Health Administration. The ethics of palliative sedation as therapy of last resort. Am J Hosp Palliat Care. 2006 Dec-2007 Jan;23(6):483-91. Abstract

272. Bruce SD, Hendrix CC, Gentry JH. Palliative sedation in end-of-life care. J Hospice Palliat Nurs. 2006 Nov 1;8(6):320-7.

273. Schildmann EK, Schildmann J, Kiesewetter I. Medication and monitoring in palliative sedation therapy: a systematic review and quality assessment of published guidelines. J Pain Symptom Manage. 2015 Apr;49(4):734-46. Abstract

274. Maltoni M, Scarpi E, Rosati M, et al. Palliative sedation in end-of-life care and survival: a systematic review. J Clin Oncol. 2012 Apr 20;30(12):1378-83. Abstract

275. Claessens P, Menten J, Schotsmans P, et al. Palliative sedation: a review of the research literature. J Pain Symptom Manage. 2008 Sep;36(3):310-33. Abstract

276. Mercadante S, Intravaia G, Villari P, et al. Controlled sedation for refractory symptoms in dying patients. J Pain Symptom Manage. 2009 May;37(5):771-9. Abstract

277. Education for Physicians on End-of-life Care (EPEC). Trainer's guide, module 5. Princeton, NJ: The Robert Wood Johnson Foundation; 1999.

278. Oregon Health Authority: Public Health. Oregon Death with Dignity Act [internet publication].Full text

279. De Lima L, Woodruff R, Pettus K, et al. International Association for Hospice and Palliative Care position statement: euthanasia and physician-assisted suicide. J Palliat Med. 2017 Jan;20(1):8-14.Full text  Abstract

280. Agnew A, Manktelow R, Taylor B, et al. Bereavement needs assessment in specialist palliative care: a review of the literature. Palliat Med. 2010 Jan;24(1):46-59. Abstract

281. Chan RJ, Webster J, Bowers A. End-of-life care pathways for improving outcomes in caring for the dying. Cochrane Database Syst Rev. 2016 Feb 12;2(2):CD008006.Full text  Abstract

282. Clinical Practice Guidelines and Protocols in British Columbia. Palliative care for the patient with incurable cancer or advanced disease - part 1: approach to care. February 2017 [internet publication].Full text

283. Davidson KM. Evidence-based protocol: family bereavement support before and after the death of a nursing home resident. J Gerontol Nurs. 2003 Jan;29(1):10-8 Abstract

284. Department of Health (UK). End of life care strategy: promoting high quality care for all adults at the end of life. July 2008 [internet publication].Full text

285. Giannini A, Messeri A, Aprile A, et al. End-of-life decisions in pediatric intensive care: recommendations of the Italian Society of Neonatal and Pediatric Anesthesia and Intensive Care (SARNePI). Paediatr Anaesth. 2008 Nov;18(11):1089-95. Abstract

286. Gomm S, Farrington K; NHS Kidney Care, National End of Life Care Programme. End of life care in advanced kidney disease: a framework for implementation. June 2009 [internet publication].Full text

287. Green E, Zwaal C, Beals C, et al; Cancer Care Ontario. Cancer-related pain management: a report of evidence-based recommendations to guide practice. Clin J Pain. 2010 Jul-Aug;26(6):449-62. Abstract

288. Scottish Intercollegiate Guidelines Network. Control of pain in adults with cancer: a national clinical guideline. November 2008 [internet publication].Full text

289. National Consensus Project for Quality Palliative Care. Clinical Practice Guidelines for Quality Palliative Care, 4th edition. National Coalition for Hospice and Palliative Care; 2018.Full text

290. National Quality Forum. A national framework and preferred practices for palliative and hospice care quality. December 2006 [internet publication].Full text

291. Clayton JM, Hancock K, Parker S, et al. Sustaining hope when communicating with terminally ill patients and their families: a systematic review. Psychooncology. 2008 Jul;17(7):641-59. Abstract

292. Fischberg D, Bull J, Casarett D, et al; AAHPM Choosing Wisely Task Force. Five things physicians and patients should question in hospice and palliative medicine. J Pain Symptom Manage. 2013 Mar;45(3):595-605.Full text  Abstract

293. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: palliative care [internet publication].Full text

294. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: antiemesis [internet publication].Full text

295. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: cancer-related fatigue [internet publication].Full text

296. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: distress management [internet publication].Full text

297. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: survivorship [internet publication].Full text

298. Ferrell BR, Temel JS, Temin S, et al. Integration of palliative care into standard oncology care: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol. 2017 Jan;35(1):96-112.Full text  Abstract

299. Sokol-Hessner L, Zambeaux A, Little K, et al. “Conversation Ready”: A Framework for Improving End-of-Life Care (Second Edition). IHI White Paper. Boston, Massachusetts: Institute for Healthcare Improvement; 2019 [internet publication].Full text

300. Lanken PN, Terry PB, DeLisser HM, et al. An official American Thoracic Society clinical policy statement: palliative care for patients with respiratory diseases and critical illnesses. Am J Respir Crit Care Med. 2008 Apr 15;177(8):912-27.Full text  Abstract

301. Truog RD, Campbell ML, Curtis JR, et al. Recommendations for end-of-life care in the intensive care unit: a consensus statement by the American College of Critical Care Medicine. Crit Care Med. 2008 Mar;36(3):953-63. Abstract

302. National Association of Neonatal Nurses. Palliative and end-of-life care for newborns and infants: position statement #3063. February 2015 [internet publication].Full text

303. Bosslet GT, Pope TM, Rubenfeld GD, et al; American Thoracic Society/ American Association for Critical Care Nurses/ American College of Chest Physicians/ European Society for Intensive Care Medicine/ Society of Critical Care Medicine. An official ATS/AACN/ACCP/ESICM/SCCM policy statement: responding to requests for potentially inappropriate treatments in intensive care units. Am J Respir Crit Care Med. 2015 Jun 1;191(11):1318-30. Abstract

304. European Society for Medical Oncology (ESMO). Clinical Practice Guidelines on palliative care: advanced care planning. 2014 [internet publication].Full text

305. Jordan K, Aapro M, Kaasa S, et al. European Society for Medical Oncology (ESMO) position paper on supportive and palliative care. Ann Oncol. 2018 Jan 1;29(1):36-43. Abstract

306. Crawford GB, Dzierżanowski T, Hauser K, et al. Care of the adult cancer patient at the end of life: ESMO Clinical Practice Guidelines. ESMO Open. 2021 Aug;6(4):100225.Full text  Abstract

307. Hui D, Maddocks M, Johnson MJ, et al. Management of breathlessness in patients with cancer: ESMO Clinical Practice Guidelines†. ESMO Open. 2020 Dec;5(6):e001038.Full text  Abstract

308. National Institute for Health and Care Excellence. Care of dying adults in the last days of life. March 2017 [internet publication].Full text

309. National Institute for Health and Care Excellence. End-of-life care for infants, children and young people with life-limiting conditions: planning and management. December 2016 [internet publication].Full text

310. National Institute for Health and Care Excellence. Palliative care for adults: strong opioids for pain relief. May 2012 [internet publication].Full text

311. Scottish Palliative Care Guidelines. End of life care. December 2014 [internet publication].Full text

312. Osman H, Shrestha S, Temin S, et al. Palliative Care in the Global Setting: ASCO Resource-Stratified Practice Guideline. J Glob Oncol. 2018 Jul;4:1-24.Full text  Abstract

313. Surbone A, Baider L, Weitzman TS, et al. Psychosocial care for patients and their families is integral to supportive care in cancer: MASCC position statement. Support Care Cancer. 2015 Jun 1;191(11):1318-30. Abstract

314. Ford DW, Koch KA, Ray DE, et al. Palliative and end-of-life care in lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013 May;143(5 Suppl):e498S-e512S.Full text  Abstract

315. Australian Cancer Network Melanoma Guidelines Revision Working Party. Clinical practice guidelines for the management of melanoma in Australia and New Zealand. October 2008 [internet publication].Full text

316. Davidson PM, Macdonald PS, Newton PJ, et al. End stage heart failure patients: palliative care in general practice. Aust Fam Physician. 2010 Dec;39(12):916-20.Full text  Abstract

317. Holloway RG, Arnold RM, Creutzfeldt CJ, et al. Palliative and end-of-life care in stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014 Jun;45(6):1887-916.Full text  Abstract

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