Last reviewed: November 2017
Last updated: October  2016

Summary

Definition

History and exam

Other diagnostic factors

  • age 20 to 70 years
  • nocturia, polyuria
  • lethargy
  • mood disturbance (irritability, anxiety, depression)
  • difficulty concentrating
  • paresthesias, muscle cramps
  • muscle weakness
  • palpitations

Risk factors

  • FHx of PA
  • FHx of early onset of HTN and/or stroke

Diagnostic investigations

1st investigations to order

  • plasma potassium
  • aldosterone/renin ratio
Full details

Investigations to consider

  • fludrocortisone suppression test
  • saline infusion testing
  • oral salt loading
  • genetic testing for hybrid gene
  • adrenal CT
  • adrenal venous sampling
  • adrenal MRI
  • adrenal selenocholesterol scanning
  • posture stimulation testing
  • angiotensin II infusion testing
  • 24-hour urinary hybrid steroids (18-hydroxy- and 18-oxo-cortisol)
  • dexamethasone suppression testing
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Michael Stowasser

Professor

Endocrine Hypertension Research Centre

University of Queensland School of Medicine

Greenslopes and Princess Alexandra Hospitals

Brisbane

Queensland

Australia

Disclosures

MS is an author of references cited in this monograph.

Richard D. Gordon

Professor

Endocrine Hypertension Research Centre

University of Queensland School of Medicine

Greenslopes and Princess Alexandra Hospitals

Brisbane

Queensland

Australia

Disclosures

RDG is an author of references cited in this monograph.

Peer reviewers VIEW ALL

Department of Medicine and Experimental Oncology

Division of Medicine and Hypertension

San Giovanni Battista Hospital

Torino

Italy

Disclosures

PM declares that he has no competing interests.

Clinical Professor

Department of Family Medicine

University of North Carolina

Chapel Hill

Assistant Program Director

MAHEC Rural Family Medicine Residency

Hendersonville

NC

Disclosures

WM declares that he has no competing interests.

Use of this content is subject to our disclaimer