Last reviewed: November 2017
Last updated: April  2017

Summary

Definition

History and exam

Key diagnostic factors

  • upper and lower respiratory tract involvement
  • renal involvement
  • constitutional features

Other diagnostic factors

  • ocular manifestations
  • cutaneous manifestations
  • musculoskeletal manifestations
  • neurologic manifestations
  • signs or symptoms of thromboembolism
  • white ethnicity
  • gastrointestinal involvement
  • cardiac involvement
  • breast mass
  • lower GU tract involvement
  • endocrine involvement
  • isolated mass lesions/focal granuloma

Risk factors

  • genetic predisposition
  • infection
  • environmental exposures

Diagnostic investigations

1st investigations to order

  • urinalysis and microscopy
  • CT chest
  • antineutrophil cytoplasmic antibody (ANCA)
  • CBC and differential
  • serum creatinine
  • erythrocyte sedimentation rate (ESR)
Full details

Investigations to consider

  • tissue biopsy
  • pulmonary function testing
  • bronchoscopy
  • electromyography/nerve conduction studies
  • upper airway endoscopy
  • CT sinuses
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Consultant Rheumatologist

Department of Rheumatology

St Vincent's University Hospital

Dublin

Ireland

Disclosures

EM declares that he has participated in local advisory boards for Pfizer, Roche, BMS, MSD, and Novartis. He has received conference travel/accommodation expenses from Pfizer, Roche, Abbvie, and MSD. The organisation he works for has an unrestricted educational grant from Roche to support regional educational meetings.

Peer reviewers VIEW ALL

Assistant Professor of Medicine

Rheumatology Division

University of Utah School of Medicine

Salt Lake City

UT

Disclosures

CLK declares that he has no competing interests.

Professor of Clinical Rheumatology

Musculoskeletal Research Group

Institute of Cellular Medicine

Newcastle University

The Medical School

Newcastle upon Tyne

UK

Disclosures

JMVL declares that he has no competing interests.

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