Results from interstitial pressure increases in closed osseofascial compartments.
Can be caused by fracture, compartment hemorrhage, direct soft-tissue injury, or direct muscular injury.
High index of suspicion and early recognition are crucial.
Intracompartmental pressures >30 to 40 mmHg or within 10 to 30 mmHg of diastolic BP are associated with significant muscle damage.
Palpable pulses distal to the involved compartment do not rule out compartment syndrome.
Prompt decompression by fasciotomy is mandatory to prevent muscle ischemia and rhabdomyolysis.
Compartment syndrome is a pathologic condition characterized by elevated interstitial pressure in a closed osseofascial compartment that results in microvascular compromise (restriction of capillary blood flow).  The compartments most commonly involved are those with relatively noncompliant osseous or fascial structures, such as the anterior and deep posterior compartments of the leg and the volar compartment of the forearm. Significant muscle damage can occur with compartment pressures >30 to 40 mmHg or within 10 to 30 mmHg of diastolic BP.  
Critical Care Surgeon
MAS declares that she has no competing interests.
Department of Plastic Surgery
The University of Texas MD Anderson Cancer Center
VJH declares that he has no competing interests.
Emeritus Professor of Orthopaedic and Accident Surgery
University of Liverpool
British Journal of Bone and Joint Surgery
LK declares that he has no competing interests.
Associate Program Director
Atlanta Medical Center
Department of General Surgery
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