Mesothelioma
小结
定义
病史和体格检查
关键诊断因素
- family history
- history of asbestos exposure
- age between 60 and 85 years
- shortness of breath
- diminished breath sounds
- dullness to percussion
其他诊断因素
- male sex
- chest pain
- cough
- constitutional symptoms
- abdominal distention and/or pain
危险因素
- asbestos exposure
- age 60 to 85 years
- asbestos exposure during home maintenance and renovation
- male sex
- radiation exposure
- genetic predisposition
- simian virus 40 (SV-40)
诊断性检查
首要检查
- CXR
- CT chest and upper abdomen (with contrast)
需考虑的检查
- thoracentesis
- PET/CT scan
- pleural biopsy
- video-assisted thoracoscopic surgery (VATS)
- immunohistochemistry
- germline testing
- chest MRI
- cervical mediastinoscopy
- pulmonary function tests
- CBC
- basic metabolic panel
新兴检查
- diagnostic biomarkers
治疗流程
resectable disease
unresectable or recurrent disease
撰稿人
作者
Hedy Kindler, MD
Professor of Medicine
Associate Dean for Clinical Science Research, Human Subjects
The University of Chicago, Biological Sciences Division
Section of Hematology/Oncology
Chicago
利益声明
HK declares she has no competing interests.
鸣谢
Dr Hedy Kindler would like to gratefully acknowledge Dr Idrees Mian, Dr Jaydira del Rivero, Dr Anish Thomas, Mrs Mary Hesdorffer, Dr Robert Taub, and Dr Chris R. Kelsey, the previous contributors to this topic.
利益声明
IM, JdR, AT, MH, RT, and CRK declare that they have no competing interests.
同行评议者
Marc de Perrot, MD, MSc
Associate Professor of Surgery
University of Toronto
Division of Thoracic Surgery
Toronto General Hospital
Ontario
Canada
利益声明
MdP is an author of a reference cited in this topic.
Tom Treasure, MD, MS FRCS, FRCP
Professor of Cardiothoracic Surgery (Honorary)
Clinical Operational Research Unit
Department of Mathematics
University College London
London
UK
利益声明
TT is an author of a reference cited in this topic.
Peer reviewer acknowledgements
BMJ Best Practice topics are updated on a rolling basis in line with developments in evidence and guidance. The peer reviewers listed here have reviewed the content at least once during the history of the topic.
Disclosures
Peer reviewer affiliations and disclosures pertain to the time of the review.
参考文献
关键文献
National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: mesothelioma: pleural [internet publication].全文
Woolhouse I, Bishop L, Darlison L, et al. British Thoracic Society guideline for the investigation and management of malignant pleural mesothelioma. Thorax. 2018 Mar;73(suppl 1):i1-30.全文 摘要
Popat S, Baas P, Faivre-Finn C, et al. Malignant pleural mesothelioma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2022 Feb;33(2):129-42.全文 摘要
Kindler HL, Ismaila N, Bazhenova L, et al. Treatment of pleural mesothelioma: ASCO guideline update. J Clin Oncol. 2025 Mar 10;43(8):1006-38.全文 摘要
参考文献
A full list of sources referenced in this topic is available to users with access to all of BMJ Best Practice.
დიფერენციული დიაგნოზები
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