Last reviewed: November 2017
Last updated: November  2017

Summary

Definition

History and exam

Key diagnostic factors

  • dentures with palatal erythema
  • oral candidiasis

Other diagnostic factors

  • pruritus
  • painful red fissures
  • eczematous dermatitis of lower face
  • specific medications
  • hx of inflammatory bowel disease
  • hx of acid reflux
  • hx of total parenteral nutrition
  • hx of eating disorders
  • alopecia
  • diarrhea/constipation
  • bloody stool
  • aphthous ulcers
  • pale, depapillated atrophic tongue
  • red, glossy, depapillated tongue
  • red atrophic tongue
  • reddish-purple depapillated tongue
  • smooth, shiny red lips
  • dental caries
  • palatal erosions

Risk factors

  • age >75 years
  • male gender
  • dentures
  • immune deficiency
  • Down syndrome
  • xerostomia
  • chronic inflammatory skin disease
  • diabetes mellitus
  • Crohn disease

Diagnostic investigations

Investigations to consider

  • fungal culture
  • bacterial culture
  • CBC
  • serum iron panel
  • serum vitamin B12
  • serum folate
  • serum zinc
  • fasting plasma glucose
  • HbA1c
  • HIV test
  • biopsy
  • patch testing
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Professor and Vice Chair

Department of Family and Community Medicine

University of Kentucky College of Medicine

Lexington

KY

Disclosures

WCG declares that she has no competing interests.

Dr Wanda C. Gonsalves would like to gratefully acknowledge Dr Alison Bruce and Dr Kelly R. Tierney, previous contributors to this monograph. AB and KRT declare that they have no competing interests.

Peer reviewers VIEW ALL

Resident

Department of Dermatology

Wake Forest University School of Medicine

Winston-Salem

NC

Disclosures

ADL declares that he has no competing interests.

Assistant Professor of Medicine

Associate Residency Program Director

University of Chicago

Chicago

IL

Disclosures

AS declares that she has no competing interests.

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