Last reviewed: November 2017
Last updated: November  2017

Summary

Definition

History and exam

Key diagnostic factors

  • features of Marfan/Ehlers-Danlos syndromes
  • acute severe chest pain
  • interscapular pain
  • syncope
  • left/right BP differential
  • pulse differential/deficit
  • diastolic murmur
  • hypotension

Other diagnostic factors

  • hypertension
  • dyspnea
  • altered mental status
  • paraplegia
  • hemiparesis/paresthesia
  • abdominal pain
  • limb pain/pallor
  • left-sided decreased breath sounds/dullness

Risk factors

  • HTN
  • atherosclerotic aneurysmal disease
  • Marfan syndrome
  • Ehlers-Danlos syndrome
  • bicuspid aortic valve
  • annuloaortic ectasia
  • coarctation
  • smoking
  • FHx of aortic aneurysm or dissection
  • older age
  • giant cell arteritis
  • overlap connective-tissue disorders
  • surgical/catheter manipulation
  • cocaine/amphetamine use
  • heavy lifting
  • pregnancy

Diagnostic investigations

1st investigations to order

  • ECG
  • CXR
  • cardiac enzymes
  • CT scan
  • renal function tests
  • CBC
  • type and cross
Full details

Investigations to consider

  • D-dimer
  • transthoracic echocardiography (TTE)
  • transesophageal echocardiography
  • MRI
  • intravascular ultrasound
  • smooth muscle myosin heavy chain protein
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Professor and Chairman

Department of Cardiothoracic and Vascular Surgery

The University of Texas Medical School at Houston

Houston

TX

Disclosures

HJS declares that he has no competing interests.

Professor Hazim J. Safi would like to gratefully acknowledge Dr Jeffrey Wu and Dr Eric E. Roselli, previous contributors to this monograph. JW and EER declare that they have no competing interests.

Peer reviewers VIEW ALL

Associate Professor of Surgery

Acting Chief

Division of Vascular and Endovascular Surgery

Montefiore Medical Center and the Albert Einstein College of Medicine

Bronx

NY

Disclosures

EL declares that he has no competing interests.

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