Last reviewed: November 2017
Last updated: May  2017

Summary

Definition

History and exam

Key diagnostic factors

  • hx of residence in, or recent travel to, endemic area
  • lack of yellow fever immunization
  • hx of mosquito bite
  • fever
  • constitutional symptoms
  • conjunctival injection
  • relative bradycardia (Faget sign)
  • biphasic illness
  • jaundice
  • hemorrhagic diathesis
  • signs of renal failure
  • signs of hepatic failure

Other diagnostic factors

  • hypotension
  • abdominal pain
  • vomiting
  • lethargy

Risk factors

  • residence in, or recent travel to, endemic area
  • lack of immunization
  • mosquito bite
  • travel during rainy and early dry seasons

Diagnostic investigations

1st investigations to order

  • CBC
  • LFTs
  • coagulation screen
  • reverse transcription polymerase chain reaction (RT-PCR)
  • serology
Full details

Emerging tests

  • virus isolation
  • isothermal nucleic acid amplification assays
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Helmut Albrecht

Heyward Gibbes Distinguished Professor of Internal Medicine

Chair

Department of Internal Medicine

University of South Carolina

Columbia

SC

Disclosures

HA declares that he has no competing interests.

Dr Albrecht would like to gratefully acknowledge Dr Philip A. Yeon, a previous contributor to this monograph. PAY declares that he has no competing interests.

Peer reviewers VIEW ALL

Assistant Professor

Emory University

TravelWell Clinic

Emory University Hospital Midtown

Atlanta

GA

Disclosures

CFP declares that he has no competing interests.

Clinical Assistant

Tropical Diseases Unit

Division of Infectious Diseases

Department of Medicine

Toronto General Hospital

University Health Network

Toronto

Canada

Disclosures

AKB declares that she has no competing interests.

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