Last reviewed: November 2017
Last updated: February  2017

Summary

Definition

History and exam

Key diagnostic factors

  • dyspnea
  • cough
  • crackles

Other diagnostic factors

  • weight loss, fatigue, and malaise
  • clubbing

Risk factors

  • advanced age
  • male gender
  • FHx
  • cigarette smoking
  • organic and inorganic dust exposure
  • gastroesophageal reflux
  • infection
  • diabetes

Diagnostic investigations

1st investigations to order

  • CXR
  • high-resolution CT (HRCT)
Full details

Investigations to consider

  • PFTs
  • ANAs
  • rheumatoid factor
  • surgical lung biopsy
  • bronchoalveolar lavage (BAL)
  • transbronchial biopsy
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Assistant Professor of Clinical Medicine

Pulmonary, Allergy, and Critical Care Division

Perelman School of Medicine

University of Pennsylvania

Philadelphia

PA

Disclosures

JDF declares that he has no competing interests.

Associate Professor of Clinical Medicine

Pulmonary, Allergy, and Critical Care Division

Perelman School of Medicine

University of Pennsylvania

Philadelphia

PA

Disclosures

MEK has received research support for serving as a clinical trial site principal investigator from Gilead, MedImmune, Genentech, and Sanofi.

Dr Judd David Flesch and Dr Mary Elizabeth Kreider would like to gratefully acknowledge Dr Gregory Tino and Dr Jeffrey C. Munson, previous contributors to this topic. GT has served as a consultant for InterMune. GT has served as a principal investigator for clinical trials in idiopathic pulmonary fibrosis. JCM declares that he has no competing interests.

Peer reviewers VIEW ALL

Medical Director

Lung Transplant & Advanced Lung Disease Program

Inova Fairfax Hospital

Falls Church

VA

Disclosures

SN is an author of a reference cited in this monograph.

Professor of Respiratory Medicine

Interstitial Lung Disease Unit

Royal Brompton Hospital

London

UK

Disclosures

AW declares that he has no competing interests.

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