Last reviewed: November 2017
Last updated: November  2017

Summary

Definition

History and exam

Key diagnostic factors

  • rash
  • mucosal involvement
  • blisters
  • Nikolsky sign

Risk factors

  • anticonvulsant medications
  • recent infection
  • recent antibiotic use
  • other medications
  • SLE
  • AIDS
  • radiation therapy
  • bone marrow transplantation
  • HLA and genetic predisposition
  • smallpox vaccination

Diagnostic investigations

1st investigations to order

  • skin biopsy
  • blood cultures
  • CBC
  • LFTs
  • arterial blood gases and saturation of oxygen
Full details

Investigations to consider

  • BUN
  • serum electrolytes
  • serum creatinine
  • direct immunofluorescence
Full details

Treatment algorithm

ACUTE

Contributors

Authors VIEW ALL

Assistant Professor

Department of Surgery

Rush University Medical Center

Chicago

IL

Disclosures

AK-V has received compensation for reviewing manuscripts for Rubriq from Research Square on a variety of topics, including erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis. She is also a manuscript reviewer for several journals, without renumeration.

Peer reviewers VIEW ALL

Director Burn Unit

Department of Surgery

University of Iowa Hospitals

Iowa City

IA

Disclosures

BAL declares that she has no competing interests.

Assistant Chief of Burns

Shriners Hospital

UC Davis

Sacramento

CA

Disclosures

TP declares that she has no competing interests.

Consultant Dermatologist

Department of Dermatology

West Suffolk Hospital

Bury St. Edmunds

UK

Disclosures

VG declares that he has no competing interests.

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