Summary
Definition
History and exam
Key diagnostic factors
- presence of risk factors
- fever
- myalgia
- malaise
- bleeding
- macular or petechial rash
Other diagnostic factors
- headache
- nausea
- abdominal pain
- hepatomegaly
- splenomegaly
- somnolence
- diarrhoea
- hypotension
- conjunctivitis
- arthralgia
Risk factors
- residency in or recent travel to CCHF-endemic region
- history of tick exposure
- contact with infected body fluids
- occupational exposure
- contact with infected animals
- unprotected sexual contact with an infected individual
Diagnostic investigations
1st investigations to order
- reverse transcription-polymerase chain reaction (RT-PCR)
- malaria investigations
Investigations to consider
- serology
- FBC
- coagulation studies
- LFTs
- serum creatinine and urea
- urinalysis
- serum electrolytes
- lactate dehydrogenase
- creatinine phosphokinase
Treatment algorithm
potential exposure
suspected or confirmed infection
Contributors
Authors
Onder Ergonul, MD, MPH
Professor
Infectious Diseases and Public Health
Koç University School of Medicine
Chair
lnfectious Diseases and Clinical Microbiology Department
American Hospital
President
Turkish Society of Clinical Microbiology and Infectious Diseases
Istanbul
Turkey
Disclosures
OE is the author of references cited in this topic.
Peer reviewers
Vanessa Raabe, MD, MSc
Adult and Pediatric Infectious Disease Fellow
Emory University
Atlanta
GA
Disclosures
VR declares that she has no competing interests.
Tom Fletcher, MBChB, MRCP, DTM&H
Wellcome Trust/MoD Research Fellow
Liverpool School of Tropical Medicine
Liverpool
UK
Disclosures
TF receives Crimean-Congo haemorrhagic fever research funding from the Wellcome Trust and UK Surgeon General. He is a member of the WHO secretariat for Crimean-Congo haemorrhagic fever guideline development.
Ayşe Erbay, MD, MPH
Professor of Infectious Diseases
Faculty of Medicine
Bozok University
Yozgat
Turkey
Disclosures
AE declares that she has no competing interests.
Differentials
- Malaria infection
- Ebola virus infection
- Lassa fever
More DifferentialsGuidelines
- Crimean-Congo haemorrhagic fever: origins, reservoirs, transmission and guidelines
- CDC health information for international travel (Yellow Book): viral hemorrhagic fevers
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