Last reviewed: November 2017
Last updated: July  2016

Summary

Definition

History and exam

Key diagnostic factors

  • hx of asthma
  • hx of cystic fibrosis (CF)
  • teenage and young adulthood
  • hx of atopy
  • cough
  • mucus plugs
  • wheezing

Other diagnostic factors

  • fever
  • pleuritic chest pain
  • finger clubbing
  • cyanosis
  • weight loss

Risk factors

  • asthma
  • cystic fibrosis (CF)
  • atopy
  • HLA-DR2- and HLA-DR5-positive
  • IL-10 promoter polymorphisms
  • surfactant protein polymorphisms
  • CFTR gene

Diagnostic investigations

1st investigations to order

  • skin test for Aspergillus fumigatus sensitivity
  • serum total IgE
  • CBC with peripheral blood eosinophil count
  • chest x-ray
Full details

Investigations to consider

  • serum-specific IgG
  • serum-specific IgE
  • sputum culture and microscopy
  • CT chest
  • HLA antigens
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Staff Physician

Department of Pulmonary, Allergy and Critical Care

Cleveland Clinic

Cleveland

OH

Disclosures

CR is on the Advisory Board for CSL Behring.

Peer reviewers VIEW ALL

Professor

Department of Pediatrics

University of Bern

Bern

Switzerland

Disclosures

MS declares that he has no competing interests.

Professor of Pediatrics

Allergy-Immunology Division

Medical College of Wisconsin

Milwaukee

WI

Disclosures

JF is an author of a number of references cited in this monograph.

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