Last reviewed: November 2017
Last updated: November  2017

Summary

Definition

History and exam

Key diagnostic factors

  • shortness of breath
  • LUQ discomfort or fullness
  • epistaxis
  • arthralgia
  • sternal tenderness
  • splenomegaly

Other diagnostic factors

  • weight loss
  • excessive sweating
  • fever
  • pallor
  • bruising
  • retinal hemorrhages

Risk factors

  • ionizing radiation exposure
  • middle age
  • male gender

Diagnostic investigations

1st investigations to order

  • CBC
  • complete metabolic profile
  • peripheral blood smear
  • bone marrow biopsy
  • cytogenetics
  • quantitative reverse transcription PCR (qRT-PCR) including breakpoint analysis
  • fluorescent in situ hybridization (FISH)
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Honorary Consultant in Haematology

The Christie NHS Foundation Trust

Manchester

UK

Disclosures

TS has received travel support and speaker expenses from Novartis, and has served as a consultant to Novartis for development of drugs for indications other than CML.

Dr Tim Somervaille would like to gratefully acknowledge Dr Han Myint and Dr Robert Chen, the previous contributors to this monograph. HM sits on the advisory board of Novartis and Bristol-Myers Squibb, and also does speaking engagements on their behalf. RC declares that he has no competing interests.

Peer reviewers VIEW ALL

Chief Fellow

Section of Hematology and Oncology

Department of Internal Medicine

Wake Forest University Baptist Medical Center

Winston-Salem

NC

Disclosures

RC declares that she has no competing interests.

Professor of Haematology

Royal Liverpool University Hospital

Liverpool

UK

Disclosures

None disclosed.

Use of this content is subject to our disclaimer