Last reviewed: November 2017
Last updated: November  2017

Summary

Definition

History and exam

Key diagnostic factors

  • hx of travel to affected area
  • hx of close contact with infected individuals
  • hx of laboratory work on SARS coronavirus (CoV)
  • fever
  • cough
  • myalgia
  • dyspnea

Other diagnostic factors

  • chills or rigors
  • malaise
  • headache
  • watery diarrhea
  • tachypnea
  • tachycardia
  • cyanosis
  • nausea and vomiting
  • sore throat
  • sputum production
  • chest pain
  • pleurisy
  • rhinorrhea
  • dizziness
  • arthralgia
  • abdominal pain
  • seizure
  • delirium
  • rales
  • inspiratory crackles
  • bronchial breathing

Risk factors

  • travel to affected area
  • close contact with infected individuals
  • laboratory work on SARS coronavirus (CoV)

Diagnostic investigations

1st investigations to order

  • CBC
  • aminotransferases
  • lactate dehydrogenase
  • creatine kinase
  • blood culture
  • sputum culture
  • nasopharyngeal virus culture
  • direct immunofluorescent antibody staining
  • CXR
  • pulse oximetry
  • reverse-transcription polymerase chain reaction (RT-PCR)
Full details

Investigations to consider

  • ABG
  • coagulation screen
  • high-resolution CT (HRCT) of thorax
  • serologic testing for SARS coronavirus (CoV)-specific antibodies
  • viral culture
Full details

Emerging tests

  • rapid immunoswab assay for SARS coronavirus (CoV) detection
  • monoclonal antibodies
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Georgia G. Pitsiou

Assistant Professor in Pulmonary Medicine

Aristotle University of Thessaloniki

Respiratory Failure Unit

General Hospital G. Papanikolaou

Thessaloniki

Greece

Disclosures

GGP declares that she has no competing interests.

Ioannis P. Kioumis

Associate Professor in Pulmonary Medicine

Infectious Diseases

Aristotle University of Thessaloniki

Respiratory Medicine Clinic

General Hospital G. Papanikolaou

Thessaloniki

Greece

Disclosures

IPK declares that he has no competing interests.

Peer reviewers VIEW ALL

Attending Pathologist

Montefiore Medical Center

Bronx

NY

Disclosures

TRT declares that he has no competing interests.

Director of the School of Public Health

Chinese University of Hong Kong

Prince of Wales Hospital

New Territories

Hong Kong

Disclosures

SG declares that she has no competing interests.

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