Last reviewed: November 2017
Last updated: November  2017

Summary

Definition

History and exam

Key diagnostic factors

  • fever
  • dysuria (in women)
  • lymphadenopathy
  • genital ulcer
  • oral ulcer

Other diagnostic factors

  • tingling sensation
  • headache/aseptic meningitis

Risk factors

  • HIV infection (risk factor for clinical disease)
  • immunosuppressive medications (risk factor for clinical disease)
  • female sex (risk factor for seropositivity)
  • black race (risk factor for seropositivity)
  • increasing age (risk factor for seropositivity)
  • high-risk sexual behavior (risk factor for seropositivity)
  • lack of condom use (risk factor for seropositivity)

Diagnostic investigations

1st investigations to order

  • viral culture
  • HSV PCR
  • type-specific serologic IgG assay
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Assistant Professor

Division of Allergy & Infectious Diseases

Department of Medicine

University of Washington

Seattle

WA

Disclosures

CJ reports funding from AiCuris; grants from Agenus, Gilead, Genocea, Sanofi, and Vical to conduct clinical research studies; and royalties from Up To Date.

Professor

Departments of Medicine and Epidemiology

University of Washington Virology Research Clinic

Seattle

WA

Disclosures

AW reports grants from Agenus, Gilead, Genocea, Sanofi, and Vical to conduct clinical research studies. AW receives royalties from Up To Date. AW is an NIH grant recipient (NIH AI30731 and AI071113) and a consultant for Aicuris, Eisai, and Amgen.

Peer reviewers VIEW ALL

Associate Professor

Department of Surgical, Oncological and Oral Sciences

School of Dentistry

University of Palermo

Palermo

Italy

Disclosures

GP declares that he has no competing interests.

Professor of Medicine

University of North Carolina at Chapel Hill

Chapel Hill

NC

Disclosures

PL declares that he has no competing interests.

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