Last reviewed: November 2017
Last updated: August  2017

Summary

Definition

History and exam

Other diagnostic factors

  • middle age
  • headache
  • weight loss
  • poor skin turgor
  • flushing
  • hx of type 1 multiple endocrine neoplasia

Risk factors

  • type 1 multiple endocrine neoplasia
  • middle age

Diagnostic investigations

1st investigations to order

  • serum potassium
  • serum bicarbonate
  • serum calcium
  • serum glucose
  • VIP radioimmunoassay
  • LFTs
Full details

Investigations to consider

  • arterial blood gas analysis
  • gastric PH monitoring
  • chromogranin A
  • pancreatic polypeptide
  • ultrasound
  • contrast-enhanced thin-slice CT scan of abdomen
  • contrast-enhanced MRI of abdomen
  • somatostatin receptor scintigraphy
  • endoscopic ultrasound
  • operative exploration
  • intraoperative ultrasound
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Harish Lavu

Associate Professor of Surgery

Jefferson Medical College

Thomas Jefferson University

Philadelphia

PA

Disclosures

HL declares that he has no competing interests.

Charles J. Yeo

The Samuel D. Gross Professor and Chair

Department of Surgery

Jefferson Medical College

Thomas Jefferson University

Philadelphia

PA

Disclosures

CJY declares that he has no competing interests.

Peer reviewers VIEW ALL

Fellow of the Spanish Association of Surgeons (AEC)

Department of Surgery

University Hospital Ramon y Cajal

Madrid

Spain

Disclosures

JRT declares that he has no competing interests.

Assistant Professor of Surgery and Oncology

Cameron Division of Surgical Oncology

The Sol Goldman Pancreatic Cancer Research Center

Johns Hopkins University

Baltimore

MD

Disclosures

CW declares that he has no competing interests.

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