Last reviewed: November 2017
Last updated: November  2017

Summary

Definition

History and exam

Key diagnostic factors

  • prior hx of maternal sensitization to RhD or hydrops, multiparity, maternal RhD-negative status, invasive fetal procedures, placental trauma, and abortion (threatened, spontaneous, or induced)

Risk factors

  • maternal RhD-negative status
  • maternal sensitization to RhD
  • invasive fetal procedures
  • placental trauma
  • abortion
  • multiparity
  • previous hydrops
  • external cephalic version
  • molar pregnancy
  • ectopic pregnancy

Diagnostic investigations

1st investigations to order

  • maternal blood type
  • maternal serum Rh antibody screen
Full details

Investigations to consider

  • maternal serum antibody titer
  • paternal blood type
  • paternal zygosity
  • fetal ultrasound
  • Doppler velocimetry of fetal middle cerebral artery-peak systolic velocity
  • fetal blood typing (from amniocentesis or maternal circulation)
  • direct assessment of fetal anemia
  • rosette test
  • Kleihauer-Betke test/flow cytometry
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Program Director

Maternal Fetal Medicine

Associate Professor

Department of OB/GYN

The Ottawa Hospital

University of Ottawa

Ottawa

Canada

Disclosures

KFKF is an author of a reference cited in this monograph. KFKF declares that she has no competing interests.

Assistant Professor

Maternal Fetal Medicine Division

The Ottawa Hospital

University of Ottawa

Ottawa

Canada

Disclosures

FM declares that he has no competing interests.

Peer reviewers VIEW ALL

Honorary Professor of Medicine

University of Glasgow

Glasgow

UK

Disclosures

AC is an author of several references cited in this monograph.

Consultant Hematologist

Bradford Teaching Hospitals NHS Trust

Yorkshire Clinic

Bingley

Bradford

UK

Disclosures

LAP declares that he has no competing interests.

Professor of Obstetrics and Gynecology

Texas Children's Fetal Center

Baylor College of Medicine/Texas Children's Hospital

Houston

TX

Disclosures

KJM declares that he has no competing interests.

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