Common malignancy, usually an adenocarcinoma.
Obesity is associated with an increased incidence and poorer outcome.
Patients typically present with postmenopausal vaginal bleeding and often have surgically curable disease.
Diagnosis is confirmed by biopsy or D&C. Staging and histology is confirmed at surgery.
The most important prognostic information relates to stage, histologic subtype, tumor grade, patient age, and presence of lymphovascular space invasion.
Adjuvant vaginal brachytherapy or pelvic external beam radiation therapy reduce local failure rates and improve progression-free survival without an impact on overall survival in stages I and II disease.
Chemotherapy is an increasingly important component of care for patients with stages III and IV and recurrent endometrial cancer.
An epithelial malignancy of the uterine corpus mucosa, usually an adenocarcinoma.
Division of Gynecologic Oncology
Department of Obstetrics, Gynecology, and Reproductive Sciences
Magee-Womens Hospital of UPMC
University of Pittsburgh School of Medicine
ABO declares that he has no competing interests.
Medical Gynecologic Oncology
Division of Hematology Oncology
Massachusetts General Hospital
RTP declares that he is on the scientific advisory boards of: Genentech, Inc., AstraZeneca, Endocyte, Inc., Eisai Inc., Vascular Biogenics Ltd, Baxalta Oncology, AbbVie, and Clovis Oncology. RTP receives research funding from: Genentech, Inc., ImClone Systems, Inc., Endocyte, Inc., AstraZeneca., Eisai Inc., Amgen Inc., and Vascular Biogenics Ltd. RTP was an expert witness for Aventis Pharma S.A. Vs. Apotex Inc in 2009. RTP has received royalties from: BMJ, Blackwell Publishing Medicine at a glance, and UpToDate Advance Medical: Second Medical Opinion.
Department of Radiation Oncology
Brigham and Women’s Hospital/Dana-Farber Cancer Institute
LJL declares that she has no competing interests.
Dr Alexander B. Olawaiye, Dr Richard T. Penson, and Dr Larissa J. Lee would like to gratefully acknowledge Dr Neil S. Horowitz and Dr Anthony H. Russell, previous contributors to this monograph. NSH and AHR declare that they have no competing interests.
S/M Obstetrics & Gynecology (UCD)
University of Colorado Health Sciences Center
SAD declares that she has no competing interests.
Assistant Professor of Radiology
Memorial Sloan-Kettering Cancer Center
SM declares that she has no competing interests.
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