Last reviewed: November 2017
Last updated: November  2017

Summary

Definition

History and exam

Key diagnostic factors

  • recent crush injury
  • prolonged immobilization
  • presence of other risk factors
  • muscular pain

Other diagnostic factors

  • general malaise
  • dark urine
  • muscular swelling
  • muscular tenderness
  • diminished peripheral pulse
  • prolonged capillary refill

Risk factors

  • trauma
  • alcohol
  • cocaine
  • amphetamine
  • phencyclidine
  • narcotics
  • diuretics
  • statins
  • salicylate toxicity
  • toxins
  • envenomation
  • inflammatory disorders
  • muscle hypoxia
  • genetic disorders
  • metabolic disorders
  • infection
  • increased body temperature

Diagnostic investigations

1st investigations to order

  • serum CK level
  • serum electrolytes
  • renal function
  • CBC
  • coagulation studies
  • urine dipstick
  • urine microscopy
  • myoglobin levels
Full details

Treatment algorithm

Contributors

Authors VIEW ALL

Associate Professor of Surgery

Associate Director of Trauma Services

Chief of Acute Care Surgery

Duke University Medical Center

Durham

NC

Disclosures

MS is an author of references cited in this topic.

Assistant Professor of Surgery

Surgery/Trauma and Critical Care

Duke University Medical Center

Durham

NC

Disclosures

CS declares that she has no competing interests.

Dr Mark Shapiro and Dr Courtney Sommer would like to gratefully acknowledge Dr Robert D. Mathis, a previous contributor to this topic. RDM declares that he has no competing interests.

Peer reviewers VIEW ALL

Chief

Division of Pulmonary and Critical Care Medicine

University of California, Davis

Sacramento

CA

Disclosures

TA declares that he has no competing interests.

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