Gastrin-producing neuroendocrine tumor that causes gastric acid hypersecretion and peptic ulcer disease.
Can be sporadic or associated with multiple endocrine neoplasia syndrome type 1.
Common presentation includes refractory peptic ulcer disease, abdominal pain, diarrhea, and gastroesophageal disease.
The main goal of treatment is control of gastric hypersecretion with proton-pump inhibitors.
The most common cause of morbidity and mortality is metastatic gastrinoma.
Zollinger-Ellison syndrome (ZES) is a condition caused by a gastrin-secreting tumor that causes hypersecretion of gastric acid leading to ulcer disease. It most commonly presents with abdominal pain (70% to 100%), diarrhea (37% to 73%), and gastroesophageal reflux disease (GERD) (44%). Less common presentations include weight loss, GI bleeding, nausea, and vomiting.  
Professor of Medicine
Division of Gastroenterology, Hepatology, and Parenteral Nutrition
David Geffen School of Medicine at University of California
VA Greater Los Angeles Healthcare System
Department of Veterans Affairs
JRP is an author of a number of references cited in this monograph.
Fellow in Gastroenterology
Division of Digestive Diseases
DG declares that he has no competing interests.
Dr Joseph R. Pisegna and Dr Deepinder Goyal would like to gratefully acknowledge Dr David Oh and Dr Hank Wang, the previous contributors to this monograph. DO and HW declare that they have no competing interests.
Associate Professor of Medicine Division
Gastroenterology, Hepatology and Nutrition
University of Florida
PD declares that he has no competing interests.
Newcastle-Upon-Tyne Hospitals Trust
PP declares that he has no competing interests.
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