Thymic tumor

References

Key articles

Girard N, Ruffini E, Marx A, et al. Thymic epithelial tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2015;26(suppl 5):v40-v55.Full text  Abstract

Detterbeck FC. Clinical value of the WHO classification system of thymoma. Ann Thorac Surg. 2006;81:2328-2334.Full text  Abstract

National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: thymomas and thymic carcinomas [internet publication].Full text

Korst RJ, Kansler AL, Christos PJ, et al. Adjuvant radiotherapy for thymic epithelial tumors: a systematic review and meta-analysis. Ann Thorac Surg. 2009;87:1641-1647. Abstract

Wright CD, Wain JC, Wong DR, et al. Predictors of recurrence in thymic tumors: importance of invasion, World Health Organization histology and size. J Thorac Cardiovasc Surg. 2005;130:1413-1421. Abstract

Schmitt J, Loehrer PJ. The role of chemotherapy in advanced thymoma. J Thorac Oncol. 2010;5(suppl 4):357S-360S. Abstract

Lucchi M, Mussi A. Surgical treatment of recurrent thymomas. J Thorac Oncol. 2010;5(suppl 4):348S-351S. Abstract

Reference articles

1. Engels EA, Pfeiffer RM. Malignant thymoma in the United States: demographic patterns in incidence and associations with subsequent malignancies. Int J Cancer. 2003 Jul 1;105(4):546-51.Full text  Abstract

2. Girard N, Ruffini E, Marx A, et al. Thymic epithelial tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2015;26(suppl 5):v40-v55.Full text  Abstract

3. Detterbeck FC. Clinical value of the WHO classification system of thymoma. Ann Thorac Surg. 2006;81:2328-2334.Full text  Abstract

4. Shimosato Y, Mukai K. Tumors of the mediastinum. In: Rosai J, Sobin LH, eds. Atlas of tumor pathology. Washington, DC: Armed Forces Institute of Pathology; 1997:93-115.

5. Travis W, Brambilla E, Burke A, et al. Tumours of the thymus. In: WHO classification of tumours of the lung, pleura, thymus and heart. 4th ed. Lyon, France: IARC Press; 2015:184-298.

6. Detterbeck F, Parsons A. Thymic tumors: a review of current diagnosis, classification, and treatment. In: Patterson GA, Cooper JD, Deslauriers J, et al, eds. Thoracic and esophageal surgery, 3rd edition. Philadelphia, PA: Elsevier; 2008:1589-614.

7. Detterbeck FC, Parsons AM. Thymic tumors. Ann Thorac Surg. 2004 May;77(5):1860-9.Full text  Abstract

8. Suadjian J, Enriquez P, Silverstein MN, et al. The spectrum of diseases associated with thymoma: coincidence or syndrome? Arch Intern Med. 1974;154:374-379. Abstract

9. Cugell DW, Kamp DW. Asbestos and the pleura: a review. Chest. 2004;125:1103-1117. Abstract

10. Okumura M, Ohta M, Tateyama H, et al. The World Health Organization histologic classification system reflects the oncologic behavior of thymoma: a clinical study of 273 patients. Cancer. 2002 Feb 1;94(3):624-32.Full text  Abstract

11. Kondo K, Monden Y. Therapy for thymic epithelial tumors: a clinical study of 1,320 patients from Japan. Ann Thorac Surg. 2003;75:878-885. Abstract

12. Filosso PL, Actis Dato GM, Ruffini E, et al. Multidisciplinary treatment of advanced thymic neuroendocrine carcinoma (carcinoid): report of a successful case and review of the literature. J Thorac Cardiovasc Surg. 2004;127:1215-1219. Abstract

13. Wightman SC, Shrager JB. Non-myasthenia gravis immune syndromes and the thymus: is there a role for thymectomy? Thorac Surg Clin. 2019 May;29(2):215-25. Abstract

14. Phan AT, Öberg K, Choi J, et al. NANETS consensus guideline for the diagnosis and management of neuroendocrine tumors: well-differentiated neuroendocrine tumors of the thorax (includes lung and thymus). Pancreas. 2010;39:784-798.Full text  Abstract

15. Kattach H, Hasan S, Clelland C, et al. Seeding of stage I thymoma into the chest wall 12 years after needle biopsy. Ann Thorac Surg. 2005 Jan;79(1):323-4.Full text  Abstract

16. Nagasaka T, Nakashima N, Nunome H. Needle tract implantation of thymoma after transthoracic needle biopsy. J Clin Pathol. 1993 Mar;46(3):278-9.Full text  Abstract

17. Byrd CT, Trope WL, Bhandari P, et al. Positron emission tomography/computed tomography differentiates resectable thymoma from anterior mediastinal lymphoma. J Thorac Cardiovasc Surg. 2022 Apr 1:S0022-5223(22)00367-1. Abstract

18. Drachman DB. Myasthenia gravis. N Engl J Med. 1994;330:1797-1810. Abstract

19. Wudel LJ Jr, Nesbitt JC. Superior vena cava syndrome. Curr Treat Options Oncol. 2001 Feb;2(1):77-91. Abstract

20. Marom EM. Imaging thymoma. J Thorac Oncol. 2010;5(suppl 4):296S-303S. Abstract

21. Inaoka T, Takahashi K, Mineta M, et al. Thymic hyperplasia and thymus gland tumors: differentiation with chemical shift MR imaging. Radiology. 2007;243:869-876. Abstract

22. Kitami A, Sano F, Ohashi S, et al. The usefulness of positron-emission tomography findings in the management of anterior mediastinal tumors. Ann Thorac Cardiovasc Surg. 2017 Feb 20;23(1):26-30.Full text  Abstract

23. Luzzi L, Campione A, Gorla A, et al. Role of fluorine-flurodeoxyglucose positron emission tomography/computed tomography in preoperative assessment of anterior mediastinal masses. Eur J Cardiothorac Surg. 2009 Sep;36(3):475-9.Full text  Abstract

24. Amin M, Edge B, Greene F, et al; American Joint Commission on Cancer. AJCC cancer staging manual. 8th ed. New York, NY: Springer International Publishing; 2017.

25. Howard FM Jr, Lennon VA, Finley J, et al. Clinical correlations of antibodies that bind, block, or modulate human acetylcholine receptors in myasthenia gravis. Ann N Y Acad Sci. 1987 Aug;505(1):526-38. Abstract

26. Zekeridou A, McKeon A, Lennon VA. Frequency of synaptic autoantibody accompaniments and neurological manifestations of thymoma. JAMA Neurol. 2016 Jul 1;73(7):853-9.Full text  Abstract

27. Maher MM, Shepard JA. Imaging of thymoma. Semin Thorac Cardiovasc Surg. 2005;17:12-19. Abstract

28. Masaoka A, Monden Y, Nakahara K, et al. Follow-up study of thymomas with special reference to their clinical stages. Cancer. 1981;48:2485-2492. Abstract

29. Masaoka A, Yamakawa Y, Niwa H, et al. Thymectomy and malignancy. Eur J Cardiothorac Surg. 1994;8:251-253. Abstract

30. Masaoka A. Staging system of thymoma. J Thorac Oncol. 2010;5(suppl 4):304S-312S. Abstract

31. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: thymomas and thymic carcinomas [internet publication].Full text

32. Baudin E, Caplin M, Garcia-Carbonero R, et al. Lung and thymic carcinoids: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2021 Apr;32(4):439-51.Full text  Abstract

33. Titulaer MJ, Soffietti R, Dalmau J, et al. Screening for tumours in paraneoplastic syndromes: report of an EFNS task force. Eur J Neurol. 2011;18:19-e3.Full text  Abstract

34. Cancer Care Ontario. Surgical, radiation, and systemic treatments of patients with thymic epithelial tumours. March 2022 [internet publication].Full text

35. Ettinger DS, Akerley W, Bepler G, et al; National Comprehensive Cancer Network. Thymic malignancies. J Natl Compr Canc Netw. 2010;8:1302-1315.Full text  Abstract

36. Davenport E, Malthaner RA. The role of surgery in the management of thymoma: a systematic review. Ann Thorac Surg. 2008;86:673-684. Abstract

37. Nakagawa K, Yokoi K, Nakajima J, et al. Is thymomectomy alone appropriate for stage I (T1N0M0) thymoma? Results of a propensity-score analysis. Ann Thorac Surg. 2016 Feb;101(2):520-6.Full text  Abstract

38. Voulaz E, Veronesi G, Infante M, et al. Radical thymectomy versus conservative thymomectomy in the surgical treatment of thymic malignancies. J Thorac Dis. 2018 Jul;10(7):4127-4136.Full text  Abstract

39. Tseng YC, Hsieh CC, Huang HY, et al. Is thymectomy necessary in nonmyasthenic patients with early thymoma? J Thorac Oncol. 2013 Jul;8(7):952-8.Full text  Abstract

40. Yang CJ, Hurd J, Shah SA, et al. A national analysis of open versus minimally invasive thymectomy for stage I to III thymoma. J Thorac Cardiovasc Surg. 2020 Aug;160(2):555-567.e15.Full text  Abstract

41. Friedant AJ, Handorf EA, Su S, et al. Minimally invasive versus open thymectomy for thymic malignancies: systematic review and meta-analysis. J Thorac Oncol. 2016 Jan;11(1):30-8.Full text  Abstract

42. Liu TJ, Lin MW, Hsieh MS, et al. Video-assisted thoracoscopic surgical thymectomy to treat early thymoma: a comparison with the conventional transsternal approach. Ann Surg Oncol. 2014 Jan;21(1):322-8. Abstract

43. Manoly I, Whistance RN, Sreekumar R, et al. Early and mid-term outcomes of trans-sternal and video-assisted thoracoscopic surgery for thymoma. Eur J Cardiothorac Surg. 2014 Jun;45(6):e187-93.Full text  Abstract

44. Sakamaki Y, Oda T, Kanazawa G, et al. Intermediate-term oncologic outcomes after video-assisted thoracoscopic thymectomy for early-stage thymoma. J Thorac Cardiovasc Surg. 2014 Oct;148(4):1230-7.e1.Full text  Abstract

45. Ye B, Tantai JC, Ge XX, et al. Surgical techniques for early-stage thymoma: video-assisted thoracoscopic thymectomy versus transsternal thymectomy. J Thorac Cardiovasc Surg. 2014 May;147(5):1599-603.Full text  Abstract

46. Pennathur A, Qureshi I, Schuchert MJ, et al. Comparison of surgical techniques for early-stage thymoma: feasibility of minimally invasive thymectomy and comparison with open resection. J Thorac Cardiovasc Surg. 2011 Mar;141(3):694-701.Full text  Abstract

47. Mangi AA, Wright CD, Allan JS, et al. Adjuvant radiation therapy for stage II thymoma. Ann Thorac Surg. 2002;74:1033-1037. Abstract

48. Korst RJ, Kansler AL, Christos PJ, et al. Adjuvant radiotherapy for thymic epithelial tumors: a systematic review and meta-analysis. Ann Thorac Surg. 2009;87:1641-1647. Abstract

49. Giannopoulou A, Gkiozos I, Harrington KJ, et al. Thymoma and radiation therapy: a systematic review of medical treatment. Expert Rev Anticancer Ther. 2013;13:759-766. Abstract

50. Venuta F, Rendina EA, Longo F, et al. Long-term outcome after multimodality treatment for stage III thymic tumors. Ann Thorac Surg. 2003;76:1866-1872. Abstract

51. Huang J, Rizk NP, Travis WD, et al. Feasibility of multimodality therapy including extended resections in stage IVA thymoma. J Thorac Cardiovasc Surg. 2007;134:1477-1484. Abstract

52. Loehrer PJ, Jiroutek M, Aisner S, et al. Combined etoposide, ifosfamide and cisplatin in the treatment of patients with advanced thymoma and thymic carcinoma: an intergroup trial. Cancer. 2001;91:2010-2015. Abstract

53. Riely GJ, Huang J. Induction therapy for locally advanced thymoma. J Thorac Oncol. 2010;5(suppl 4):323S-326S. Abstract

54. Wright CD, Choi NC, Wain JC, et al. Induction chemoradiotherapy followed by resection for locally advanced Masaoka stage III and IVA thymic tumors. Ann Thorac Surg. 2008;85:385-389. Abstract

55. Loehrer PJ Sr, Chen M, Kim K, et al. Cisplatin, doxorubicin, and cyclophosphamide plus thoracic radiation therapy for limited-stage unresectable thymoma: an intergroup trial. J Clin Oncol. 1997;15:3093-3099. Abstract

56. Wright CD, Wain JC, Wong DR, et al. Predictors of recurrence in thymic tumors: importance of invasion, World Health Organization histology and size. J Thorac Cardiovasc Surg. 2005;130:1413-1421. Abstract

57. Huang J, Rizk NP, Travis WD. Comparison of patterns of relapse in thymic carcinoma and thymoma. J Thorac Cardiovasc Surg. 2009;138:26-31. Abstract

58. Schmitt J, Loehrer PJ. The role of chemotherapy in advanced thymoma. J Thorac Oncol. 2010;5(suppl 4):357S-360S. Abstract

59. Wright CD. Pleuropneumonectomy for the treatment of Masaoka stage IVA thymoma. Ann Thorac Surg. 2006;82:1234-1239. Abstract

60. Eng TY, Thomas CR. Radiation therapy in the management of thymic tumors. Semin Thorac Cardiovasc Surg. 2005;17:32-40. Abstract

61. Lucchi M, Mussi A. Surgical treatment of recurrent thymomas. J Thorac Oncol. 2010;5(suppl 4):348S-351S. Abstract

62. Skeie GO, Apostolski S, Evoli A, et al. Guidelines for treatment of autoimmune neuromuscular transmission disorders. Eur J Neurol. 2010;17:893-902. Abstract

63. Yokoyama S, Miyoshi H. Thymic tumors and immune checkpoint inhibitors. J Thorac Dis. 2018 May;10(suppl 13):S1509-15.Full text  Abstract

64. Cho J, Kim HS, Ku BM, et al. Pembrolizumab for patients with refractory or relapsed thymic epithelial tumor: an open-label phase II trial. J Clin Oncol. 2019 Aug 20;37(24):2162-70. Abstract

65. Giaccone G, Kim C, Thompson J, et al. Pembrolizumab in patients with thymic carcinoma: a single-arm, single-centre, phase 2 study. Lancet Oncol. 2018 Mar;19(3):347-55. Abstract

66. Giaccone G, Kim C. Durable response in patients with thymic carcinoma treated with pembrolizumab after prolonged follow-up. J Thorac Oncol. 2021 Mar;16(3):483-5.Full text  Abstract

67. Rajan A, Heery CR, Thomas A, et al. Efficacy and tolerability of anti-programmed death-ligand 1 (PD-L1) antibody (Avelumab) treatment in advanced thymoma. J Immunother Cancer. 2019 Oct 21;7(1):269.Full text  Abstract

68. Kang SY, Lee JS, Choi JC, Kang JH. Myasthenia gravis appearing after thymectomy: a case report and review of the literature. J Clin Neurol. 2007;3:158-160.Full text  Abstract

69. Welsh JS, Wilkins KB, Green R, et al. Association between thymoma and second neoplasms. JAMA. 2000;283:1142-1143. Abstract

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