Last reviewed: November 2017
Last updated: August  2016

Summary

Definition

History and exam

Key diagnostic factors

  • family history of FAP/attenuated FAP
  • teenager
  • onset of colorectal cancer in middle age
  • bilateral pigmentation of the retina

Other diagnostic factors

  • constipation/diarrhea
  • hematochezia
  • features of Gardner variant FAP

Risk factors

  • germline APC gene mutation
  • family history of FAP or attenuated FAP

Diagnostic investigations

1st investigations to order

  • colonoscopy
  • extended-side-viewing esophagogastroduodenoscopy
Full details

Investigations to consider

  • genetic testing for adenomatous polyposis coli (APC) gene mutations
  • abdominal imaging with CT or MRI
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Colorectal Surgeon

Colon and Rectal Surgery, Inc

Associate Clinical Professor of Surgery

Creighton University School of Medicine

Clinical Professor of Surgery

University of Nebraska College of Medicine

Omaha

NE

Disclosures

CAT declares that he has no competing interests.

Clinical Professor of Surgery

Colon and Rectal Surgery

Creighton University School of Medicine

University of Nebraska College of Medicine

Omaha

NE

Disclosures

AGT declares that he has no competing interests.

Dr Charles A. Ternent and Dr Alan G. Thorson would like to gratefully acknowledge Dr Lisa A. Boardman and Dr Douglas L. Riegert-Johnson, the previous contributors to this monograph. LAB and DLRJ declare that they have no competing interests.

Peer reviewers VIEW ALL

Professor of General Surgery

Department of Digestive Surgery

Hopital Saint-Antoine

Universite Pierre et Marie Curie Paris VI

Paris

France

Disclosures

YP declares that he has no competing interests.

Editorial Board

Allgemein- und Viszeralchirurgie

St Josefs-Hospital Bochum-Linden

Dusseldorf

Germany

Disclosures

GM declares that she has no competing interests.

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