An esophageal motor disorder characterized by a loss of esophageal peristalsis and failure of the lower esophageal sphincter to relax in response to swallowing.
The most common presenting symptoms are dysphagia to solids and liquids, regurgitation, and retrosternal pain. These can be slowly progressive over months or years.
The first investigation for any patient with dysphagia is endoscopy to exclude malignancy, but subsequent barium swallow studies and esophageal manometry are usually required to establish the diagnosis of achalasia.
Treatment is symptomatic, not curative, and is primarily aimed at relieving dysphagia; options include pharmacologic, endoscopic, and surgical procedures.
Achalasia, from the Greek for "does not relax", is an esophageal motor disorder of unknown etiology, characterized by esophageal aperistalsis and insufficient lower esophageal sphincter (LOS) relaxation in response to swallowing. This results from loss of inhibitory nitrinergic neurons in the esophageal myenteric plexus.
Honorary Consultant Gastroenterologist
St George's Hospital
JYK declares that he has no competing interests.
Dr Jin-Yong Kang would like to gratefully acknowledge Kalliopi Alexandropoulou, a previous contributor to this topic. KA declares that she has no competing interests.
Sandwell General Hospital
NT declares that he has no competing interests.
Consultant in General Medicine
Leicester General Hospital
JdC declares that he has no competing interests.
Assistant Professor of Surgery
Children's Hospital of Pittsburgh
DH declares that he has no competing interests.
Professor of Medicine
University of Connecticut Health Center
GYW is on the medical advisory boards of the following: Gilead Sciences, Bristol-Myers Squibb, AbbVie, and Intercept.
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