Last reviewed: November 2017
Last updated: April  2017

Summary

Definition

History and exam

Key diagnostic factors

  • hx of environmental exposure
  • necrotic skin lesions
  • edema
  • oropharyngeal ulceration
  • painless lesions
  • influenza-like illness
  • respiratory symptoms

Other diagnostic factors

  • lymphadenopathy
  • fever
  • hypotension
  • acute abdominal pain

Risk factors

  • environmental exposure
  • occupational exposure
  • biologic terrorism
  • undercooked meat ingestion
  • heroin use

Diagnostic investigations

1st investigations to order

  • wound Gram stain and culture
  • WBC count
  • blood Gram stain and culture
  • CXR
Full details

Investigations to consider

  • CT scan
  • punch biopsy
  • pleural fluid Gram stain and culture
  • peritoneal fluid Gram stain and culture
  • lumbar puncture
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Instructor

Division of Infectious Diseases

Northwestern Feinberg School of Medicine

Chicago

IL

Disclosures

DB declares that he has no competing interests.

Infectious Diseases Fellow

Northwestern Feinberg School of Medicine

Chicago

IL

Disclosures

BW declares that he has no competing interests.

Dr Daniel Boyle and Dr Brian Wolf would like to gratefully acknowledge Dr Teresa Zembower and Dr Pavani Reddy, previous contributors to this monograph. TZ and PR declare that they have no competing interests.

Peer reviewers VIEW ALL

Regional Chairman

Residency Program Director

Associate Professor

Family and Community Medicine

Texas Tech University Health Sciences Center at the Permian Basin

Odessa

TX

Disclosures

TB declares that he has no competing interests.

Professor of Internal Medicine

Director: Unit Clinical Immunology and Allergy

Department of Clinical and Molecular Medicine

Sapienza University of Rome, S. Andrea University Hospital

Rome

Italy

Disclosures

RD declares that he has no competing interests.

Infectious Disease Specialist

Alabama Infectious Diseases Center

Huntsville

AL

Disclosures

AH declares that he has no competing interests.

Head of Novel & Dangerous Pathogens

Novel and Dangerous Pathogens

HPA Centre for Emergency Preparedness and Response

Salisbury

UK

Disclosures

TB declares that he has no competing interests.

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